Quality of life and mental health of patients with vascular malformations in a single specialist center in the United Kingdom

Pang, Calver; Gibson, Michael D.; Nisbet, R; Evans, Nicholas; Khalifa, Mohamed; Papadopoulou, Anthie; Tsui, Janice; Hamilton, George; Brookes, Jocelyn; Lim, Chung Sim

doi:10.1016/j.jvsv.2021.03.019

Cited by 10 publications

(12 citation statements)

References 31 publications

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“…Congenital vascular malformations (CVM) are lesions derived from aberrant embryonic development of vascular channels and feature dysplastic abnormally formed vessels that consists of arteries, veins, capillaries or lymphatics or a combination of these vessels. 1,2 Patient with CVMs may suffer from chronic debilitating symptoms including pain, swelling, disfigurement, ulceration, bleeding, thromboembolism, infection and end-organ ischaemia and failure. As a result, patients with CVMs have been shown to report significantly poorer quality of life (QoL) compared with the general population including in our patient cohort.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, patients with CVMs have been shown to report significantly poorer quality of life (QoL) compared with the general population including in our patient cohort. 1 CVMs are described and classified by the vessels involved and their flow characteristics. Haemodynamically, these lesions may demonstrate slow/low or fast/high fluid flow.…”

Section: Introductionmentioning

confidence: 99%

“…The understanding of molecular biology in vascular malformations has evolved over the years and has enabled a better understanding of the pathogenesis and molecular mechanisms underlying vascular malformations. 2 Venous malformations (VM) are the most frequent low-flow vascular malformations with an estimated incidence of around 1 in 10 000 5 whereas arteriovenous malformations (AVM) affect approximately 1 in 100 000. 6 VMs are typically managed conservatively with compression devices to prevent thrombosis and pain.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, patients with CVMs have been shown to report significantly poorer quality of life (QoL) compared with the general population including in our patient cohort. 1…”

Section: Introductionmentioning

confidence: 99%

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Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre

et al. 2022

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Objective The study aimed to evaluate the early follow-up quality of life (QoL), pain and mental health of patients with congenital vascular malformation (CVM) from a variety of treatment options. Methods All patients with CVM who received care and had follow-up between February 1st 2018 and January 31st 2020 were included. The health-related QoL, pain, and mental health were assessed with RAND Health Care 36-Item Short Form Survey (SF-36), visual analogue score for pain (VAS-P) and Hospital Anxiety and Depression Scale (HADS). Paired t-test was used for all analyses. p < .05 were considered significant. Results In total, 110 patients with a mean age of 36.9 years were included in this study. In all patients following care, significant improvement was found in the bodily pain domain of SF-36 and VAS-P (both p = .01). This was largely driven by high-flow vascular malformation patients who responded better to embolo-sclerotherapy, which revealed significant improvement in the bodily pain domain of SF-36 ( p = .002) and VAS-P ( p = .02). Patients who received supportive treatment only reported significant improvement in mental health ( p = .004) and social functioning ( p = .03) domains of SF-36. Meanwhile, patients treated with embolo-sclerotherapy reported significant improvement only in VAS-P ( p = .02). Conclusions This study concluded that the effects of care on early follow-up QoL, pain and mental health of patients with CVM were heterogenous. Future research should therefore, include larger sample size and longer term follow-up to understand the various factors that affect the QoL and mental health of these patients, as well as the holistic approaches to manage them.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…As a result, patients with CVMs have been shown to report significantly poorer quality of life (QoL) compared with the general population including in our patient cohort. 1…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre

et al. 2022

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“… 1 Besides physical symptoms, AVMs is also a debilitating chronic condition that affects all age groups mentally and socially including their quality of life; therefore, improvement in their management will have significant benefits to the socio-economics and healthcare costs despite being rare. 3 Diagnosis of AVM is based on clinical history and physical examination, supported by Doppler ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) scans and intra-arterial digital subtraction angiography (DSA). 4 DSA is a fluoroscopic technique used for visualising blood vessels in which radiopaque structures, such as bones, are “subtracted” digitally from the image, thus allowing for an accurate visualisation of the blood vessels.…”

Section: Introductionmentioning

confidence: 99%

A Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations

Franzetti

Bonfanti

Tanade

et al. 2021

Cardiovasc Eng Tech

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Purpose Peripheral arteriovenous malformations (pAVMs) are congenital lesions characterised by abnormal high-flow, low-resistance vascular connections—the so-called nidus—between arteries and veins. The mainstay treatment typically involves the embolisation of the nidus, however the complexity of pAVMs often leads to uncertain outcomes. This study aims at developing a simple, yet effective computational framework to aid the clinical decision making around the treatment of pAVMs using routinely acquired clinical data. Methods A computational model was developed to simulate the pre-, intra-, and post-intervention haemodynamics of a patient-specific pAVM. A porous medium of varying permeability was employed to simulate the sclerosant effect on the nidus haemodynamics. Results were compared against clinical data (digital subtraction angiography, DSA, images) and experimental flow-visualization results in a 3D-printed phantom of the same pAVM. Results The computational model allowed the simulation of the pAVM haemodynamics and the sclerotherapy-induced changes at different interventional stages. The predicted inlet flow rates closely matched the DSA-derived data, although the post-intervention one was overestimated, probably due to vascular system adaptations not accounted for numerically. The nidus embolization was successfully captured by varying the nidus permeability and increasing its hydraulic resistance from 0.330 to 3970 mmHg s ml−1. The nidus flow rate decreased from 71% of the inlet flow rate pre-intervention to 1%: the flow completely bypassed the nidus post-intervention confirming the success of the procedure. Conclusion The study demonstrates that the haemodynamic effects of the embolisation procedure can be simulated from routinely acquired clinical data via a porous medium with varying permeability as evidenced by the good qualitative agreement between numerical predictions and both in vivo and in vitro data. It provides a fundamental building block towards a computational treatment-planning framework for AVM embolisation.

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Efficacy and safety of foam sclerotherapy with sodium tetradecyl sulfate as preferred sclerosant of venous malformations based on experience from a single specialist center

Arasakumar¹,

Pang²,

Evans³

et al. 2023

Journal of Vascular Surgery: Venous and Lymphatic Disorders

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Quality of life and mental health of patients with vascular malformations in a single specialist center in the United Kingdom

Cited by 10 publications

References 31 publications

Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre

Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre

A Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations

Efficacy and safety of foam sclerotherapy with sodium tetradecyl sulfate as preferred sclerosant of venous malformations based on experience from a single specialist center

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