Quality of Life in Infertile Women with Polycystic Ovary Syndrome: a Comparative Study

Naumova, Iuliia; Castelo-Branco, Camil; Kasterina, Iuliia; Casals, Gemma

doi:10.1007/s43032-020-00394-1

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…Moreover, PCOS may increase the risk of depressive, anxiety, and sleep disorders and reduce quality of life (QoL), particularly in patients with hirsutism, weight gain and acne ( 63 ). PCOS patients with infertility present worse QoL because of psychological and emotional distress ( 64 ).…”

Section: Bat As a Novel Management Strategy For Polycystic Ovary Synd...mentioning

confidence: 99%

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

Zhang

et al. 2022

Front. Endocrinol.

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Brown adipose tissue (BAT), a unique tissue, plays a key role in metabolism and energy expenditure through adaptive nonshivering thermogenesis. It has recently become a therapeutic target in the treatment of obesity and metabolic diseases. The thermogenic effect of BAT occurs through uncoupling protein-1 by uncoupling adenosine triphosphate (ATP) synthesis from energy substrate oxidation. The review discusses the recent developments and progress associated with the biology, function, and activation of BAT, with a focus on its therapeutic potential for the treatment of polycystic ovary syndrome (PCOS). The endocrine activity of brown adipocytes affects the energy balance and homeostasis of glucose and lipids, thereby affecting the association of BAT activity and the metabolic profile. PCOS is a complex reproductive and metabolic disorder of reproductive-age women. Functional abnormalities of adipose tissue (AT) have been reported in patients with PCOS. Numerous studies have shown that BAT could regulate the features of PCOS and that increases in BAT mass or activity were effective in the treatment of PCOS through approaches including cold stimulation, BAT transplantation and compound activation in various animal models. Therefore, BAT may be used as a novel management strategy for the patients with PCOS to improve women’s health clinically. It is highly important to identify key brown adipokines for the discovery and development of novel candidates to establish an efficacious therapeutic strategy for patients with PCOS in the future.

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Section: Bat As a Novel Management Strategy For Polycystic Ovary Synd...mentioning

confidence: 99%

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

Zhang

et al. 2022

Front. Endocrinol.

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“…5 The clinical features of PCOS, particularly hirsutism and weight gain, can significantly impact quality of life (QOL). 6 The subfertility experience reflects negatively on QOL due to resultant psychological and emotional distress. Nurse practitioners (NPs) who provide women's healthcare must be aware of the long-term health risks associated with PCOS and prepared to provide appropriate assessment, counseling, and management options.…”

Section: Polycystic Ovary Syndrome: Diagnosis and Managementmentioning

confidence: 99%

“…A QOL screening tool specific to PCOS, the Polycystic Ovary Health Related Quality of Life Questionnaire (PCOSQ) or the modified PCOSQ, may be used to help determine patient concerns and priorities. 3,6,8,16 The modified PCOSQ includes an acne domain. Screening for anxiety and depression is recommended in both adolescent and adult women at diagnosis.…”

Section: Managementmentioning

confidence: 99%

Polycystic ovary syndrome: Diagnosis and management

Platt¹

2022

WHC

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“…Notably, in 2017, Martin et al conducted semi-structured interviews and reported that pain- and discomfort-related symptoms were the most common complaints among patients with PCOS, accounting for 27.6% of the complaints made by all interviewed patients [ 15 ]. Further, HRQoL-based studies and systematic reviews are increasingly indicating that bodily pain expression is significantly elevated in patients with PCOS [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Although the symptoms of PCOS related to hyperandrogenism, metabolism, and reproductive function are heterogeneous and well-established, the symptoms involving bodily pain are still a topic of debate.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors

Chang

et al. 2022

Biomedicines

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Polycystic ovary syndrome (PCOS) is the most common reproductive disease affecting the hormone and metabolic status of women. Its associated symptoms are diverse among the patients, including hyperandrogenism, insulin resistance, anovulation, infertility, obesity, hirsutism, acne, and more. In addition, PCOS can potentially increase the risk of dysmenorrhea, endometriosis, endometrioma, and irritable bowel syndrome, which are highly related to pelvic pain and sexual difficulty. However, little known is whether PCOS exacerbates other chronic bodily pain or contributes to hyperalgesia. Health-related quality of Life (HRQoL) reflects the life satisfaction and quality derived by an individual from mental, physical, emotional, and social activities under specific conditions. In this study, we reviewed pain perception from HRQoL of PCOS patients (SF-36). The review data evidently indicated that pain perception is significantly more prevalent in patients with PCOS than in healthy controls, and obesity and infertile status could be the rationales associated with pain development. Nevertheless, underlying causes remain undetermined due to the limited information from SF-36. Furthermore, we reviewed pathophysiologic factors to pain development or exacerbation, such as the deregulation of inflammation levels, adipokines, and insulin resistance. Although current evidence of pain perception and pathophysiologic risk factors are solid in PCOS, patients’ pain perception is often ignored in clinical settings. Clinicians should note the perception and treatment of pain in PCOS patients. The correlation or causality between pain and PCOS warrants further clinical examination and basic studies, thereby providing new insights into this topic in the context of clinical diagnosis and health care.

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Quality of Life in Infertile Women with Polycystic Ovary Syndrome: a Comparative Study

Cited by 16 publications

References 31 publications

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

Polycystic ovary syndrome: Diagnosis and management

Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors

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