Quality of life in patients with acromegaly receiving lanreotide autogel: a real-world observational study

Bolanowski, Marek; Hubalewska‐Dydejczyk, Alicja; Kos–Kudła, Beata; Ruchała, Marek; Witek, Przemysław; Zgliczyński, Wojciech; Houchard, Aude; Bartmańska, Marta

doi:10.5603/ep.a2021.0075

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Noteworthy, controversial results have been reported, since the poor quality of life seen at diagnosis of acromegaly has been demonstrated either to persist despite long-term remission regardless of the treatment used to achieve biochemical control (109)(110)(111)(112)(113), or to improve after GH and IGF-I normalization (114)(115)(116). Lower AcroQol scores have been reported in patients with long disease duration (109,112), multiple comorbidities (117) and in women (118).…”

Section: Discussionmentioning

confidence: 99%

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Pivonello

Auriemma

Veneri

et al. 2022

European Journal of Endocrinology

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Objective: Acromegaly is associated with somatic disfigurements which impair self-perception of well-being and quality of life. Nowadays limited data are available on the interplay between hormonal excess and psychological discomfort. The study aimed at investigating the psychological profile, sleep quality, sexual function, cognitive functions, and quality of life in acromegaly. Methods: in 223 acromegaly patients from five referral centres global psychological profile, sleep quality, sexual function, cognitive function, and quality of life were investigated. Results: depression was found in 30% of patients, and anxiety in two-thirds, together with severe discomfort in body image mainly in women. Obstructive sleep apnea syndrome (OSAS)risk and sleep disorders were found in >50% of patients, and daily sleepiness in 20%. Sexual dysfunction was reported in most patients, with the most severe impairment in women. Cognitive functions were compromised in 10% of cases. Disease duration, patient age and gender were the main determinants of such psychological effects. Depression (p=0.047), somatic affective mood lowering (p=0.021), state (p<0.001) and trait (p=0.013) anxiety, and body image distortion at Body Uneasiness Test (BUT) A (p<0.001) and B (p=0.006) were significantly worsened in patients <45 years, and slightly worsen in those diagnosed <2 years before. International Index for Erectile Function (IIEF)-15 (p<0.001) and Female Sexual Function Index (FSFI) (p<0.001) scores were significantly worsened in patients >64 years and slightly worsened in those diagnosed >10 years before, particularly in presence of cardiometabolic and respiratory complications. Cognitive symptoms were slightly worsened in older patients and in those with long disease. Conclusions: Acromegaly is associated with a relevant impairment of psychological profile persisting despite remission and long-term medical treatment.

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Section: Discussionmentioning

confidence: 99%

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Pivonello

Auriemma

Veneri

et al. 2022

European Journal of Endocrinology

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“…Applying disease-specific instruments to evaluate the quality of life in a specific patient population is of significant advantage as these instruments measure aspects specific to the population in question. Previous studies indicated quality of life is impaired in patients with acromegaly [ 30 , 31 ]. However, it remains stable after administration of somatostatin analogues [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicated quality of life is impaired in patients with acromegaly [ 30 , 31 ]. However, it remains stable after administration of somatostatin analogues [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Validation of Acromegaly Quality of Life Questionnaire (AcroQoL) for the Iranian population

et al. 2022

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Background Acromegaly is a chronic disease significantly affects the physical, emotional, and health-related aspects of patients' life. This study aimed to validate the Acromegaly Quality of Life Questionnaire (AcroQoL) for the Persian-speaking population. Methods This cross-sectional study recruited 73 Iranian patients with a confirmed diagnosis of acromegaly. The content validity of the scales was evaluated by an expert panel of eight endocrinologists applying content validity index (CVI) and content validity ratio (CVR). Construct validity was assessed by using confirmatory factor analysis. Internal consistency was assessed on the basis of Cronbach’s alpha, and a goodness-of-fit (GoF) index was calculated to display whether the model fitted the data. Results CVI and CVR yielded values of 0.85 and 0.80, respectively (Acceptable CVI: > 0.78 and CVR: > 0.75). The average variances extracted (AVE) from physical and psychological dimensions were 0.520 and 0.462, respectively, exceeding the minimum criterion of 0.40. Cronbach’s alpha for physical and psychological dimensions equaled 0.868 and 0.866, respectively, indicating the adequate internal consistency of multiple items for each construct. The subscales’ R square and path coefficient were greater than the recommended threshold as 0.75 (physical dimension: 0.778, psychological dimension: 0.873), demonstrating the suitability of this criterion. Finally, the GoF value of 0.29 indicated the model's moderate fit. Conclusions The findings revealed that the Persian version of AcroQoL is of adequate validity and reliability for evaluating the quality of life of Iranian people with acromegaly.

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“…Acromegaly (AG) is a rare disease caused by excessive production of the growth hormone (GH) and insulin-like growth factor 1 (IGF1) ( 12 ). In more than 90% of cases, the disorder stems from a GH-secreting pituitary adenoma ( 13 , 14 ), and as a consequence, patients present with somatic growth, metabolic dysfunctions ( 15 , 16 ), and a decreased quality of life ( 17 ). The stimulatory effect of GH on the mammalian erythropoiesis in vitro has been widely recognized ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Iron Homeostasis and Hepcidin Concentration in Patients With Acromegaly

et al. 2022

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Hepcidin is a protein responsible for maintaining iron (Fe) homeostasis. Data regarding the role of hepcidin in the pathomechanism of Fe balance disturbances associated with acromegaly (AG) are scarce. The aim of the study was to assess the impact of alterations in complete blood count parameters, Fe homeostasis, gonadal status and GH/IGF-1 on the level of hepcidin in AG patients. The study evaluated the differences in hepcidin concentration and iron homeostasis between patients newly diagnosed with AG in comparison to healthy control subjects (CS). We prospectively enrolled 25 adult patients newly diagnosed with AG and 25 healthy volunteers who served as CS. The level of hepcidin was measured using the Hepcidin 25 (bioactive) hs ELISA, which is a highly sensitive enzyme immunoassay for the quantitative in vitro diagnostic measurement (DRG Instruments GmbH, Germany). The median of hepcidin concentration in the serum of patients with AG was significantly lower 9.8 (6.2–18.2) ng/ml as compared to CS 21.3 (14.3–34.0) ng/ml (p = 0.003). In the AG group, a statistically significant negative correlation between hepcidin and IGF-1 (rho = −0.441) was observed. Our study demonstrated a decreased hepcidin level in AG patients in comparison to CS what may have a potentially protective effect against anemia through an increased bioavailability of Fe. Additionally, GH may have a positive direct or indirect effect on erythropoiesis. Further studies on larger patient groups are necessary in order to clarify the exact role of hepcidin in the regulation of erythropoiesis in the excess of GH/IGF-1.

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Quality of life in patients with acromegaly receiving lanreotide autogel: a real-world observational study

Cited by 4 publications

References 34 publications

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Validation of Acromegaly Quality of Life Questionnaire (AcroQoL) for the Iranian population

Iron Homeostasis and Hepcidin Concentration in Patients With Acromegaly

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