Quality of life in survivors after a period of hospitalization in the intensive care unit: a systematic review

Abstract

ObjectiveTo assess the long-term, health-related quality of life of intensive care unit survivors by systematic review.MethodsThe search for, and selection and analysis of, observational studies that assessed the health-related quality of life of intensive care unit survivors in the electronic databases LILACS and MEDLINE® (accessed through PubMed) was performed using the indexed MESH terms "quality of life [MeSH Terms]" AND "critically illness [MeSH Terms]". Studies on adult patients without specific prior diseases published in English in the last 5 years were included in this systematic review. The citations were independently selected by three reviewers. Data were standardly and independently retrieved by two reviewers, and the quality of the studies was assessed using the Newcastle-Ottawa scale.ResultsIn total, 19 observational cohort and 2 case-control studies of 57,712 critically ill patients were included. The follow-up time of the studies ranged from 6 months to 6 years, and most studies had a 6-month or 1-year follow up. The health-related quality of life was assessed using two generic tools, the EuroQol and the Short Form Health Survey. The overall quality of the studies was low.ConclusionsLong-term, health-related quality of life is compromised among intensive care unit survivors compared with the corresponding general population. However, it is not significantly affected by the occurrence of sepsis, delirium, and acute kidney injury during intensive care unit admission when compared with that of critically ill patient control groups. High-quality studies are necessary to quantify the health-related quality of life among intensive care unit survivors.

Quality of Life, Depression, and Anxiety in Survivors of Critical Illness from a Greek ICU. A Prospective Observational Study

“…Both the length of ICU stay and the presence of depressive symptomatology, as measured by the CES-D, were significantly related to HRQOL. Regarding the length of ICU stay, it has not been consistently reported to be related to worse HRQOL [ 1 , 2 , 3 , 8 ]. On the contrary, most studies examining depressive symptomatology state that post-ICU depressive symptoms were associated with substantially lower HRQOL [ 24 ].…”

“…Firstly, our data did not contain information on the severity of illness, such as the Acute Physiology and Chronic Health Evaluation (APACHE II) or the Sequential Organ Failure Assessment (SOFA) scores. The inclusion of such data would have allowed us to add to the existing knowledge on the relative importance of preexisting comorbidities versus acute illness factors in relation to HRQOL [ 1 , 9 ]. Secondly, the lack of power analysis for sample size estimation and the high mortality and dropout rate in our initial population increased the risk of bias.…”

“…For these reasons, HRQOL has emerged as an important measure of outcome in ICU survivors. Numerous studies, including meta-analyses, have reported poor HRQOL in ICU survivors in the months and years following hospital discharge when compared to normal controls [ 1 , 2 , 3 ]. Factors related to worse HRQOL are age, sex, health status prior to ICU admission, length of ICU stay, the severity of illness, the presence of organ failures, the admission diagnosis, and the quality of sleep after ICU discharge [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

“…ICU, Intensive Care Unit;1 Mean ± Standard Deviation (SD);2 Absolute number (%);3 Median (Interquartile Range);4 At the time of the interview.…”

Qualidade de vida em indivíduos diabéticos em terapia renal substitutiva: revisão sistemática

“…A pontuação total pode variar de zero a nove estrelas, em que uma estrela corresponde a um ponto, sendo que, duas estrelas podem ser atribuídas na dimensão comparabilidade. Estudos entre seis e nove pontos foram considerados de alta qualidade metodológica, quatro e cinco pontos com moderada qualidade e menor que quatro pontos com baixa qualidade (Fontela et al, 2018;Ribeiro et al, 2018;Rocha et al, 2018).…”