Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity

Samara, Wasim A.; Shahlaee, Abtin; Adam, Murtaza K.; Khan, Mohammed; Chiang, Allen; Maguire, Joseph I.; Hsu, Jason; Ho, Allen C.

doi:10.1016/j.ophtha.2016.10.008

Cited by 299 publications

(296 citation statements)

References 30 publications

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“…Yet, it is noteworthy that the calculation of FAZ circularity in this study is different from Durbin’s study. Although recent OCT-A studies showed that enlarged FAZ9 11 and decreased VD9 are correlated with poorer VA in individuals with diabetes, such associations could not be replicated in our study or in Durbin et al ’s study 8. This could be explained by the large variation in the size of FAZ among individuals20 21 and measurement of VD does not take into account the continuity of perfusion area 15 16.…”

Section: Discussioncontrasting

confidence: 68%

Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

et al. 2018

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Section: Discussioncontrasting

confidence: 68%

Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

et al. 2018

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“…FAZ enlargement is related to worse vision in diabetic retinopathy and retinal vein occlusions. 26,27 Capillary density of both plexuses is correlated to visual loss in diabetic retinopathy, 28 branch retinal vein occlusion, 29,30 and idiopathic macular telangiectasia type 1 (MacTel1). 31 In addition, several investigators have shown that decreased perfusion is more frequent in the deep than superficial plexus, in central or branch vein occlusion, 32-34 diabetic retinopathy, 35 and MacTel1.…”

Section: Discussionmentioning

confidence: 99%

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Matet

Daruich

Zografos

2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT angiography (OCTA).METHODS. This was a retrospective analysis of consecutive patients with radiation maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged with fluorescein angiography, OCT, and OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area, vascular density, and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP). Nonirradiated fellow eyes served as controls. RESULTS.Ninety-three patients were included. FAZ was larger, while SCP/DCP capillary density and local fractal dimension were lower in the 35 irradiated than in the 35 fellow eyes (P < 0.0001). Microvascular alterations graded on fluorescein angiography (minimally damaged/ disrupted/disorganized) were correlated to FAZ area and SCP/DCP density on OCTA (P < 0.01). By univariate analysis, worse VA was associated to macular detachment at presentation (P ¼ 0.024), total macular irradiation (P ¼ 0.0008), higher central macular thickness (CMT) (P ¼ 0.019), higher absolute CMT variation (P < 0.0001), cystoid edema (P ¼ 0.030), ellipsoid zone disruption (P ¼ 0.002), larger FAZ (P < 0.0001), lower SCP (P ¼ 0.001) and DCP capillary density (P < 0.0001), and lower SCP (P ¼ 0.009) and DCP local fractal dimension (P < 0.0001). Two multivariate models with either capillary density or fractal dimension as covariate showed that younger age (P ¼ 0.014/0.017), ellipsoid zone disruption (P ¼ 0.034/0.019), larger FAZ (P ¼ 0.0006/0.002), and lower DCP density (P ¼ 0.008) or DCP fractal dimension (P ¼ 0.012), respectively, were associated with worse VA.CONCLUSIONS. VA of eyes with radiation maculopathy is influenced by structural and microvascular factors identified with OCTA, including FAZ area and DCP integrity.

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“…The final feature extracted was the size of the FAZ. An enlargement of the zone is usually found in patients with DR because of the loss of capillaries in the perifoveal capillary network 7. After extracting the FAZ, the distance map was calculated to represent the segmented area as a local feature (figure 3 and online supplementary figure 3).…”

Section: Methodsmentioning

confidence: 99%

Automated diabetic retinopathy detection using optical coherence tomography angiography: a pilot study

et al. 2018

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Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity

Cited by 299 publications

References 30 publications

Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Automated diabetic retinopathy detection using optical coherence tomography angiography: a pilot study

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