Quantification of skin penetration of antioxidants of varying lipophilicity

Abla, M. J.; Banga, Ajay K.

doi:10.1111/j.1468-2494.2012.00728.x

Cited by 54 publications

(40 citation statements)

References 47 publications

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“…Keratinocytes are known to build a tight layer of cells that can be used as epidermal grafts (Fig. S2g) 37 , and these cells represent a prime target for lotions and emollients based on RSV 38,39 .…”

Section: Effects On Primary Human Keratinocytesmentioning

confidence: 99%

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

Plauth

Geikowski

Cichon

et al. 2016

Preprint

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ABSTRACT:Resveratrol has gained tremendous interest owing to multiple reported healthbeneficial effects. However, the underlying key mechanism of action of resveratrol remained largely controversial. Here, we demonstrate that under physiologically relevant conditions major biological effects of resveratrol can be attributed to the generation of oxidation products such as reactive oxygen species (ROS). At low hormetic concentrations (< 50 µM), treatment with resveratrol increased cell viability in a set of representative cell models, whereas application of quenchers of ROS completely truncated these beneficial effects. Notably, application of resveratrol led to mild, Nrf2-specific cellular gene expression reprogramming. For example, in 2 primary human epidermal keratinocytes this resulted in a 1.3-fold increase of endogenous metabolites such as glutathione (GSH) and subsequently in a quantitative reduction of the cellular redox environment by 2.61 mV mmol GSH per g protein.After external application of oxidative stress by using 0.8% (v/v) ethanol, endogenous generation of ROS was consequently reduced by 24% in resveratrol pre-treated cells.In contrast to the common perception that resveratrol acts mainly as a chemical antioxidant or as a target protein-specific ligand, we propose that effects from resveratrol treatment are essentially based on oxidative triggering of cells. In relevant physiological microenvironments this effect can lead to hormetic shifting of cellular defence towards a more reductive state to improve resilience to oxidative stress in a manner that can be exactly defined by the redox-environment of the cell.

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Section: Effects On Primary Human Keratinocytesmentioning

confidence: 99%

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

Plauth

Geikowski

Cichon

et al. 2016

Preprint

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show abstract

“…Since the endogenous antioxidant concentration decreases from the outermost to the deeper layers of the skin, natural antioxidants can be applied topically to protect skin from oxidative stress induced by UV radiation, although not all antioxidants have similar affinity for different layers of the skin (Abla and Banga, 2013). In order to confirm the potential of the extracts for topical use, irritability assays with the Episkin test were performed.…”

Section: Irritability Testsmentioning

confidence: 99%

Potential of antioxidant extracts produced by aqueous processing of renewable resources for the formulation of cosmetics

Balboa

Soto

Nogueira

et al. 2014

Industrial Crops and Products

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The performance of natural extracts obtained from underutilized and residual vegetal and macroalgal biomass processed with food-grade green solvents was compared with that of commercial antioxidants. Selected extracts were obtained from two terrestrial sources: winery byproducts concentrate (WBC) and chestnut burs hydrothermally fractionated extract (CBAE), and from two underutilized seaweeds: Sargassum muticum extracts, either extracted with ethanol (SmEE) or after alginate extraction and hydrothermal fractionation (SmAE) and from Ulva lactuca processed by mild acid extraction and membrane concentration (UlAE). These extracts showed in vitro antioxidant properties comparable to commercial antioxidants and were safe for topical use based on the absence of skin-irritant effects at 0.1% on reconstructed human tissues. The stability of several cosmetic model emulsions was assessed during accelerated oxidation assays. The incorporation of natural extracts produced from renewable underutilized resources at 0.4-0.5% in an oil in water emulsion reduced lipid oxidation during storage. ABSTRACTThe performance of natural extracts obtained from underutilized and residual vegetal and macroalgal biomass processed with food-grade green solvents was compared with that of commercial antioxidants. Selected extracts were obtained from two terrestrial sources: winery byproducts concentrate (WBC) and chestnut burs hydrothermally fractionated extract (CBAE), and from two underutilized seaweeds: Sargassum muticum extracts, either extracted with ethanol (SmEE) or after alginate extraction and hydrothermal fractionation (SmAE) and from Ulva lactuca processed by mild acid extraction and membrane concentration (UlAE).These extracts showed in vitro antioxidant properties comparable to commercial antioxidants and were safe for topical use based on the absence of skin-irritant effects at 0.1% on reconstructed human tissues. The stability of several cosmetic model emulsions was assessed during accelerated oxidation assays. The incorporation of natural extracts produced from renewable underutilized resources at 0.4-0.5% in a oil-in-water emulsions reduced lipid oxidation during storage.

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“…While the skin penetration of trans-resveratrol and other antioxidants upon topical application have already been studied by authors such as Abla and Gamba [25], these investigations used pig ear skin as a model for human skin penetrability. The authors found that catechin showed the greatest accumulation in the stratum corneum, followed by trans-resveratrol and retinol.…”

Section: Resultsmentioning

confidence: 99%

“…As a result, several attempts have been made to develop formulations to increase its skin penetration [24]. Abla and Banga [25] evaluated the penetration of antioxidants into pig-ear skin, and found decreasing concentrations of catechin, resveratrol and curcumin in the stratum corneum. Approximately 90% of the total amount of polyphenols in the skin was retained in the stratum corneum, with only 10% penetrating the underlying layers of skin.…”

mentioning

confidence: 99%

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Gonçalves¹,

Barros²,

Silva³

et al. 2017

JCDSA

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Plant-derived substances such as curcumin and trans-resveratrol, both of which have anti-inflammatory properties, may have a beneficial effect on human skin. The present study analyzed the effects of topical formulations containing curcumin or trans-resveratrol on the recovery and rejuvenation of skin after chemical peeling. The study was performed on rats, randomly divided into seven groups of six animals each. Superficial peeling was performed using a 50% glycolic acid gel, which was applied to the dorsal region of each animal. Rats were then treated with the experimental formulations for 15 days. On the sixteenth day, skin samples were taken and mounted on slides for histological analysis. Statistical analysis showed that the formulation containing transresveratrol led to increased dermal and epidermal thickness, while the formulation containing curcumin had no effects on epidermal thickness. The increased epidermal thickness may reflect greater skin vitality, although this was not directly evaluated. The increase in dermal thickness may be attributed to greater collagen production, which may increase skin firmness and elasticity, and lead to skin rejuvenation as well as wrinkle reduction. Formulations containing curcumin or trans-resveratrol may have potential for the topical treatment after peeling and of sensitive skin, in addition to being used for their antiaging properties.

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Quantification of skin penetration of antioxidants of varying lipophilicity

Cited by 54 publications

References 47 publications

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

Potential of antioxidant extracts produced by aqueous processing of renewable resources for the formulation of cosmetics

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

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