Quantification of swelling characteristics of pharmaceutical particles

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

“…The dissolution of individual particles of lactose and mannitol was studied using a custom-built flow cell, as described by Soundaranathan et al (2020). Briefly, particles are placed in a small spherical sample holder in the centre of the flow cell.…”

“…The relative swelling for each formulation was calculated using the average particle size (D 50 ) and the maximum swelling capacity (∆r max ). The measurement of ∆r max is described by Soundaranathan et al (2020). The relative swelling was then calculated as the average increase in particle size after wetting, based on the weight fraction of each excipient (c i ).…”

Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

“…The swelling behaviour differs between the four formulations and is driven by the swelling capacity of the individual components. There are only two components used in the studied formulations which swell when they come into contact with liquid: MCC and CCS (Soundaranathan et al, 2020). The swelling observed on the tablet surface is a superposition of the swelling of individual particles and the swelling of particles is only initiated once they are wetted.…”

Simultaneous axial and radial swelling studies from 2D stereozoom images of tablet compacts composed of superdisintegrants

“…Such expansion behaviour is against some findings who states that SSG shows more expansion as compared to CCS. 28 However, their findings are for noncompressed and individual particle-based studies and not for the tablets or powder compacts made up of SSG or CCS.…”