Quantifying Analytes in Paper‐Based Microfluidic Devices Without Using External Electronic Readers

Lewis, Gregory G.; DiTucci, Matthew J.; Phillips, Scott T.

doi:10.1002/anie.201207239

Cited by 158 publications

(139 citation statements)

References 15 publications

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“…Lewis et al 30,32 demonstrated the use of the flow time of the analyte hydrogen peroxide through the detection region for quantitative readout.…”

Section: Time-based Readoutmentioning

confidence: 99%

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Enabling robust quantitative readout in an equipment-free model of device development

2014

Analyst

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A critical constraint in the design of appropriate medical devices for the lowest-resource settings is the lack of access to maintenance or repair on instrumentation. There are numerous point-of-care applications for which quantitative readout would have clinical utility. Thus, a challenge to the device developer is to enable quantitative device readout in an equipment-free model that is appropriate for use in even the lowest-resource settings. Paper microfluidics has great potential for enabling equipment-free devices that are very low-cost, operable by minimally-trained users, and provide quantitative readout. The focus of this critical review is to describe the work, starting several decades ago and continuing to the present, to enable assays with quantitative readout in a fully-disposable device.

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“…Lewis et al 30,32 demonstrated the use of the flow time of the analyte hydrogen peroxide through the detection region for quantitative readout.…”

Section: Time-based Readoutmentioning

confidence: 99%

“…The number of colored bars is proportional to the concentration of analyte hydrogen peroxide. The image is reprinted from Lewis et al 30 , Copyright (2012), with permission from Wiley.…”

Section: Figurementioning

confidence: 99%

Enabling robust quantitative readout in an equipment-free model of device development

2014

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“…Recently there has been extensive research on paper and fiber based microfluidics [4,5]. Paper and fiber material has been reported as a convenient substrate for plethora of microfluidics applications [6,7]. One of the essential elements of microfluidics is driving liquid flow in microchannels.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Passive Micropump for Microfluidics Based Devices

Balyan

Saini

Das

et al. 2016

Collection of Selected Papers of the II International Conference on Information Technology and Nanotechnology

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Abstract. Point-of-care and low cost microfluidics platforms has found an accelerated research focus. One of the essential elements of microfluidics is driving liquid flow in microchannels. Device discussed gives a way to pump liquid passively through a microchannel. The present work represents fiber and paper based passive micro-pumping of liquids through microfluidic devices. The porous structure and network of capillaries inside the paper and fiber materials support spontaneous liquid movement. Agarose gel coating is used with paper in order to achieve variations flow rates. The effect of gel concentration on liquid flow is studied. The concept can be used ubiquitously for microfluidics device application for its low-cost and is feasible to integrate with devices for low resource settings.

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“…Meanwhile, the paper-based analytical device also shows great promises in point-of-care diagnosis since it is easy to use, inexpensive, and designed specifi cally for use in developing countries. [ 15,16 ] Especially, the chromatography paper serves as substances for paper spray ionization by applying a high voltage, in which label-free, rapid, and convenient analysis is implemented by mass spectrometry. [ 17,18 ] Paper spray mass spectrometry (PS-MS) has been recently developed for direct analysis of molecules from complex mixtures with minimum sample pretreatment.…”

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confidence: 99%

Engineering Cell‐Compatible Paper Chips for Cell Culturing, Drug Screening, and Mass Spectrometric Sensing

Chen

Liu

et al. 2015

Adv Healthcare Materials

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Paper-supported cell culture is an unprecedented development for advanced bioassays. This study reports a strategy for in vitro engineering of cell-compatible paper chips that allow for adherent cell culture, quantitative assessment of drug efficiency, and label-free sensing of intracellular molecules via paper spray mass spectrometry. The polycarbonate paper is employed as an excellent alternative bioscaffold for cell distribution, adhesion, and growth, as well as allowing for fluorescence imaging without light scattering. The cell-cultured paper chips are thus amenable to fabricate 3D tissue construction and cocultures by flexible deformation, stacks and assembly by layers of cells. As a result, the successful development of cell-compatible paper chips subsequently offers a uniquely flexible approach for in situ sensing of live cell components by paper spray mass spectrometry, allowing profiling the cellular lipids and quantitative measurement of drug metabolism with minimum sample pretreatment. Consequently, the developed paper chips for adherent cell culture are inexpensive for one-time use, compatible with high throughputs, and amenable to label-free and rapid analysis.

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Quantifying Analytes in Paper‐Based Microfluidic Devices Without Using External Electronic Readers

Cited by 158 publications

References 15 publications

Enabling robust quantitative readout in an equipment-free model of device development

Enabling robust quantitative readout in an equipment-free model of device development

Fabrication and Characterization of Passive Micropump for Microfluidics Based Devices

Engineering Cell‐Compatible Paper Chips for Cell Culturing, Drug Screening, and Mass Spectrometric Sensing

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