Quantifying the association between acute leukemia and serum zinc, copper, and selenium: a meta-analysis

Kim, Sangyoung; Freeland‐Graves, Jeanne H.; Babaei, Mahsa; Sachdev, Prageet K; Beretvas, S. Natasha

doi:10.1080/10428194.2018.1540043

Cited by 17 publications

(17 citation statements)

References 41 publications

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“…Also, laboratory test values, which are currently used for diagnosing HMs, deviated from the reference values in a highly significant way ( P < 0.01, Table 1 ). The alteration of plasma metal concentrations (elevated for Cu and reduced for Zn) and laboratory test values in HM patients are consistent with reported data 5 – 8 , 25 .…”

Section: Resultssupporting

confidence: 92%

“…This pattern for Cu and Zn serum concentrations was also observed in a meta-analysis of bladder cancer 6 and was also associated with an increased risk of oral cancer 7 . Other studies also found serum Cu and/or Zn concentrations deviating from the control range, but without following this specific pattern 5 , 6 , 8 . Despite the large amount of epidemiological data linking metals to HM, their clinical impact on the disease remains unclear.…”

Section: Introductionmentioning

confidence: 88%

“…Cu/Zn SOD is a free radical scavenger, the role of which is maintaining a low level of reactive oxygen species. A meta-analysis on acute leukemia demonstrated that the serum Cu concentration is significantly higher, while that of Zn is significantly lower in patients than in controls 5 . This pattern for Cu and Zn serum concentrations was also observed in a meta-analysis of bladder cancer 6 and was also associated with an increased risk of oral cancer 7 .…”

Section: Introductionmentioning

confidence: 99%

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Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Hastuti

Costas‐Rodríguez

Matsunaga

et al. 2020

Sci Rep

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We have examined potential changes in the isotopic compositions of Fe, Cu and Zn (using multi-collector inductively coupled plasma-mass spectrometry) and the corresponding concentrations (using inductively coupled plasma-atomic emission spectrometry) in plasma from hematological malignancy (HM) patients and assessed their prognostic capability. Together with clinical laboratory test values, data were examined in view of a 5-years survival prediction. Plasma Cu and Zn isotope ratios and their concentrations were significantly different in HM patients compared to matched controls (P < 0.05). Both δ65Cu and δ66Zn values showed significant mortality hazard ratios (HRs) in HM. The group of patients with decreased δ65Cu and increased δ66Zn values showed significantly poorer survival from the early phase (HR 3.9; P = 0.001), forming a unique cohort not identified based on laboratory test values. Well-known prognostic factors for HM, such as the creatinine level, and anemia-related values were highly correlated with the δ66Zn value (P < 0.05). Time-dependent ROC curves based on the δ65Cu or δ66Zn value were similar to that based on the creatinine concentration (a well-known prognostic factor in HM), indicating that δ65Cu or δ66Zn values are useful for prognosis of HM. Variations in stable isotope ratios of essential mineral elements have thus been shown to reflect alterations in their homeostasis due to physiological changes in malignancies with higher sensitivity than concentrations do.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Hastuti

Costas‐Rodríguez

Matsunaga

et al. 2020

Sci Rep

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“…A recent meta‐analysis summarizing results from 16 studies confirmed our finding of hypozincemia in adult leukemic patients, though elevations of serum copper were also often reported in these studies 33 . Reductions in the zinc/copper ratio is not uncommon with zinc deficiency, particularly in inflammatory disorders where copper reacts as an acute phase protein.…”

Section: Discussionsupporting

confidence: 66%

Zinc deficiency and its association with treatment‐related toxicity in children with cancer

Chung

Phalke

Hastings

et al. 2021

Pediatric Blood & Cancer

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“…Trace elements are essential components in the biological structures of cells and have been reported to play important roles in human metabolic and physiological processes [1]. Significant differences in the levels of trace elements have been observed in many diseases such as breast cancer [2], acute leukemia [3], diabetes [4] and Parkinson’s disease [5]. It has been postulated that the pathological events associated to trace elements were driven by activation in pathways closely linked to genotoxicity [6], endocrine modifications [7], receptor mediation [8], immunosuppression [9], tumour promotion [10], tissue-specific toxicity and inflammatory responses [11].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS)

Nawi

Chin

Jamal

2020

Practical Laboratory Medicine

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IntroductionIn recent years, trace elements have gained importance as biomarkers in many chronic diseases. Unfortunately, the requirement for sample volume increases with the extent of investigation either for diagnosis or elucidating the mechanism of the disease. Here, we describe the method development and validation for simultaneous determination of 25 trace elements (lithium [Li], beryllium [Be], magnesium [Mg], aluminium [Al], vanadium [V], chromium [Cr], manganese [Mn], iron [Fe], cobalt [Co], nickel [Ni], copper [Cu], zinc [Zn], gallium [Ga], arsenic [As], selenium [Se], rubidium [Rb], strontium [Sr], silver [Ag], cadmium [Cd], caesium [Cs], barium [Ba], mercury [Hg], thallium [Tl], lead [Pb], uranium [U]) using only 20 μL of human serum.MethodsSerum samples were digested with nitric acid and hydrochloric acid (ratio 1:1, v/v) and analysed by inductively coupled plasma–mass spectrometry (ICP-MS). Seronorm®, a human-derived serum control material was used as quality control samples.ResultsThe coefficient of variations for both intra- and inter-day precisions were consistently <15% for all elements. The validated method was later tested on 30 human serum samples to evaluate its applicability.ConclusionWe have successfully developed and validated a precise and accurate analytical method for determining 25 trace elements requiring very low volume of human serum.

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Quantifying the association between acute leukemia and serum zinc, copper, and selenium: a meta-analysis

Cited by 17 publications

References 41 publications

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Zinc deficiency and its association with treatment‐related toxicity in children with cancer

Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS)

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