Quantitation of Duodenogastric Reflux and Antral Motility by Color Doppler Ultrasonography: Study in Healthy Volunteers and Patients with Gastric Ulcer

Fujimura, Jiro; Haruma, Ken; Hata, Jiro; Yamanaka, Hidetaka; Sumii, Koji; Kajiyama, Goro

doi:10.3109/00365529409094860

Cited by 53 publications

(51 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the various methods of assessing gastric motility or emptying, the advantage of ultrasonography is that it is non-invasive and is readily available in daily practice. Ultrasonography has already been used clinically on humans, and gastric motility has been investigated in patients with functional dyspepsia [17], gastric ulcer [9], and diabetes with metabolic syndrome [26]. In addition, the prokinetic effect of 5HT 4 receptor agonist mosapride citrate was investigated using this ultrasonographic method [16].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonographic evaluation of gastric motility in humans has been applied in clinical settings, and several clinical trials have been performed to estimate the pathogenesis of gastric motility disorders on a large scale [9,16,17,26]. Previous reports have described the ultrasonographic assessment of gastric motility or emptying in dogs [7,19].…”

mentioning

confidence: 99%

“…Postprandial gastric motility is assessed either by quantifying gastric emptying time and/or gastric antral motility or by detecting the electrical excitement caused by gastric movement. Gastric emptying can be evaluated using scintigraphy [1,14], a 13 Coctanoic acid breath test [8,31], or radiopaque markers [18,27], whereas gastric antral motility is examined using force transducers [13] or abdominal ultrasonography [5,7,9,19].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Tsukamoto

Ohno

Tsukagoshi

et al. 2011

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Gastric motility is affected by several pathological conditions which may induce upper gastrointestinal clinical symptoms. The pathogenesis of canine gastric motility disorders is poorly understood because of methodological limitations. This study aimed at establishing a simple method for evaluating postprandial gastric motility in dogs. Gastric motility was ultrasonographically assessed in 7 healthy beagles using a technique previously described in humans. The motility index (MI), an indicator of gastric antral motility, was calculated by measuring the area of the gastric antrum in both a contracted and relaxed phase and by counting the number of contractions. The MI was measured every 30 min for 3 hr after feeding and compared with gastric emptying as assessed by a 13 C-octanoic acid breath test. The MI at 30 min had the lowest variability in the 7 dogs (mean ± SD, 9.77  0.42; coefficient of variance, 4.25%), and a significant correlation was observed with gastric emptying coefficient (R 2 =0.8126, P=0.005) and half-emptying time (R 2 =0.654, P=0.027). When atropine was administered, a significant decrease in the MI at 30 min was observed compared with the control (9.77  0.42 vs. 5.19  0.22, P=0.0003). In conclusion, evaluation of the MI at 30 min is suitable for assessing gastric motility and enables us to assess gastric motility simply in a short time. By using this method, further studies for the pathogenesis of canine gastric motility disorders are warranted.KEY WORDS: 13 C-octanoic acid breath test, canine, gastric motility, motility index, ultrasonography.J. Vet. Med. Sci. 73(9): 1133-1138, 2011 Gastric motility disorders are caused secondary by several diseases or drug administration and possibly related with the pathogenesis of upper gastrointestinal clinical symptoms such as anorexia, vomiting, abdominal pain, and emesis. Several methods for evaluating gastric motility in both humans and dogs have been described [25,29]. Gastric motor activity has 2 characteristic phases: fasting and the postprandial phase. Many of the previous studies have focused on the postprandial phase. Postprandial gastric motility is assessed either by quantifying gastric emptying time and/or gastric antral motility or by detecting the electrical excitement caused by gastric movement. Gastric emptying can be evaluated using scintigraphy [1,14], a 13 Coctanoic acid breath test [8,31], or radiopaque markers [18,27], whereas gastric antral motility is examined using force transducers [13] or abdominal ultrasonography [5,7,9,19].Of these methods, scintigraphy is considered the gold standard for evaluating gastric emptying in both humans and dogs [22,29]. However, it requires a specialized facility and exposure to radiation. The 13 C-octanoic acid breath test is an indirect method of assessing gastric emptying using a non-radioisotope-labeled substrate. The test involves monitoring the rate of 13 CO 2 in expired air following ingestion of a test meal mixed with 13 C-octanoic acid. The 13 C-octanoic acid breath test has ...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Tsukamoto

Ohno

Tsukagoshi

et al. 2011

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…In our previous study, we reported that extracorporeal ultrasonography (US) is a useful modality for the assessment of meal-induced gastric AR, gastric emptying rate (GER), antral contractions, and duodenogastric reflux (DGR) (17)(18)(19)(20)(21)(22). The aim of this study was to determine the clinical effects of Rikkunshito on gastric AR and gastroduodenal motility in FD patients by using US.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

et al. 2010

View full text Add to dashboard Cite

Background Rikkunshito, a traditional Japanese (Kampo) medicine, is widely prescribed as an oral preparation for the treatment of functional dyspepsia (FD). In our previous study, we reported that extracorporeal ultrasonography (US) is a useful technique for the assessment of the gastric accommodation reflex (AR) and duodenogastric motility. In this study, we examined the effects of Rikkunshito on the gastroduodenal function in patients with FD. Methods Sixteen FD patients (median age, 45 y) underwent US, before and after 14 days of treatment with Rikkunshito (7.5 g b.d.). For assessment of the AR, a cross-sectional area of the proximal stomach was measured after incremental ingestion of a liquid meal up to 400-mL. The expansion rate was used as the parameter to determine the AR. Then, the gastric emptying rate (GER), motility index (MI), and reflux index (RI) were evaluated using previously reported methods. Results Although no significant changes were observed in the total score of the Gastrointestinal Symptom Rating Scale (GSRS), the scores of 3 of the 15 symptoms of GSRS decreased significantly after treatment with Rikkunshito. The expansion rate of the proximal stomach was significantly greater after treatment with Rikkunshito than before the treatment. Although the GER and MI increased significantly, no significant differences in the RI were observed after treatment with Rikkunshito. Conclusion These observations suggested that Rikkunshito may be beneficial for the treatment of FD patients with impaired AR and gastric motility. These results also suggested that Rikkunshito has a therapeutic potential for FD and GERD.

show abstract

“…But recent technical developments enable one to evaluate gastroduodenal motility by using ultrasonography, which is simple and noninvasive. In human medicine, since Bateman & Whittingham [2] first reported the measurement of gastric emptying by ultrasonography and video tape recording, it also has been possible to observe the movement of pyloric fluid by ultrasonography [8]. Especially, Bolondi et al [4] reported that ultrasound study of the antropyloric region based on measurements of the cross section area of gastric antrum and the volume of the whole antropyloric region allowed accurate determination of total gastric emptying time (GET) in human beings.…”

mentioning

confidence: 99%

Evaluation of Canine Gastric Motility with Ultrasonography.

et al. 2002

View full text Add to dashboard Cite

ABSTRACT. For the evaluation of canine gastric motility with ultrasonography, contraction number of pyloric antrum and gastric emptying time (GET) by area and volume method developed by Bolondi et al.'s method were studied in 14 dogs. All experimental dogs were administered with saline and soup solution (10 ml/kg, B.W.). The mean values of contraction number of pyloric antrum in saline and soup group were 4.19 ± 1.30/min and 4.82 ± 0.65/min before feeding, and overall mean values were 4.66 ± 1.37/min and 5.13 ± 1.71/ min, respectively. The mean values of the GET by area and volume method were 36.73 ± 11.27, 40.00 ± 8.87 min in saline group and 61.35 ± 17.58, 59.11 ± 14.46 min in soup group. In the GET in saline and soup groups, there was no significant difference between the area and volume method (p>0.05). Therefore, Bolondi et al.'s method by ultrasound can be used to evaluate the antropyloric motility and gastric emptying time with area and volume methods. The area method is easier to determine the GET than the volume method, but the latter is more accurate.

show abstract

Quantitation of Duodenogastric Reflux and Antral Motility by Color Doppler Ultrasonography: Study in Healthy Volunteers and Patients with Gastric Ulcer

Abstract: Ultrasonography with color Doppler is useful for evaluating abnormalities of gastroduodenal motility and can be used to understand the pathogenesis of such disorders.

Cited by 53 publications

References 29 publications

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

Evaluation of Canine Gastric Motility with Ultrasonography.

Contact Info

Product

Resources

About