Quantitation of pharmaceutically important phenothiazines by oxidimetry

Basavaiah, K.; Swamy, Javarappa Manjunatha; Krishnamurthy, G.

doi:10.1016/s0014-827x(99)00122-6

Cited by 21 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Basavaiah et al 48,49 proposed two indirect spectrophotometric methods for the determination of phenothiazines with K2Cr2O7. The methods are based on the following: • The oxidation of the 2,10-disubstituted drugs by a known excess of chromium(VI), and a subsequent determination of the unreacted oxidant by interacting with methanol and sulfanilic acid;…”

mentioning

confidence: 99%

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Puzanowska-Tarasiewicz

Kuźmicka

Karpińska

et al. 2005

ANAL. SCI.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Puzanowska-Tarasiewicz

Kuźmicka

Karpińska

et al. 2005

ANAL. SCI.

View full text Add to dashboard Cite

“…Potassium dichromate has been a useful oxidizing agent in the determination of a number of substances of pharmaceutical importance [26][27][28][29][30]. All the four methods described here are indirect and are based on the determination of residual dichromate after allowing the reaction between a measured excess of dichromate and RNH to go to completion under acidic conditions.…”

Section: Resultsmentioning

confidence: 99%

Quantitation of ranitidine in pharmaceuticals by titrimetry and spectrophotometry using potassium dichromate as the oxidimetric reagent

Basavaiah

Somashekar

2007

JICS

View full text Add to dashboard Cite

Four new methods are described for the determination of ranitidine hydrochloride (RNH) in bulk drug and in formulations employing titrimetric and spectrophotometric techniques and using potassium dichromate as the oxidimetric reagent. In titrimetry (method A), RNH is treated with a measured excess of dichromate in acid medium, and the unreacted oxidant is back titrated with iron(II) ammonium sulfate. The three spectrophotometric methods are also based on the oxidation of RNH by a known excess of dichromate under acidic conditions followed by the determination of surplus oxidant by three different reaction schemes. In one procedure (method B), the residual dichromate is treated with diphenylcarbazide and the absorbance measured at 540 nm. Calculated amount of iron(II) is added to residual dichromate and the resulting iron(III) is complexed with thiocyanate and measured at 470 nm (method C). Method D involves reduction of unreacted dichromate by a calculated amount of iron(II) and estimation of residual iron(II) as its orthophenanthroline complex after raising the pH, and measuring the absorbance at 510 nm. In all the methods, the amount of dichromate reacted corresponds to the drug content. The experimental conditions are optimized. The titrimetric procedure is applicable over 5-10 mg range. In spectrophotometric methods, Beer's law is obeyed in the ranges 5-50, 5-80, and 10-100 μg ml -1 for method B, method C, and method D, respectively. The methods were validated for accuracy, precision and recovery. The proposed methods were applied to the analysis of RNH in the tablet and the injection forms, and the results were in agreement with those obtained by the reference method.

show abstract

“…The versatility of Chloramine-T as an analytical reagent can be gauged by its applications in the titrimetric [27][28][29][30][31][32][33] and spectrophotometric [34][35][36][37][38][39][40] determination of many oragnic compounds of therapeutic importance. The use depends mainly on its ability to effect the oxidation of diverse functional groups.…”

Section: Resultsmentioning

confidence: 99%

Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

Basavaiah

Prameela

2003

ANAL. SCI.

View full text Add to dashboard Cite

Quantitation of pharmaceutically important phenothiazines by oxidimetry

Cited by 21 publications

References 19 publications

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Efficient Oxidizing Agents for Determination of 2,10-Disubstituted Phenothiazines

Quantitation of ranitidine in pharmaceuticals by titrimetry and spectrophotometry using potassium dichromate as the oxidimetric reagent

Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

Contact Info

Product

Resources

About