Quantitative analysis of axon collaterals of single superficial pyramidal cells in layer IIb of the piriform cortex of the guinea pig

Quraish, Afraz ul; Yang, Jincheng; Murakami, Kunio; Oda, Satoko; Takayanagi, Masayoshi; Kimura, Akihiko; Kakuta, Sachiko; Kawakami, Kiyoshi

doi:10.1016/j.brainres.2004.07.085

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…A final intriguing point is that there is a distinct lack of functional projections from pPC to aPC. This is consistent with anatomical evidence based on reconstructions of axon collaterals of individual pPC neurons, as well as bulk tracer labeling (Datiche et al, 1996; Johnson et al, 2000; Chen et al, 2003; ul Quraish et al, 2004; Yang et al, 2004). …”

Section: Discussionsupporting

confidence: 86%

“…By contrast, single neuron injections, which are technically more difficult, are better suited for detailed analysis of intrinsic connectivity. Indeed, single neuron fills clearly reveal abundant local axonal arbors of pPC neurons (Johnson et al, 2000; Chen et al, 2003; ul Quraish et al, 2004; Yang et al, 2004). Taken together, anatomical studies note a caudal bias in the associational projections from the pPC, but leave open the possibility of strong local intrinsic connections.…”

Section: Discussionmentioning

confidence: 99%

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Optophysiological analysis of associational circuits in the olfactory cortex

Hagiwara

Pal

Sato

et al. 2012

Front. Neural Circuits

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Primary olfactory cortical areas receive direct input from the olfactory bulb, but also have extensive associational connections that have been mainly studied with classical anatomical methods. Here, we shed light on the functional properties of associational connections in the anterior and posterior piriform cortices (aPC and pPC) using optophysiological methods. We found that the aPC receives dense functional connections from the anterior olfactory nucleus (AON), a major hub in olfactory cortical circuits. The local recurrent connectivity within the aPC, long invoked in cortical autoassociative models, is sparse and weak. By contrast, the pPC receives negligible input from the AON, but has dense connections from the aPC as well as more local recurrent connections than the aPC. Finally, there are negligible functional connections from the pPC to aPC. Our study provides a circuit basis for a more sensory role for the aPC in odor processing and an associative role for the pPC.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Optophysiological analysis of associational circuits in the olfactory cortex

Hagiwara

Pal

Sato

et al. 2012

Front. Neural Circuits

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“…4 C, box and higher magnification), which expressed EYFP+ spines (arrows in Fig 4C1, Fig 8A1-A2), penetrated through layer II and layer Ib into layer Ia (Fig. 4 C2), where they presumably formed synapses with axons extended from OB mitral cells (ul Quraish et al, 2004). The above data clearly demonstrated the presence of EYFP+ neurons in the piriform cortex.…”

Section: Resultsmentioning

confidence: 99%

Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

Guo¹,

Maeda²,

Ma³

et al. 2010

J. Neurosci.

161

162

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Previous studies have shown that oligodendroglial progenitor cells (OPCs) can give rise to neurons in vitro and in perinatal cerebral cortex in vivo. We now report that OPCs in adult murine piriform cortex express low levels of doublecortin, a marker for migratory and immature neurons. Additionally, these OPCs express Sox2, a neural stem cell marker, and Pax6, a transcription factor characteristic of progenitors for cortical glutamatergic neurons. Genetic fate-mapping by means of an inducible Cre-LoxP recombination system proved that these OPCs differentiate into pyramidal glutamatergic neurons in piriform cortex. Several lines of evidence indicated that these newly formed neurons became functionally integrated into the cortical neuronal network. Our data suggest that NG2 ϩ /PDGFR␣ ϩ proteolipid protein promoter-expressing progenitors generate pyramidal glutamatergic neurons within normal adult piriform cortex.

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“…However, it is unclear which neuron types contribute to the numerous projections out of the APC. Reconstruction studies of individual neurons suggest that APC principal cells project axons to the OB, the AON, and to downstream olfactory regions such as the PPC, LEnt, and CoA 21,22 . However, it is unclear how prevalent are these cells that project both anterogradely and retrogradely.…”

Section: Introductionmentioning

confidence: 99%

Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex

Mazo

Grimaud

Murthy

et al. 2017

Preprint

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Processing of olfactory information in the anterior piriform cortex (APC) is widely thought to be nontopographic due to distributed projections from the olfactory bulb (OB). Layer 2 principal neurons in the APC can be divided into 2 subtypes: semilunar (SL) and superficial pyramidal (SP) cells. Although it is known that SL and SP cells receive differential inputs from the OB, little is known about their projection pattern to downstream structures, such as the posterior piriform cortex (PPC). Here we examined feedforward and feedback axonal projections of SL and SP cells using a combination of mouse genetics, and retrograde labeling. Retrograde tracing from the OB or PPC showed that the APC projects to these higher and lower brain regions mainly through layer 2b cells, while dual-labeling revealed a sizeable fraction of cells extending collaterals to both target regions. Furthermore, a transgenic mouse line specifically labeling SL cells showed that they send profuse axonal projections to olfactory cortical areas, but not to the OB. These findings support a model in which information flow from SL to SP cells and back to the OB forms a hierarchical feedback circuit whereas the two cell types process recurrent and feedforward information in a parallel manner.

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Quantitative analysis of axon collaterals of single superficial pyramidal cells in layer IIb of the piriform cortex of the guinea pig

Cited by 13 publications

References 31 publications

Optophysiological analysis of associational circuits in the olfactory cortex

Optophysiological analysis of associational circuits in the olfactory cortex

Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex

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