Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

Abstract

Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm 3) at follow-up minus PV at index > 0. Annual change of PV (mm 3 /year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group

Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

“…Accumulating evidence indicated that the elevated TyG index was linked to accelerated atherosclerosis. The study of Won et al ( 11 ) found that patients with elevated TyG index had a more remarkable increase in coronary plaque volume. The study of Lee et al ( 48 ) demonstrated that there was a >3-fold increase in the incidence of coronary artery stenosis in subjects with elevated TyG index.…”

“…Recently, a novel convenient biomarker of IR, Triglycerideglucose (TyG) index calculated by the formula ln [fasting triglycerides (mg/dl) × fasting plasma glucose (mg/dl)/2], has elicited the interests of researchers because of its superior performance in the estimation of IR than a homeostatic model assessment of IR (HOMA-IR) (6)(7)(8)(9). Certain studies in humans showed that TyG index was positively correlated with coronary artery calcification (10), coronary plaque progression (11), and subclinical myocardial injury (12), providing plausibility of the prognostic significance of TyG index in CAD. As a product of triglycerides and plasma glucose, the TyG index may provide additional information for the risk assessment of adverse cardiovascular events.…”

Triglyceride-glucose index and the risk of stroke and its subtypes in the general population: an 11-year follow-up

“…Firstly, insulin resistance led to the chronic inflammation [ 18 ], endothelium dysfunction [ 19 – 21 ], facilitated the formation of foam cells in the initiation of atherosclerosis [ 22 ] and promoted the vulnerable plaque [ 23 ]. Previous studies indicated that TyG index was associated with increased arterial stiffness in general population [ 24 , 25 ] and an independent predictive marker for plaque progress [ 26 ], which could contribute to the occurrence of stroke. Secondly, previous research showed that insulin resistance affected platelet adhesion, activation and aggregation [ 27 – 29 ] which were associated with artery stenosis or occlusion and involved in stroke occurrence.…”

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

“…In addition, Won et al . reported that the participants with the highest tertile TyG index had a 1.65-fold higher risk of coronary PP and 1.78-fold of rapid PP compared with the lowest tertile [ 34 ]. However, to our knowledge, little is currently known about the relationship between TyG index and arterial stiffness progression.…”