Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI

Hatabu, Hiroto; Tadamura, Eiji; Levin, David L.; Chen, Qun; Li, Wei; Kim, Ducksoo; Prasad, Pottumarthi V.; Edelman, Robert R.

doi:10.1002/(sici)1522-2594(199912)42:6<1033::aid-mrm7>3.0.co;2-7

Cited by 172 publications

(137 citation statements)

References 18 publications

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“…The obtained perfusion rates are in good agreement with recent publications (7,(22)(23)(24). If one considers a total lung volume in deep expiration of 2-3 L and a total circulation volume of 5-6 L/min, one obtains perfusion rates of Ϸ2 mL/min/mL.…”

Section: Discussionsupporting

confidence: 89%

“…The proof of principle for obtaining pulmonary perfusion using MRI was demonstrated in 1985 (1). In the years since this pioneer work, two basic perfusion imaging methods have been established: The arterial spin labeling (ASL) techniques (2,3), which use blood as an endogenous contrast-agent, and imaging techniques in conjunction with the application of contrast-altering substances (eg, Gd-DTPA) (4,5). However, both strategies suffer from certain disadvantages.…”

mentioning

confidence: 99%

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Assessment of pulmonary perfusion in a single shot using SEEPAGE

Fischer¹,

Pracht²,

Arnold³

et al. 2007

Magnetic Resonance Imaging

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Purpose: To present a single-shot perfusion imaging sequence that does not require contrast agents or a subtraction of a tag and a control image to create the perfusionweighted contrast. The proposed method is based on SEEPAGE. Materials and Methods:Experiments with healthy volunteers were performed to qualitatively and quantitatively obtain pulmonary perfusion values in coronal as well as sagittal orientation. In addition, a first experiment with a lung cancer patient was performed to explore the potentials of SEEPAGE in a clinical application. Results:All experiments clearly showed a perfusionweighted contrast, providing clinical quality images with high spatial resolution. The quantified perfusion rates were consistent in the different imaging orientations and covered the interval of 1.00 -4.00 mL/min/mL. In addition, the gravitational dependence of pulmonary perfusion, the influence of adiabatic pulse duration on signal intensity, and the tracer saturation effect were examined. In the patient examination the presented technique provided additional information of the lung deficiency compared to a conventional anatomical image.Conclusion: SEEPAGE has proved to be a robust and reproducible technique for obtaining perfusion-weighted images in a single measurement and for quantifying pulmonary perfusion using an additional reference scan. Furthermore, the proposed method shows promise for future clinical application.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Assessment of pulmonary perfusion in a single shot using SEEPAGE

Fischer¹,

Pracht²,

Arnold³

et al. 2007

Magnetic Resonance Imaging

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“…The development of high-speed gradient systems and fast imaging methods has permitted ultrafast contrast-enhanced lung perfusion imaging with subsecond temporal resolution and millimeter spatial resolution (1)(2)(3)(4)(5)(6)(7)(8). Imaging of the lung parenchyma suffers from low proton density, physiological motion (cardiac and respiratory motion adjacent to the lung), and short T* 2 from local magnetic field inhomogeneity due to multiple interfaces of air and soft tissues (3,9 -12); significantly reduced times TR and TE in the gradient-echo sequence allow dramatically improved SNR.…”

mentioning

confidence: 99%

Combined MR proton lung perfusion/angiography and helium ventilation: Potential for detecting pulmonary emboli and ventilation defects

Zheng

Leawoods

Nolte

et al. 2002

Magnetic Resonance in Med

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Three-dimensional (3D) perfusion imaging allows the assessment of pulmonary blood flow in parenchyma and main pulmonary arteries simultaneously. MRI using laser-polarized 3 He gas clearly shows the ventilation distribution with high signal-tonoise ratio (SNR). In this report, the feasibility of combined lung MR angiography, perfusion, and ventilation imaging is demonstrated in a porcine model. Ultrafast gradient-echo sequences have been used for 3D perfusion and angiographic imaging, in conjunction with the use of contrast agent injections. 2D multiple-section 3 He imaging was performed subsequently by inhalation of 450 ml of hyperpolarized 3 He gas. The MR techniques were examined in a series of porcine models with externally delivered pulmonary emboli and/or airway occlusions. The development of high-speed gradient systems and fast imaging methods has permitted ultrafast contrast-enhanced lung perfusion imaging with subsecond temporal resolution and millimeter spatial resolution (1-8). Imaging of the lung parenchyma suffers from low proton density, physiological motion (cardiac and respiratory motion adjacent to the lung), and short T* 2 from local magnetic field inhomogeneity due to multiple interfaces of air and soft tissues (3,9 -12); significantly reduced times TR and TE in the gradient-echo sequence allow dramatically improved SNR. Recently, bolus injection of gadolinium contrast agent in conjunction with an ultrafast 3D gradient-echo sequence has demonstrated volumetric lung parenchymal perfusion images with 2-3 sec temporal resolution (7). This technique allows simultaneous evaluation of lung perfusion and flow in the major pulmonary vasculature. On the other hand, submillimeter high-spatial-resolution pulmonary angiography has been achieved with bolus administration of gadolinium contrast agent and first-pass MR data acquisition during the arterial phase of the contrast agent (13-15). This contrast-enhanced pulmonary angiography shows high SNR and can depict pulmonary arteries beyond the subsegmental branches. Integration of perfusion and angiography may allow better evaluation of parenchymal blood flow states and vasculature involvement; this is particularly interesting when pulmonary emboli are studied (10,16).The ability of MR to image the lung air space is important for the diagnosis of a variety of pulmonary ventilation abnormalities. Recently, assessment of regional lung ventilation using hyperpolarized noble gas has emerged as an imaging technique for evaluating patients with lung disease, such as tumor, emphysema, bronchiectasis, cystic fibrosis, and asthma (17-24). Compared to O 2 -enhanced lung MRI (25,26), which has the advantage of needing no special equipment, 3 He MRI provides high SNR and contrast-to-noise ratio (CNR), with image intensity directly proportional to the local concentration of inhaled 3 He. It has long been recognized that both pulmonary perfusion and ventilation images are needed to identify and distinguish certain lung diseases. For example, mismatched and matched perfusi...

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“…The other data collection regime, referred to as residue detection, is typically used, alone or in conjunction with inlet detection, for analysis of microvascular regions wherein the individual vessels are below the resolution of the imaging system. Various approaches for determining blood flow and/or mean transit time have been described (114,(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127). There have been a growing number of studies, demonstrating the use of MDCT with infusion of iodinated contrast agent to assess the presence of pulmonary emboli via visualization of flow voids in peripheral lung segments, and the improved ability to detect pulmonary emboli, aortic dissection and coronary atherosclerosis have resulted in the "triple ruleout" method for use in patients with chest pain (128).…”

Section: Ventilation Assessed By Ctmentioning

confidence: 99%

Functional Imaging: CT and MRI

Beek

Hoffman

2008

Clinics in Chest Medicine

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Synopsis-Numerous imaging techniques permit evaluation of regional pulmonary function. Contrast-enhanced CT methods now allow assessment of vasculature and lung perfusion. Techniques using spirometric controlled MDCT allow for quantification of presence and distribution of parenchymal and airway pathology, Xenon gas can be employed to assess regional ventilation of the lungs and rapid bolus injections of iodinated contrast agent can provide quantitative measure of regional parenchymal perfusion. Advances in magnetic resonance imaging (MRI) of the lung include gadolinium-enhanced perfusion imaging and hyperpolarized helium imaging, which can allow imaging of pulmonary ventilation and .measurement of the size of emphysematous spaces.

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Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI

Cited by 172 publications

References 18 publications

Assessment of pulmonary perfusion in a single shot using SEEPAGE

Assessment of pulmonary perfusion in a single shot using SEEPAGE

Combined MR proton lung perfusion/angiography and helium ventilation: Potential for detecting pulmonary emboli and ventilation defects

Functional Imaging: CT and MRI

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