Quantitative Bone Single Photon Emission Computed Tomography/Computed Tomography for Evaluating Response to Bisphosphonate Treatment in Patients with Paget’s Disease of Bone

Kitajima, Kazuhiro; Futani, Hiroyuki; Tsuchitani, Tatsuya; Takahashi, Yoshiyuki; Yamakado, Koichiro

doi:10.1159/000507663

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…To accurately convert SPECT counts to QSVs without ACSC, these effects must be considered when measuring the CCF, that is, the CCF should be calculated using SB-phantom, and the interpretation with QSVs must be applied only to a limited region such as the lumbar spine. Owing to the high accuracy of quantitative bone SPECT using the SPECT/CT system, most studies of quantitative bone SPECT have previously relied on ACSC with the SPECT/CT system [3–5,8,17–20], while few reports on the SPECT-alone system that is still widely used today have been published [13]. To the best of our knowledge, this is the first study to focus on the CCF measurement in quantitative bone SPECT without ACSC.…”

Section: Discussionmentioning

confidence: 99%

“…Quantitative techniques using cross-calibration have been used in the past with cerebral blood flow SPECT [9] and have now begun to be used as a common method in quantitative bone SPECT [6,8]. Although only available in certain devices, quantitative bone SPECT with xSPECT BONE technology has also attracted attention [5].…”

Section: Introductionmentioning

confidence: 99%

“…For the diagnosis of bone metastases, many studies have demonstrated the effectiveness of SUV measurements in bone SPECT. The advantages of quantitative bone SPECT are to facilitate the distinction between benign and malignant accumulations by establishing numerical thresholds, permit reliable dosimetry for radionuclide therapy, and facilitate comparisons for follow-up [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction

Ichikawa

Onoguchi

Shibutani

et al. 2021

Nuclear Medicine Communications

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Objectives Quantitative single-photon emission computed tomography (SPECT) with computed tomography (SPECT/CT) is known to improve diagnostic performance. Although SPECT-alone systems are used widely, accurate quantitative SPECT using these systems is challenging. This study aimed to improve the accuracy of quantitative bone SPECT of the lumbar spine with the SPECT-alone system. Methods The cross-calibration factor (CCF) was measured using three kinds of phantoms and the optimal values were determined. The recovery coefficient with and without attenuation and scatter correction (ACSC) were compared. Bone SPECT/CT was performed on 93 consecutive patients with prostate cancer, and the standardized uptake values (SUVs) were compared using the respective CCFs. The first 60 patients were classified according to body weight, and the correlation coefficient between SUVs with and without ACSC were calculated; the slopes were defined as body weight-based coefficients (BWCs). In the remaining 33 patients, the SUV was adjusted according to BWC, and the accuracy of the adjustment was verified. Results The quantitative SPECT values obtained from the CCF using SIM2 bone phantom showed nearly accurate radioactivity concentrations, even without ACSC. The recovery coefficients with and without ACSC were similar. Unadjusted SUVs with and without ACSC were strongly correlated; however, SUVs without ACSC were significantly higher than those with ACSC (P < 0.0001). The mean difference between the SUVs with and without ACSC disappeared when the SUVs without ACSC were adjusted by BWC (P = 0.9814). Conclusions Our cross-calibration method for quantitative bone SPECT enables interpretation with a harmonized SUV even in SPECT-alone systems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction

Ichikawa

Onoguchi

Shibutani

et al. 2021

Nuclear Medicine Communications

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show abstract

“…SPECT/CT data were analyzed using a commercially available software package (GI-BONE, Aze Co., Ltd, Tokyo, Japan), which provides statistics for various SUVs, such as max, peak, and mean SUV, as well as metabolic bone volume (MBV) and total bone uptake (TBU). 7 SUVmax was defined as the maximum concentration in the target lesion (maximum radioactivity/voxel volume)/(injected radioactivity/body weight). SUVpeak is defined as average activity concentration within a 1 cm 3 spherical VOI centered on the “hottest focus” within the tumor.…”

Section: Case Reportmentioning

confidence: 99%

Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis

Komoto

Kitajima

Azuma

et al. 2022

Acta Radiologica Open

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We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by −56%, −56%, −50%, −12%, and −58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.

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“…However, several recently published studies have provided evidence of a significant contribution of absolute quantification in the interpretation of bone SPECT images, especially for the monitoring of longitudinal changes after treatment (3)(4)(5) and also for the characterization of metastasis (6)(7)(8), osteomyelitis, osteonecrosis (9), and certain degenerative bone lesions (10,11). All these previous quantitative bone SPECT studies were conducted with conventional Anger cameras, and none has presented an image display using an SUV scale and with whole-body recording times adapted to routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

Bone Scintigraphy of Vertebral Fractures With a Whole-Body CZT Camera in a PET-Like Utilization

et al. 2021

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Objective: An image display with a standardized uptake value (SUV) scale is recommended for analyzing PET exams, thus requiring the reconstruction of accurate images for both SUV measurement and visual analysis. This study aimed to determine whether such images may also be obtained with a high-speed CZT-SPECT/CT system, with a further application for the longitudinal monitoring of vertebral fractures.Materials and Methods: SPECT image reconstruction was optimized with an IEC phantom according to both image quality parameters and accuracy of measured activity. The optimized reconstruction process was applied to ≤15 min 99mTc-HDP SPECT spine recordings previously acquired from 25 patients (74 ± 12 years old) at both early (1.3 ± 1.1 months) and late (5.2 ± 2.3 months) stages after an acute vertebral fracture.Results: A SPECT reconstruction with 32 equivalent iterations was selected based on the association of high detectability for spheres down to 0.6 ml in volume, with accurate measured activity, although the latter was affected by partial volume effect for spheres ≤5.6 ml. Coherent measurements were obtained on these high-quality SPECT images for the SUVmax from the intact vertebrae of patients, which were stable between basal SPECT/CT and follow-up SPECT/CT (for T1 vertebrae: 5.7 ± 1.1 vs. 5.8 ± 1.1, p = 0.76), and from initially fractured vertebrae, which were dramatically higher on the basal compared with the follow-up SPECT (21.0 ± 8.5 vs. 11.2 ± 4.2, p < 0.001), whereas inverse changes in SUVmax were observed for newly compacted fractures identified on follow-up SPECT (74.4 ± 2.0 vs. 21.8 ± 10.3, p = 0.002). Finally, an image display with an SUV scale was shown to be advantageous for highlighting areas with >7.5 SUV, a level reached by 98% of vertebral fractures of <7 months and 4% of reference intact vertebrae.Conclusion: Bone scintigraphy of vertebral fractures may be obtained with this CZT-SPECT/CT system with fast 3D acquisitions and high-quality images displayed with a reliable SUV scale, approaching what is achieved and recommended for PET imaging.

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Quantitative Bone Single Photon Emission Computed Tomography/Computed Tomography for Evaluating Response to Bisphosphonate Treatment in Patients with Paget’s Disease of Bone

Cited by 10 publications

References 7 publications

Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction

Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction

Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis

Bone Scintigraphy of Vertebral Fractures With a Whole-Body CZT Camera in a PET-Like Utilization

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