In this note, we derive a stability and weak-strong uniqueness principle for volume-preserving mean curvature flow. The proof is based on a new notion of volumepreserving gradient flow calibrations, which is a natural extension of the concept in the case without volume preservation recently introduced by Fischer et al. [arXiv:2003.05478]. The first main result shows that any strong solution with certain regularity is calibrated. The second main result consists of a stability estimate in terms of a relative entropy, which is valid in the class of distributional solutions to volume-preserving mean curvature flow.