Quantitative determination of chromium picolinate in animal feeds by solid phase extraction and liquid chromatography-tandem mass spectrometry

Han, Miaomiao; Tian, Yingli; Li, Zhen; Chen, Yiqiang; Yang, Weijie; Zhang, Liying

doi:10.1016/j.jchromb.2017.10.039

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…As the matrix of the feed is rich in ingredients such as carbohydrates, proteins, lipids, vitamins and minerals, an effective purification method should generally be applied during sample preparation . Many sample pretreatment techniques including solid‐liquid extraction , SPE , matrix solid‐phase dispersion extraction and pressurized‐liquid extraction (PLE) are typically used for the preparation of feed samples. However, most of these approaches are laborious, time‐consuming and expensive to apply .…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of nosiheptide in feed based on dispersive SPE coupled with HPLC

Xie

Song

Zhang

et al. 2018

J of Separation Science

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A novel, simple, and reliable method based on high‐performance liquid chromatography coupled with fluorescence detection has been developed for the determination of nosiheptide in feed. The feed samples were extracted with acetonitrile 0.1% formic acid aqueous solution and then purified via a dispersive solid‐phase extraction procedure using silica gel powder as the sorbent. Using a mixture of acetonitrile and 5 mM ammonium acetate solution (containing 0.1% formic acid) as the mobile phase, good separation and peak shape were obtained for nosiheptide on a Poroshell C8 column (250 × 4.6 mm id, 4 μm) via the isocratic elution program. The resulting calibration curve shows high levels of linearity (r2 > 0.999) for nosiheptide concentrations of 50–1000 μg/L. At three spiked levels, i.e., 0.500, 2.50 and 5.00 mg/kg, the intra‐ and interday recoveries of nosiheptide in five types of feed ranged from 78.5–96.8 and 84.9–94.2%, respectively. The intra‐ and interday relative standard deviations were less than 10.8%. The limits of quantification for nosiheptide in complete feed and premixes were measured as 50 and 100 μg/kg, respectively. Compared with other common adsorbents, silica gel presents stronger recovery and purification results for feed samples during the dispersive solid‐phase extraction process.

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Section: Introductionmentioning

confidence: 99%

Rapid determination of nosiheptide in feed based on dispersive SPE coupled with HPLC

Xie

Song

Zhang

et al. 2018

J of Separation Science

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Simultaneous determination of amantadine and rimantadine in feed by liquid chromatography-Qtrap mass spectrometry with information-dependent acquisition

Jia

Wang

et al. 2018

Anal Bioanal Chem

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A sensitive method for simultaneous determination of amantadine and rimantadine in feed was developed using an ultra-high-performance liquid chromatography-triple quadrupole linear ion trap mass spectrometry (UHPLC-Qtrap-MS) in the multiple reaction monitoring information-dependent acquisition-enhanced product ion (MRM-IDA-EPI) mode, and employing the mixed cation exchange (MCX) solid-phase extraction column as sample cleanup and amantadine-d and rimantadine-d as internal standards, respectively. Compared to traditional MRM mode, for the targeted drugs in feed simultaneously both the secondary mass spectra and MRM information can be obtained using UHPLC-Qtrap-MS with MRM-IDA-EPI mode, and thus more accurate qualitative confirmation results achieved even at lower concentration of 0.2 μg/L in acceptable purity fit values. After optimization of sample preparation, good linearities (R > 0.9994) were obtained over the concentration range from 1 to 200 μg/L for amantadine and rimantadine. The precision was validated by intra-day and inter-day, and the relative standard deviations were all within 9.61%. Mean recoveries ranged from 76.1 to 112% at spiked concentrations of 0.5-100 μg/kg in three types of feed samples, including formula feed and complex concentrated feed for pigs and premix feed for chicken. The limits of detection (LODs) and quantification (LOQs) were 0.2 and 0.5 μg/kg for both drugs, respectively. The application in real feed samples further proved the accuracy and reliability of the developed method. This method provides an important tool to detect illegal uses of amantadine and rimantadine in feed. Graphical abstract Simultaneous quantitation and qualitative confirmation of amantadine and rimantadine in feed by MRM-IDA-EPI.

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Determination of chromium picolinate and trace hexavalent chromium in multivitamins and supplements by HPLC-ICP-QQQ-MS

Mihai

Kawamoto

LeBlanc

et al. 2020

Journal of Food Composition and Analysis

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Quantitative determination of chromium picolinate in animal feeds by solid phase extraction and liquid chromatography-tandem mass spectrometry

Cited by 8 publications

References 16 publications

Rapid determination of nosiheptide in feed based on dispersive SPE coupled with HPLC

Rapid determination of nosiheptide in feed based on dispersive SPE coupled with HPLC

Simultaneous determination of amantadine and rimantadine in feed by liquid chromatography-Qtrap mass spectrometry with information-dependent acquisition

Determination of chromium picolinate and trace hexavalent chromium in multivitamins and supplements by HPLC-ICP-QQQ-MS

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