Quantitative estimation of mercury intake by toxicokinetic modelling based on total mercury levels in humans

Abass, Khaled; Huusko, Antti; Knutsen, Helle Katrine; Nieminen, Pentti; Myllynen, Päivi; Meltzer, Helle Margrete; Vähäkangas, Kirsi; Rautio, Arja

doi:10.1016/j.envint.2018.02.028

Cited by 26 publications

(14 citation statements)

References 63 publications

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“…Concerning human exposure to mercury, it is primarily associated particularly with the consumption of contaminated fish and other seafood that turns MeHg the most toxic form of this metal [8]. Additionally, it is important to consider that levels of mercury in the blood also have a positive correlation with the number of dental restorations [9], the total surface of amalgam, and organic mercury concentration in the saliva [10].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Nogueira

Vasconcelos

Mitre

et al. 2019

Oxidative Medicine and Cellular Longevity

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Human exposure to mercury (Hg) is primary associated with its organic form, methylmercury (MeHg), through the ingestion of contaminated seafood. However, Hg contamination is also positively correlated with the number of dental restorations, total surface of amalgam, and organic mercury concentration in the saliva. Among the cells existing in the oral cavity, human periodontal ligament fibroblast (hPLF) cells are important cells responsible for the production of matrix and extracellular collagen, besides sustentation, renewal, repair, and tissue regeneration. In this way, the present study is aimed at investigating the potential oxidative effects caused by MeHg on hPLF. Firstly, we analyzed the cytotoxic effects of MeHg (general metabolism status, cell viability, and mercury accumulation) followed by the parameters related to oxidative stress (total antioxidant capacity, GSH levels, and DNA damage). Our results demonstrated that MeHg toxicity increased in accordance with the rise of MeHg concentration in the exposure solutions (1-7 μM) causing 100% of cell death at 7 μM MeHg exposure. The general metabolism status was firstly affected by 2 μM MeHg exposure (43.8 ± 1.7%), while a significant decrease of cell viability has arisen significantly only at 3 μM MeHg exposure (68.7 ± 1.4%). The ratio among these two analyses (named fold change) demonstrated viable hPLF with compromised cellular machinery along with the range of MeHg exposure. Subsequently, two distinct MeHg concentrations (0.3 and 3 μM) were chosen based on LC50 value (4.2 μM). hPLF exposed to these two MeHg concentrations showed an intracellular Hg accumulation as a linear-type saturation curve indicating that metal accumulated diffusively in the cells, typical for metal organic forms such as methyl. The levels of total GSH decreased 50% at exposure to 3 μM MeHg when compared to control. Finally, no alteration in the DNA integrity was observed at 0.3 μM MeHg exposure, but 3 μM MeHg caused significant damage. In conclusion, it was observed that MeHg exposure affected the general metabolism status of hPLF with no necessary decrease on the cell death. Additionally, although the oxidative imbalance in the hPLF was confirmed only at 3 μM MeHg through the increase of total GSH level and DNA damage, the lower concentration of MeHg used (0.3 μM) requires attention since the intracellular mercury accumulation may be toxic at chronic exposures.

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Section: Introductionmentioning

confidence: 99%

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Nogueira

Vasconcelos

Mitre

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Studies on the precise impact of environmental pollutants on human health in the Arctic are difficult to undertake and interpret because many factors influence health at the same time and to varying degrees. These include both genetic and environmental factors [31,32].…”

Section: An Example From Life Science: Risks To Human Health and Wellbeingmentioning

confidence: 99%

“…Environmental factors and the impact of warming climate and permafrost thaw will affect the volatilization and distribution of persistent organic pollutants (POPs) and heavy metals [32,33] and also increase risk of zoonotic diseases in the Arctic regions [34,35]. Many permanent organic contaminants (e.g., PCBs) and heavy metals (e.g., mercury) have declining trends in human biological matrices and biota, but the recent results of modelling and measurements showed an increase in environmental concentrations in a warmer climate [31,32]. Climate change is altering disease-vector populations, ranges, and life cycles, and together with simultaneous increased human activities, such as tourism and shipping, there are additional risks for spreading of new species (e.g., insect vectors), pathogens, and pollution among Arctic wildlife and humans [34].…”

Section: An Example From Life Science: Risks To Human Health and Wellbeingmentioning

confidence: 99%

“…Quantitative risk estimates by toxicokinetic modelling are a way of estimating hazard quotient (HQ) for noncancer effects and the excess lifetime cancer risk (CR) based on contaminant levels in human biological matrices. A modified approach based on the traditional risk assessment process has been introduced for quantitative risk estimates [31]. This comprises three stages: extrapolation of exposure by pharmacokinetic modelling; incorporation of the reference dose and cancer slope factor; estimation of HQ and life-time cancer risk.…”

Section: Toxicokinetic Modelling and Future Risk Predictionmentioning

confidence: 99%

“…Epidemiological studies usually include several exposure variables and health related outcomes. Several epidemiological studies were established in the circumpolar area to examine the relationship between exposure to contaminants and health outcomes [31]. Epidemiological studies usually overcome the limitation of traditional risk assessment approaches, including the single contaminant-based assessment in the common multicontaminants context, the interaction between chemical and nonchemical stressors as well as the reliance on uncertainty factors and assumptions [41].…”

Section: Toxicokinetic Modelling and Future Risk Predictionmentioning

confidence: 99%

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Thawing Permafrost in Arctic Coastal Communities: A Framework for Studying Risks from Climate Change

et al. 2021

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Thawing permafrost creates risks to the environment, economy and culture in Arctic coastal communities. Identification of these risks and the inclusion of the societal context and the relevant stakeholder involvement is crucial in risk management and for future sustainability, yet the dual dimensions of risk and risk perception is often ignored in conceptual risk frameworks. In this paper we present a risk framework for Arctic coastal communities. Our framework builds on the notion of the dual dimensions of risk, as both physically and socially constructed, and it places risk perception and the coproduction of risk management with local stakeholders as central components into the model. Central to our framework is the importance of multidisciplinary collaboration. A conceptual model and processual framework with a description of successive steps is developed to facilitate the identification of risks of thawing permafrost in a collaboration between local communities and scientists. Our conceptual framework motivates coproduction of risk management with locals in the identification of these risks from permafrost thaw and the development of adaptation and mitigation strategies.

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The Causes and Effects of Mercury and Methylmercury Contamination in the Marine Environment: A Review

Al-Sulaiti

Soubra

2022

Curr Pollution Rep

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Purpose of Review The concern of mercury pollution and the impact that it poses on the marine environment were studied heavily since the case of the poison from Minamata bay in the 1960s. The present study provides an insight into the cycle of mercury and methylmercury in the marine environment and the bioindicators that reflect the exposure levels. The paper also used the driving forces, pressures, states, impacts, and responses (DPSIR) analysis to evaluate the global mercury and methylmercury contamination problem. Recent Findings The high global budgets of atmospheric total mercury influence the ocean surface water. Therefore, the aquatic environment contamination level is in turn affected by the surrounding emission sources such as industrial and petroleum activities in addition to the transport and fate of mercury across the environmental compartments. This will increase the mercury levels in fish species and will cause an adverse risk to human health through biomagnification. Summary This review presents a thorough description of mercury sources and emissions and their fate and transport across the different environmental compartments, despite the fact that serious mitigation measures were taken and guidelines were applied. The risk from fish consumption is still a serious concern as a result of the current mercury emissions and stability and persistent characteristics.

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Quantitative estimation of mercury intake by toxicokinetic modelling based on total mercury levels in humans

Cited by 26 publications

References 63 publications

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Thawing Permafrost in Arctic Coastal Communities: A Framework for Studying Risks from Climate Change

The Causes and Effects of Mercury and Methylmercury Contamination in the Marine Environment: A Review

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