Quantitative morphometric determination of arteriolar and capillary perfusion within ischemic rabbit left ventricle

Rosolowsky, Mark; Weiss, Harvey R.

doi:10.1016/0026-2862(86)90046-4

Cited by 9 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results coincide with data showing that, under similar clinical and experimental conditions, 25-30% of capillaries are incapable of perfusion (Rosolowsky and Weiss, 1986). The main cause of deterioration of MV perfusion characteristics in myo cardium protected with hypothermic ACs is inade quate rearrangement of cell membrane metabolism.…”

Section: Discussionsupporting

confidence: 89%

Ultrastructure of coronary microvessels during heart reperfusion after prolonged ischemia under conditions of various forms of artificial hypothermia

et al. 2012

View full text Add to dashboard Cite

It has been found that, in children with Roger's disease corrected under conditions of two funda mentally different procedures of anesthetic management, myocardial reperfusion after cardiac arrest under artificial hypothermic circulation is accompanied with obstruction of more than 70% of coronary bed microvessels, one third of them being blocked with hydropic endothelial cells or their cystiform fragments. It hampers or even totally prevents their functioning in the postoperative period. The content of necrotic cells increases, while the three "working" cell types demonstrate a decrease in myocropinocytotic transport. Cir culatory arrest during perfusionless hypothermia and immersion reperfusion do not result in a dramatic change of general morphology of microvessels as compared to the control group maintaining the endothelial cell population unaltered. Ultrastructural organization of endothelial microvessels displayed no features of intracellular regeneration. However, a heterogenic response of the structures responsible for transendothelial transfer of macromolecules provides the basis for the recovery of endothelium structure and function, as a patient's temperature reaches the standard value.

show abstract

Section: Discussionsupporting

confidence: 89%

Ultrastructure of coronary microvessels during heart reperfusion after prolonged ischemia under conditions of various forms of artificial hypothermia

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Rosolowsky and Weiss (1986) found no significant changes of capillary diameter between regions of occluded (60 min) and nonoccluded myocardium of rabbits. Pawlik et ai.…”

Section: Methodological Issuesmentioning

confidence: 63%

Reduction of Functional Capillary Density in Human Brain after Stroke

Gjedde

Kuwabara

Hakim

1990

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary:The blood flow of brain tissue often returns to normal after an ischemic episode. As "luxury" rather than "reactive" reperfusion, this hyperemia is associated with low metabolism. It is not known to what extent the high blood flow accompanies a high, normal, or low den sity of capillaries. The resolution of this question may indicate whether the functional capillary density is vari able and, if so, whether it is coupled to blood flow or metabolism. To answer these questions, we defined func tional capillaries as capillaries that transport glucose. We then calculated the density of functional capillaries (D cap) and the mean time of transit of blood through the capil laries (tca p) from hemodynamic variables obtained in vivo by positron tomography of five patients afflicted by cere bral ischemic stroke. Each patient was studied twice, within 36 h of the insult and 1 week later. We identified nominally "ischemic" regions in the first study as cortical gray matter regions, contiguous with the ischemic focus,The density of capillaries varies between the re gions of the brain (Craigie, 1945). The variation ap pears to have a cytoarchitectural basis, suggesting that the total number of capillaries in any region is a reflection of the normal average energy require ment of that region. However, evidence from other organs in animal experiments suggests that not all capillaries in a brain region function equally well as

show abstract

“…Significant alteration of microvascular diameter does not occur in the myocardium after 1 hour of ischemia, 33 although capillary dilatation is known to occur 24 hours after ischemia/reperfusion in the MCA territory. 34 The absence of bias or shift to larger diameter in the normalized distribution of the ischemic territory in the present experiments argues strongly against a significant contribution of vascular enlargement.…”

mentioning

confidence: 95%

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

Mori

Zoppo

Chambers

et al. 1992

Stroke

341

177

View full text Add to dashboard Cite

Background and Purpose: While polymorphonuclear leukocytes may contribute to the "no-reflow" phenomenon after focal cardiac and skeletal muscle ischemia/reperfusion, their contribution to acute focal cerebral ischemia is unresolved. We have examined the role of polymorphonuclear leukocytes in microvascular perfusion defects after focal cerebral ischemia/reperfusion in a baboon model of reversible middle cerebral artery occlusion with the anti-CD18 monoclonal antibody IB4, which inhibits neutrophil adherence to endothelium.Methods: Microvascular patency in the basal ganglia after 3-hour middle cerebral artery occlusion and 1-hour reperfusion (by india ink tracer perfusion) was quantified by computerized video imaging. Animals were randomized to receive intravenous IB4 infusion 15 minutes before reperfusion (n=7) or to receive no treatment (n=6). Binding of IB4 to baboon leukocytes was maximal within 5 minutes of infusion.Results: In the untreated group, a significant reduction in patency was observed in mlcrovessels <30 /un diameter mean percent reflow was 51% in the capillary diameter class (4.0-7 J /tm) and 39% in the precapillary arteriole and postcapillary venule diameter class (7-5-30 /im). Infusion ofIB4 before middle cerebral artery reperfusion increased reflow in microvessels of all size classes, most significantly in those 7.5-30 /tm (p=0.049) and 30-50 pm (p=0.034) in diameter.Conclusions: These results suggest that CD18-mediated polymorphonuclear leukocyte-endothelium adherence contributes to no-reflow predominantly in noncapillary microvessels and at least partially to that in capillaries. (Stroke 1992^3:712-718) KEY WORDS • antibodies, monoclonal • cerebral ischemia • microcirculation • neutrophils • baboons

show abstract

Quantitative morphometric determination of arteriolar and capillary perfusion within ischemic rabbit left ventricle

Cited by 9 publications

References 27 publications

Ultrastructure of coronary microvessels during heart reperfusion after prolonged ischemia under conditions of various forms of artificial hypothermia

Ultrastructure of coronary microvessels during heart reperfusion after prolonged ischemia under conditions of various forms of artificial hypothermia

Reduction of Functional Capillary Density in Human Brain after Stroke

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

Contact Info

Product

Resources

About