Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry

Development and validation of a streamlined method designed to detect residues of 62 veterinary drugs in bovine kidney using ultra‐high performance liquid chromatography – tandem mass spectrometry

“…[20][21][22][23][24] The MMM of Kaufmann et al [25] was also performed, but it was deemed to be too laborious and time-consuming for our purposes. Each method had advantages in some respect over the others.…”

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

“…MeOH and EtOAc are also widely used solvents but result in the extraction of additional matrix components [15]. However, in the area of multiresidue analysis there is always a compromise between recovery and the purity of sample extracts.…”

“…ACN is the preferred extraction solvent as it gives good yields of residues but low levels of matrix co-extractives and is effective at denaturing proteins and inactivating enzymes [15]. MeOH and EtOAc are also widely used solvents but result in the extraction of additional matrix components [15].…”

“…A disadvantage is that strongly protein-bound residues are not fully extracted and polar matrix components are co-extracted. In general, the majority of methods employ more efficient organic solvents as extracting agents [15].…”

“…While in the past, methods were only capable of analysing lower numbers of residues (usually a single class of drug) [7-1 1], mass spectrometry now offers the possibility to analyse vast numbers of residues in a single run [12][13][14][15]. As a result, there is now a tendency to focus towards more generic extraction and clean-up procedures to cover the wide range of veterinary drugs that can be found in food of animal origin [15][16][17].…”