Quantitative <scp>MRI</scp> Studies of Chronic Brain White Matter Hyperintensities in Migraine Patients

Aradi, Mihály; Schwarcz, Attila; Perlaki, Gábor; Orsi, G.; Kovács, Norbert; Trauninger, Anita; Kamson, David Olayinka; Erdélyi-Bótor, Szilvia; Nagy, Ferenc; Nagy, Szilvia Anett; Dóczi, Tamás; Komoly, Sámuel; Pfund, Zoltán

doi:10.1111/head.12013

Cited by 40 publications

(31 citation statements)

References 47 publications

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“…If the nature of WMHs is ischemic, different types of vascular mechanisms and differences in the degree of tissue damage may explain these processes. In our previous and present study, the 1 H‐MRS measurements presented axonal damage with mitochondrial impairment within the hyperintensity. In the animal model of multiple sclerosis, spontaneously reversible inflammatory axon damage with intra‐axonal mitochondrium pathology was discovered .…”

Section: Discussionsupporting

confidence: 69%

Changes of Migraine‐Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study

et al. 2014

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Section: Discussionsupporting

confidence: 69%

Changes of Migraine‐Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study

et al. 2014

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“…Our findings are particularly interesting in this population, 23,24 since thalamocortical network dysfunction, 25,26 thalamic microstructural changes, 27,28 and thalamic morphological abnormalities 29 have been recently demonstrated in individuals with migraine. Migraine is a disorder that is frequently clinically and radiographically mistaken for MS, 5,6 and previous studies have also suggested an increased risk of migraine in patients with MS. 30 In our MS + c cohort, 6/10 participants had migraine.…”

Section: Discussionmentioning

confidence: 63%

MRI evaluation of thalamic volume differentiates MS from common mimics

Solomon

Watts

Reich

2017

Neurol Neuroimmunol Neuroinflamm

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Objective:To determine whether MRI evaluation of thalamic volume differentiates MS from other disorders that cause MRI white matter abnormalities.Methods:There were 40 study participants: 10 participants with MS without additional comorbidities for white matter abnormalities (MS − c); 10 participants with MS with additional comorbidities for white matter abnormalities (MS + c); 10 participants with migraine, MRI white matter abnormalities, and no additional comorbidities for white matter abnormalities (Mig − c); and 10 participants previously incorrectly diagnosed with MS (Misdx). T1-magnetization-prepared rapid gradient-echo and T2-weighted three-dimensional fluid attenuation inversion recovery sequences were acquired on a Phillips Achieva d-Stream 3T MRI, and scans were randomly ordered and de-identified for a blinded reviewer who performed MRI segmentation using LesionTOADS.Results:Mean normalized thalamic volume differed among the 4 cohorts (analysis of variance, p = 0.005) and was smaller in the 20 MS participants compared with the 20 non-MS participants (p < 0.001), smaller in MS − c compared with Mig − c (p = 0.03), and smaller in MS + c compared with Misdx (p = 0.006). The sensitivity and specificity were both 0.75 for diagnosis of MS with a thalamic volume <0.0077.Conclusions:MRI volumetric evaluation of the thalamus, but not other deep gray-matter structures, differentiated MS from other diseases that cause white matter abnormalities and are often mistaken for MS. Evaluation for thalamic atrophy may improve accuracy for diagnosis of MS as an adjunct to additional radiologic criteria. Thalamic volumetric assessment by MRI in larger cohorts of patients undergoing evaluation for MS is needed, along with the development of automated and easily applied volumetric assessment tools for future clinical application.Classification of evidence:This study provides Class III evidence that MRI evaluation of thalamic volume differentiates MS from other diseases that cause white matter abnormalities.

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“…White matter lesions were detected more often in migraine patients than healthy controls [17,18] and found to be associated with frequency of attacks, age and family history of migraine [18] as well as disease duration [19,20]. Microvascular ischemic disturbances are suggested as a cause for alterations of white matter microstructure [21].…”

Section: White Matter Abnormalities In Migrainementioning

confidence: 98%

Microstructural and network abnormalities in headache

Ellerbrock¹,

Engel

May³

2013

Current Opinion in Neurology

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Owing to novel neuroimaging approaches and evaluation methods, a range of possibilities for exploring brain differences between migraine patients and healthy subjects have become available. These include both regional structural alterations and network connectivity changes. Despite methodological advances, most studies involve still small populations and results are often inconclusive. Future work should clearly involve larger cohorts and combine different techniques to help us better understand the diagnostic implications.

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Quantitative MRI Studies of Chronic Brain White Matter Hyperintensities in Migraine Patients

Abstract: The MRI measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks.

Cited by 40 publications

References 47 publications

Changes of Migraine‐Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study

Changes of Migraine‐Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study

MRI evaluation of thalamic volume differentiates MS from common mimics

Microstructural and network abnormalities in headache

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