Quantitative self-powered electrochromic biosensors

Pellitero, Miguel Aller; Guimerà‐Brunet, Anton; Κιτσαρά, Μαρία; Villa, Rosa; Rubio, Camille; Lakard, Boris; Doche, Marie‐Laure; Hihn, Jean‐Yves; Campo, F. Javier del

doi:10.1039/c6sc04469g

Cited by 66 publications

(37 citation statements)

References 35 publications

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“…The self-powered glucose biosensors mentioned by Katz et al, Valdés-Ramírez et al, and Cheng et al are fundamentally different as it is a self-powered biosensor based on the correlation of changes in peak power density or voltage drop across a load with glucose concentration whereas here we demonstrated a self-powered biosensor employing an enzymatic glucose biofuel cell with a charge pump circuit and a capacitor to transduce the biochemical reaction occurring at the bioelectrodes [31][32][33]. To the extent of our knowledge, the system mentioned in Pellitero et al [34] describes a self-powered electrochromic biosensor that employs a potentiostatic system for interrogating the bioanode under constant polarization at 0.2 V vs. Ag/AgCl to achieve a dynamic range up 20 mM. The system we demonstrated is an improvement on these existing systems because it eliminates the use of variable resistive load, while enabling fast detection of glucose by monitoring the charge/discharge frequency of the transducer.…”

Section: Resultsmentioning

confidence: 71%

Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Slaughter

Kulkarni

2019

Energies

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This work presents the characterization of a self-powered glucose biosensor using individual sequential assays of human plasma glucose obtained from diabetic patients. The self-powered glucose biosensor is exploited to optimize the assay parameters for sensing plasma glucose levels. In particular, the biofuel cell component of the system at pH 7.4, 37 °C generates a power density directly proportional to plasma glucose and exhibited a maximum power density of 0.462 mW·cm−2 at a cell voltage of 0.213 V in 5 mM plasma glucose. Plasma glucose is further sensed by monitoring the charge/discharge frequency (Hz) of the integrated capacitor functioning as the transducer. With this method, the plasma glucose is quantitatively detected in 100 microliters of human plasma with unprecedented sensitivity, as high as 104.51 ± 0.7 Hz·mM−1·cm−2 and a detection limit of 2.31 ± 0.3 mM. The results suggest the possibility to sense human plasma glucose at clinically relevant concentrations without the use of an external power source.

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Section: Resultsmentioning

confidence: 71%

Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Slaughter

Kulkarni

2019

Energies

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“…This method has been widely used for the construction of printed and patterned conjugated polymers for solar cells and light‐emitting diodes . In line with previous reports , we propose the use of carrier conductive metal oxide particles dispersed in a resin binder, with the novelty of incorporating the ECP‐Magenta polymer as the electrochromic coating. We have investigated the use of antimony‐doped tin oxide microparticles (ATO/TiO 2 ) as a conducting light‐coloured material for use in spectroelectrochemistry .…”

Section: Introductionmentioning

confidence: 99%

Screen‐printable Electrochromic Polymer Inks and Ion Gel Electrolytes for the Design of Low‐power, Flexible Electrochromic Devices

et al. 2019

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We have developed electrochromic inks and electrolyte materials to enable mass production of flexible electrochromic displays (ECDs) and other optoelectronic devices by screen printing. Here we present a new screen‐printable ink incorporating electrochromic polymer, poly(3,4‐propylenedioxythiophene)bis(ethylhexyloxy), referred to here as ECP‐Magenta, and antimony‐doped tin oxide (ATO/TiO2) particles to facilitate electron transport. Their dispersion in a P(VDF‐co‐HFP) binder leads to the formation of a new electrochromic ink that is suitable for screen printing. This strategy opens the door to the preparation of similar electrochromic inks based on other organic or polymeric compounds. This approach is scalable and can applied to different fields. Ion gels (IGs) composed of P(VDF‐co‐HFP) and room temperature ionic liquids (RTILs) are promising solid‐state electrolytes with high ionic conductivity, flexibility, elasticity and eco‐friendliness. The electrochemical features of different ion gels were analyzed as a function of composition and nature of the ionic liquid. Hence, new formulations of IGs were developed, evaluated by Electrochemical Impedance Spectroscopy, Cyclic Voltammetry, before being incorporated into ECDs. The electrochromic performance of ECP‐Magenta ink combined with the RTIL‐based IG was evaluated by terms of spectroelectrochemistry showing that fully flexible ECD operating at voltages below 1 V can be screen‐printed.

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“…One is to reduce the overall number of silicon components to a single chip, and with as few contact pads as possible. The other solution involves devices that do not require silicon or any kind of discrete components at all [65]. This second approach may have been completely unfeasible only a few years ago, but progress in printed electronics may soon enough make it possible [66][67][68].…”

Section: Design and Fabrication Of Wearable Devicesmentioning

confidence: 99%

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

et al. 2019

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Smart wearables, among immediate future IoT devices, are creating a huge and fast growing market that will encompass all of the next decade by merging the user with the Cloud in a easy and natural way. Biological fluids, such as sweat, tears, saliva and urine offer the possibility to access molecular-level dynamics of the body in a non-invasive way and in real time, disclosing a wide range of applications: from sports tracking to military enhancement, from healthcare to safety at work, from body hacking to augmented social interactions. The term Internet of Wearables (IoW) is coined here to describe IoT devices composed by flexible smart transducers conformed around the human body and able to communicate wirelessly. In addition the biochemical transducer, an IoW-ready sensor must include a paired electronic interface, which should implement specific stimulation/acquisition cycles while being extremely compact and drain power in the microwatts range. Development of an effective readout interface is a key element for the success of an IoW device and application. This review focuses on the latest efforts in the field of Complementary Metal–Oxide–Semiconductor (CMOS) interfaces for electrochemical sensors, and analyses them under the light of the challenges of the IoW: cost, portability, integrability and connectivity.

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Quantitative self-powered electrochromic biosensors

Abstract: Electrochromic materials can be used in self-powered electrochemical sensors to display quantitative information without the need for silicon-based electronics or external instrumentation.

Cited by 66 publications

References 35 publications

Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Screen‐printable Electrochromic Polymer Inks and Ion Gel Electrolytes for the Design of Low‐power, Flexible Electrochromic Devices

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

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