The influence of the anisotropic disorder on quantum interference was studied in the intentionally disordered GaAs/Al x Ga 1Ϫx As superlattices. In the case of sufficiently strong disorder the quantum interference exhibited a structural dependence resulting in the anisotropy of the phase-breaking time, which was found shorter in the direction of the disorder. The anisotropy effects were shown stronger in the insulating transport regime than in the metallic one. The weak-localization negative magnetoresistance was used to obtain the vertical coupling constant in the disordered superlattices.