Quasi-block copolymer design of quaternized derivatives of poly(2-(dimethylamino)ethyl methacrylate): Investigations on thermo-induced self-assembly

Lechuga‐Islas, Víctor D.; Festag, Grit; Rosales‐Guzmán, Miguel; Vega-Becerra, O.; Guerrero‐Santos, Ramiro; Schubert, Ulrich S.; Guerrero‐Sánchez, Carlos

doi:10.1016/j.eurpolymj.2019.109457

Cited by 15 publications

(9 citation statements)

References 70 publications

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“…Diblock and triblock copolymers containing hydrophilic polyacrylic acid and hydrophobic poly(acrylic acid‐ ran ‐butyl acrylate) [22–24] or poly(acrylic acid‐ ran ‐styrene) [25–27] segments show reversible associations across a wide pH range. Copolymers with more complex composition profiles, incorporating hydrophilic homopolymer and moderately hydrophobic gradient copolymer segments may also undergo reversible self‐assembly in response to changes in temperature [28–30] or pH [8, 29] . These results indicate that the incorporation of hydrophilic groups into the hydrophobic segment of an amphiphilic copolymer can have a significant effect on its self‐assembly behavior.…”

Section: Introductionmentioning

confidence: 94%

“…[5,[9][10][11]15] More recently,a mphiphilic copolymers containing mixed segments (e.g.g radient copolymers and block copolymers with hydrophilic monomers incorporated into the hydrophobic segment) have been shown to form self-assemblies that respond dynamically to changes in their environment. [17,18] Gradient copolymer assemblies may exhibit reversible changes in size [7,19,20] or shape [20,21] in response to changes in solvent quality.D iblock and triblock copolymers containing hydrophilic polyacrylic acid and hydrophobic poly(acrylic acid-ran-butyl acrylate) [22][23][24] or poly(acrylic acid-ran-styrene) [25][26][27] segments show reversible associations across awide pH range.C opolymers with more complex composition profiles,incorporating hydrophilic homopolymer and moderately hydrophobic gradient copolymer segments may also undergo reversible self-assembly in response to changes in temperature [28][29][30] or pH. [8,29] These results indicate that the incorporation of hydrophilic groups into the hydrophobic segment of an amphiphilic copolymer can have as ignificant effect on its self-assembly behavior.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hydrophilic Monomer Distribution on Self‐Assembly of a pH‐Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

et al. 2020

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A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA‐BA diblock copolymer to a linear gradient poly(AA‐grad‐BA) copolymer were synthesized and their pH‐responsive self‐assembly behavior was investigated. While assemblies of the AA‐BA diblock copolymer were kinetically frozen, the gradient‐like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo‐transmission electron microscopy and small angle neutron scattering.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effect of Hydrophilic Monomer Distribution on Self‐Assembly of a pH‐Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

et al. 2020

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“…Since the earliest application of DMAEMA as a drug carrier in 1987 by Sefton and his coworkers [13], a wide range of polymers with various chemical structures and properties have been produced, investigated, and analyzed in drug delivery systems. Because of its unique ionic strength and chemical functionalization, DMAEMA is a thoroughly researched polymer [14,15]. Besides, it is non-toxic, water-soluble [16], biocompatible [17], charged macromolecule [18], possesses extraordinary pH responsiveness in acidic environments and is non-toxic to live creatures [19].…”

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confidence: 99%

Nanogels obtained by gamma radiation induced polymerization

Shafie

Hamzah

Ali

2021

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The influence of 2-(dimethylamino)ethyl methacrylate (DMAEMA) concentration on the temperature sensitivity of nanogels based on N-isopropylacrylamide (NIPAAM), poly(vinylpyrrolidone) (PVP), poly(ethylene glycol) diacrylate (PEGDA) by gamma radiation induced polymerization was investigated. Dynamic light scattering (DLS) and zeta potential measurements were used to characterize the nanogels. Temperature has been found to cause the nanogel particles to swell and shirnkage, allowing controlled dosing of the drug contained in capsules. The developed nanogels are promising materials with great potential for biomedical applications.

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“…The preparation of block [ 1 ], spontaneous gradient [ 2 ], gradient or asymmetric [ 3 , 4 ] copolymers remains in the spotlight due to the intrinsic self-assembly properties of these macromolecules. Furthermore, the synthesis of functional polymers is an additional area of interest due to the numerous possibilities that arise from adding and transforming molecules with different functionalities by exploring different synthetic pathways.…”

Section: Introductionmentioning

confidence: 99%

Triazole-Functionalized Mesoporous Materials Based on Poly(styrene-block-lactic acid): A Morphology Study of Thin Films

et al. 2022

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We report the synthesis of poly(styrene-block-lactic acid) (PS-b-PLA) copolymers with triazole rings as a junction between blocks. These materials were prepared via a ‘click’ strategy which involved the reaction between azide-terminated poly(styrene) (PS-N3) and acetylene-terminated poly(D,L-lactic acid) (PLA-Ac), accomplished by copper-catalyzed azide-alkyne cycloaddition reaction. This synthetic approach has demonstrated to be effective to obtain specific copolymer structures with targeted self-assembly properties. We observed the self-assembly behavior of the PS-b-PLA thin films as induced by solvent vapor annealing (SVA), thermal annealing (TA), and hydrolysis of the as-spun substrates and monitored their morphological changes by means of different microscopic techniques. Self-assembly via SVA and TA proved to be strongly dependent on the pretreatment of the substrates. Microphase segregation of the untreated films yielded a pore size of 125 nm after a 45-min SVA. After selectively removing the PLA microdomains, the as-spun substrates exhibited the formation of pores on the surface, which can be a good alternative to form an ordered pattern of triazole functionalized porous PS at the mesoscale. Finally, as revealed by scanning electron microscopy–energy dispersive X-ray spectroscopy, the obtained triazole-functionalized PS-porous film exhibited some affinity to copper (Cu) in solution. These materials are suitable candidates to further study its metal-caption properties.

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Quasi-block copolymer design of quaternized derivatives of poly(2-(dimethylamino)ethyl methacrylate): Investigations on thermo-induced self-assembly

Cited by 15 publications

References 70 publications

Effect of Hydrophilic Monomer Distribution on Self‐Assembly of a pH‐Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

Effect of Hydrophilic Monomer Distribution on Self‐Assembly of a pH‐Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

Nanogels obtained by gamma radiation induced polymerization

Triazole-Functionalized Mesoporous Materials Based on Poly(styrene-block-lactic acid): A Morphology Study of Thin Films

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