Quasi-direct numerical simulation of lift force-induced particle separation in a curved microchannel by use of a macroscopic particle model

Agrawal, Monika; Street, David; Ogawa, Kohei

doi:10.1016/j.ces.2007.01.031

Cited by 20 publications

(10 citation statements)

References 9 publications

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“…As mentioned, the overall velocity fields rotate in a counterclockwise direction to the x axis. In the commercial CFD codes, the particle trajectory is predicted without considering the steric effect in the grooved microchannel 18. Therefore, they are not appropriate for the modeling of hydrophoretic particle ordering.…”

Section: Resultsmentioning

confidence: 99%

Optically Coated Mirror‐Embedded Microchannel to Measure Hydrophoretic Particle Ordering in Three Dimensions

Choi

Park

2009

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Three-dimensional (3D) measurement of the behavior of microfluidic particles is vital for improving their operational efficiency and characterization. In particular, it is important to measure particle motions in 3D for exact characterization of hydrophoresis, which utilizes 3D convective flows for size separation. Herein, the 3D measurement of hydrophoretic particle ordering for the exact characterization of hydrophoresis by using an optically coated mirror-embedded microchannel is reported. The mirror, ideally at 45 degrees , reflects the side view of the channel and enables 3D positional information to be obtained easily from two different orthogonal-axis images. With this method, it is shown that hydrophoresis is governed by convective vortices and steric hindrance. It is also observed that hydrophoresis enables 3D particle focusing without sheath flows and accurate flow-rate control. The mechanism of hydrophoresis is finally verified by conducting a computational simulation and comparing the simulation results with the experimental measurements. The hydrophoretic method can be straightforwardly integrated as a 3D particle-focusing component in integrated microfluidic systems. The mirror-embedded channel can also be readily fabricated in a single cast of polydimethylsiloxane, thus offering low-cost, easy implementation of 3D particle measurement.

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Section: Resultsmentioning

confidence: 99%

Optically Coated Mirror‐Embedded Microchannel to Measure Hydrophoretic Particle Ordering in Three Dimensions

Choi

Park

2009

Small

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“…Apart from this, adding curvature to the channel (such as a spiral or serpentine curve) introduces a transverse secondary flow (i.e., a Dean flow). The Dean flow is composed of two counter-rotating vortices (Dean vortices) that are perpendicular to the direction of the primary channel flow; the velocity of the Dean flow varies across different parts of the channel, with nearly a zero value at the vortex core (54). As a consequence of the combined effect of the two size-dependent forces-the inertial lift force (F L ∝ a p 4 ) and the additional Dean drag force (F D ∝ a p )-particles with diverse diameters display different focusing degrees at distinct lateral positions across the width of the channel when flowing through the same curved microchannels.…”

Section: Inertial Separation (Operation At Moderate Reynolds Numbers)mentioning

confidence: 99%

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

Warkiani

Wu²,

Tay

et al. 2015

Annu. Rev. Biomed. Eng.

104

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Microfluidic cell-separation technologies have been studied for almost two decades, but the limited throughput has restricted their impact and range of application. Recent advances in microfluidics enable high-throughput cell sorting and separation, and this has led to various novel diagnostic and therapeutic applications that previously had been impossible to implement using microfluidics technologies. In this review, we focus on recent progress made in engineering large-volume microfluidic cell-sorting methods and the new applications enabled by them.

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“…From then on, much effort has been made to uncover the mechanism of this interesting phenomenon both theoretically and experimentally . A range of novel applications based on the inertial focusing has been developed, especially in micro channels with the rise of microfabrication, including particle filtration, separation, flow cytometry, and so on. However, as the particle size goes down to micron or submicron scale, agglomeration is inevitable during the transport of particle suspensions due to the cohesive nature, which in turn produces numerous negative effects in industries.…”

Section: Introductionmentioning

confidence: 99%

Migration and agglomeration of adhesive microparticle suspensions in a pressure‐driven duct flow

Liu

2020

AIChE Journal

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Transport of suspensions consisting of monodisperse adhesive microparticles in a pressuredriven duct flow with the Reynolds number in the range of 5.4-108 is analyzed by means of a coupled lattice Boltzmann method with the discrete element method. The influence of the adhesion on migration and agglomeration of particles is investigated. The results show that the suspensions undergo a transition from purely lateral focusing to completely agglomeration as the surface energy is increased. A dimensionless adhesion number, defined as the ratio of the adhesive force to the drag force, is employed to characterize the degree of agglomeration. It is found that all the particles come into agglomerates as the adhesion number reaches a critical value. Moreover, a detailed examination of size evolution and velocity illustrates that the agglomerates mainly grow spherically, and their velocities depend on the lateral positions rather than their sizes, as the Stokes number is far below one.adhesion, agglomeration, discrete element method, duct flow, lattice Boltzmann method 1 | INTRODUCTION Migration of particle suspensions in a confined channel or vessels are ubiquitous in industries and engineering, such as petroleum production, food processing, pharmaceuticals, sewage treatment, as well as microfluids in biological processes. It is first observed by Segré and Silberberg 1 that a spherical particle in a Poiseuille pipe flow migrates across the streamline and focuses at a specific equilibrium position at approximately 0.6 times the radius from the axis. From then on, much effort has been made to uncover the mechanism of this interesting phenomenon both theoretically 2-5 and experimentally. 6-11 A range of novel applications based on the inertial focusing has been developed, especially in micro channels with the rise of microfabrication, including particle filtration, separation, flow cytometry, 12-16 and so on. However, as the particle size goes down to micron or submicron scale, agglomeration is inevitable during the transport of particle suspensions due to the cohesive nature, which in turn produces numerous negative effects in industries. For example, the agglomeration of asphaltenes or gas hydrates causes pipeline blockage 17,18 in the oil and gas exploration and refining industries. Therefore, it is of great importance to gain in-depth knowledge of the agglomeration mechanism.It is generally recognized that the agglomeration is driven by the collisions of particles and the cohesive interaction. The collisions could be induced by shear flow, diffusion or Brownian motion, while the cohesive interaction may be caused by different types of forces, such as electrostatic, van der Waals, and liquid bridge. Moreover, the mechanical properties of the particles, including mass density, elastic modulus, friction coefficient, and so on also play important roles in the interparticle collision and thus can influence the agglomeration. Most of the previous studies focus on the dynamic evolution of the agglomerates, include the size evolu...

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Quasi-direct numerical simulation of lift force-induced particle separation in a curved microchannel by use of a macroscopic particle model

Cited by 20 publications

References 9 publications

Optically Coated Mirror‐Embedded Microchannel to Measure Hydrophoretic Particle Ordering in Three Dimensions

Optically Coated Mirror‐Embedded Microchannel to Measure Hydrophoretic Particle Ordering in Three Dimensions

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

Migration and agglomeration of adhesive microparticle suspensions in a pressure‐driven duct flow

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