The two Göllüdağ and Acıgöl volcanic complexes are located in Cappadocia and belong to the Central Anatolia Volcanic Province. Their activity covers a wide time range from Middle to Upper Pleistocene and the Holocene. The large amount of tephra emitted explains the regional importance of this activity; whereas, the study of obsidian associated with their activity relates to several archaeological topics and research questions. Intensive field work in and around both complexes allows to present here a detailed tephrostratigraphy. In addition, results of ~ 460 single grain geochemical analyses (about 5-10 analyses for each sample out of a total of 48 samples) as well as intensive mineral counting provide an accurate reference set of signatures of Pleistocene rhyolitic tephras in Cappadocia. Correlations are based on stratigraphic observation and characterization of the tephra layers, and are also supported by multivariate statistical analyses. Chronology, constrained by 18 radiometric data (mainly K/Ar), demonstrates the Middle Pleistocene age of the main Göllüdağ tuff (ca 1.3 Ma) and confirms the Middle to Upper Pleistocene age of the main Acıgöl tuff. Our studies, thus, produce a regional tephrostratigraphic reference, which may be used for long-distance correlation. Besides, the tephra studied and analysed also form key layers used here for geomorphologic reconstruction and dating of stratigraphic and archaeological sequences.