Bias and discrimination are an ongoing, persistent problem for LGBT Mississippians. They report experiencing discrimination, harassment, assault, and negative experiences with public official, among others. These experiences with bias and discrimination begin early on, with pervasive issues in the K-12 schooling system, and continue through college and university settings. In adult life, LGBT Mississippians experience workplace bias and discrimination, medical stigma, difficulty accessing medical care, and public bias and harassment. All of these experiences take a toll, resulting in a number of negative outcomes. These include depression, suicidal thoughts, lowered academic outcomes, lowered ability to perform at the job, and lower overall physical health. However, these experiences can be lessened and negative effects mitigated.Diversity resolutions, nondiscrimination policies, and nondiscrimination ordinances make a real and positive difference in the lives of LGBT people. They provide affirming messages, decrease the perception that anti-LGBT discrimination and bias is officially sanctioned, and provide a sense of social support. All of these factors combine to result in better outcomes for LGBT people, and for the communities in which they live.