Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1

Jing, Doudou; Wu, Wei; Chen, Xuanzuo; Xiao, Hongwei; Zhang, Zhenhao; Chen, Fengxia; Zhang, Zhicai; Liu, Jianxiang; Shao, Zengwu; Pu, Feifei

doi:10.1016/j.phrs.2022.106287

Cited by 30 publications

(30 citation statements)

References 53 publications

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“…It is reported that quercetin blocks JAK2 in a noncovalent way via the JH2 domain, which stops osteosarcoma growth and prevents immune escape through the JAK2‐STAT3‐PD‐L1 signaling axis. More significantly, quercetin is encapsulated with folic acid‐modified liposomes to overcome the drawbacks, such as limited water solubility and low oral availability (Jing et al, 2022). S. Balakrishnan developed the gold nanoparticle‐based quercetin drug delivery system (AuNPs‐Qu‐5) and used these nanoconjugates against cancer cells to increase the effectiveness of quercetin.…”

Section: Quercetin In the Treatment Of Oxidative Stress‐related Diseasesmentioning

confidence: 99%

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Zhou

Qian

Tang

et al. 2023

Phytotherapy Research

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Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity of quercetin has been extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, and reactive oxygen species (ROS). Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells. By regulating oxidative stress and inflammation, which are regarded as two critical processes involved in the defense and regular physiological operation of biological systems, quercetin has been validated to be effective in treating a variety of disorders. Symptoms of these reactions have been linked to degenerative processes and metabolic disorders, including metabolic syndrome, cardiovascular, neurodegeneration, cancer, and nonalcoholic fatty liver disease. Despite that evidence demonstrates that antioxidants are employed to prevent excessive oxidative and inflammatory processes, there are still concerns regarding the expense, accessibility, and side effects of agents. Notably, natural products, especially those derived from plants, are widely accessible, affordable, and generally safe. In this review, the antioxidant and antiinflammatory abilities of the active ingredient quercetin and its application in oxidative stress‐related disorders have been outlined in detail.

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Section: Quercetin In the Treatment Of Oxidative Stress‐related Diseasesmentioning

confidence: 99%

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Zhou

Qian

Tang

et al. 2023

Phytotherapy Research

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“…Several studies highlight the anti-oxidation, antiviral, antimicrobial, anti-inflammatory, and antitumor properties of quercetin (Davoodvandi et al, 2020;Di Petrillo et al, 2022). Li et al (2022) Expression of PD-L1 on osteosarcoma cells is dramatically decreased under quercetin treatment, and this effect is due to the inhibition of the JAK2-STAT3 signaling pathway (Jing et al, 2022). Furthermore, a syngeneic tumor model was established to reveal that quercetin combined with anti-PD-1 therapy significantly inhibited tumor growth and increased the number of infiltrated CD4 + and CD8 + lymphocyte cells (Jing et al, 2022).…”

Section: Quercetinmentioning

confidence: 99%

“…Li et al (2022) Expression of PD-L1 on osteosarcoma cells is dramatically decreased under quercetin treatment, and this effect is due to the inhibition of the JAK2-STAT3 signaling pathway (Jing et al, 2022). Furthermore, a syngeneic tumor model was established to reveal that quercetin combined with anti-PD-1 therapy significantly inhibited tumor growth and increased the number of infiltrated CD4 + and CD8 + lymphocyte cells (Jing et al, 2022). Quercetin dihydrate is found to inhibit the PD-1/ PD-L1 binding, which further stimulates T cell activation and suppresses tumor growth (Jing et al, 2021).…”

Section: Quercetinmentioning

confidence: 99%

Phytochemicals in regulating PD‐1/PD‐L1 and immune checkpoint blockade therapy

Zhang,

Yang,

Gao

et al. 2023

Phytotherapy Research

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Clinical treatment and preclinical studies have highlighted the role of immune checkpoint blockade in cancer treatment. Research has been devoted to developing immune checkpoint inhibitors in combination with other drugs to achieve better efficacy or reduce adverse effects. Phytochemicals sourced from vegetables and fruits have demonstrated antiproliferative, proapoptotic, anti‐migratory, and antiangiogenic effects against several cancers. Phytochemicals also modulate the tumor microenvironment such as T cells, regulatory T cells, and cytokines. Recently, several phytochemicals have been reported to modulate immune checkpoint proteins in in vivo or in vitro models. Phytochemicals decreased programmed cell death ligand‐1 expression and synergized programmed cell death receptor 1 (PD‐1) monoclonal antibody to suppress tumor growth. Combined administration of phytochemicals and PD‐1 monoclonal antibody enhanced the tumor growth inhibition as well as CD4+/CD8+ T‐cell infiltration. In this review, we discuss immune checkpoint molecules as potential therapeutic targets of cancers. We further assess the impact of phytochemicals including carotenoids, polyphenols, saponins, and organosulfur compounds on cancer PD‐1/programmed cell death ligand‐1 immune checkpoint molecules and document their combination effects with immune checkpoint inhibitors on various malignancies.

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“…50 The surface of liposomes can be functionalized with various moieties which are designed to target specific receptors on the cells to induce their uptake. 25,55,56 The surface of liposomes was conjugated with folic acid to activate the folic acid receptor, 57,58 antibodies or antibody fragments for recognition and uptake by cell membranes containing the corresponding antigens, [59][60][61] nucleic acid, and AS1411 aptamer showing specific binding to nucleolin. 62 Controlled release from liposomes can be achieved using components incorporated in the bilayer that respond to endogenous or exogenous stimuli.…”

Section: Vesosome Preparationmentioning

confidence: 99%

Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

Koroleva

2023

Phys. Chem. Chem. Phys.

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Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1

Cited by 30 publications

References 53 publications

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Phytochemicals in regulating PD‐1/PD‐L1 and immune checkpoint blockade therapy

Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

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