Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux

Líu, Hao; Zhou, Wenling; Guo, Ling; Zhang, Heng; Guan, Lingling; Yan, Xu; Zhai, Yuanyuan; Qiao, Yuan; Wang, Zai; Zhao, Jiang; Lyu, Kangbo; Li, Ping; Wang, Haitao; Peng, Liang

doi:10.1016/j.jnutbio.2022.109060

Cited by 9 publications

(3 citation statements)

References 58 publications

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“…The ameliorative effect of quercetin on mitochondrial function and lipid metabolism has been well established as it can restore mitochondrial membrane potential, scavenge reactive oxygen species, and stimulate AMP-activated protein kinase (AMPK) activity [42][43][44] . Also, quercetin has been attributed with the restoration of lysosomal function and autophagy ux in pancreatic β-cells through the modulation of lysosomal membrane permeability 45 .…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plant-based Biologically Active Substances and Extracts Inhibit Intestinal Autofluorescence Accumulation in Caenorhabditis elegans

Salimon,

Marusich,

Leonov

2023

Preprint

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Aging is a complex process related with the gradual diminution in cellular and physiological functions. The geroprotective effect of 10 biologically active substances (BAC – rutin, squalene, kaempferol, biohanin A, urosolic acid, chlorogenic acid, baicalin, mangiferin, quercetin and trans-cinnamic acid) and 5 crude extracts (Ginkgo biloba, Pulmonaria officinalis, Scutellaria baicalensis, Hedysarum neglectum and Panax ginseng) isolated from medicinal plants of Altai Region of Russia were evaluated for their influence on the accumulation of intestinal autofluorescence material (IAM) using Caenorhabditis elegans model. Gravid nematodes were synchronized, and then seeded in 96-well plates to develop to L4-stage. Each BAC in 200 µmol, 100 µmol, 50 µmol and 10 µmol concentrations and extracts with a tenth, hundredth and thousandth times-dilution were administered to each well in 6 replicates for each treatment group. On incubation days 1, 5, and 15, adult L4 nematodes underwent spectrofluorometric analysis to determine the effect of the BACs and extracts on IAM accumulation. It was found that quercetin, kaempferol, baicalin, mangiferin, Ginkgo biloba and Panax ginseng extracts exhibited the most profound inhibition of IAM accumulation compared to the control. Thus, they can be considered as important precursors or active ingredients for the pharmacosynthesis of geroprotective drugs in future research.

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Section: Discussionmentioning

confidence: 99%

Medicinal Plant-based Biologically Active Substances and Extracts Inhibit Intestinal Autofluorescence Accumulation in Caenorhabditis elegans

Salimon,

Marusich,

Leonov

2023

Preprint

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“…For example, kaempferol, a natural flavonoid, exhibited a protective effect for β cells by activating autophagy via the AMPK/mTOR pathway in a T2D model with high palmitic acid administered [ 107 ]. Another natural flavonoid, quercetin, reduced palmitate-induced β cell apoptosis by restoring lysosomal function and autophagic flux [ 108 ]. In addition, it has been shown that omega-3 and vitamin D administration decreases the incidence of T1D in mice treated with streptozotocin (STZ) and protects β cells against STZ-induced apoptosis through upregulation of Atg7 [ 109 , 110 , 111 ].…”

Section: Modulators Of Autophagy In β Cellsmentioning

confidence: 99%

β Cell and Autophagy: What Do We Know?

et al. 2023

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Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.

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“…[37][38][39][40] In particular, research on the effects of flavonoids on β-cells has been actively conducted worldwide, and the anti-diabetic effects of various flavonoids contained in foods, such as quercetin and genistein, on β-cell function have been reported. 41,42) We have also focused on and have investigated the effects of flavonoids found in natural products such as green tea leaves and citrus peel on β-cells. In green tea, eight types of tea catechins classified due to their structure are present, and their intake has health benefits, such as reduction of blood glucose levels.…”

Section: Potential Of Natural Products In Suppressing β-Cell Apoptosismentioning

confidence: 99%

Development of Therapeutic Agents with a Novel Mechanism of Action Targeting Pancreatic β-Cells for Diabetes

Kaneko

2023

Biological & Pharmaceutical Bulletin

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Although diabetes is associated with an increased risk of various diseases, including cancer and infectious diseases, no definitive cure has yet been found. Long-term treatment for blood glucose control significantly reduces the QOL. Pancreatic β-cells are the only cells that can lower blood glucose levels by secreting insulin. Therefore, maintaining insulin-secreting β-cells is crucial in preventing the progression of diabetes and improving the QOL. We have investigated the mechanisms for the regulation of insulin secretion, the prevention of β-cell apoptosis, and the increase in β-cell mass. In particular, we have elucidated the involvement of type I diacylglycerol kinase (DGK) in the regulation of insulin secretion and the effects of nitric oxide (NO) signaling and natural products in suppressing β-cell death. In addition, we have elucidated the function of DGKδ as a suppressor of β-cell proliferation. This review introduces the findings of our study leading to development of novel anti-diabetic therapeutics that targets pancreatic β-cells.

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Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux

Cited by 9 publications

References 58 publications

Medicinal Plant-based Biologically Active Substances and Extracts Inhibit Intestinal Autofluorescence Accumulation in Caenorhabditis elegans

Medicinal Plant-based Biologically Active Substances and Extracts Inhibit Intestinal Autofluorescence Accumulation in Caenorhabditis elegans

β Cell and Autophagy: What Do We Know?

Development of Therapeutic Agents with a Novel Mechanism of Action Targeting Pancreatic β-Cells for Diabetes

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