Quercetin Protects Cutaneous Tissue-Associated Cell Types Including Sensory Neurons From Oxidative Stress Induced By Glutathione Depletion: Cooperative Effects of Ascorbic Acid

Skaper, Stephen D.; Fabris, Michele; Ferrari, V.; Carbonare, Maurizio Dalle; Leon, Alberta

doi:10.1016/s0891-5849(96)00383-8

Cited by 165 publications

(82 citation statements)

References 65 publications

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“…Phenolic compounds protect plants from oxidative damage and perform the same function for humans 15,16 . Several types of polyphenols (phenolic acids, hydrolysable tannins and flavonoids) show anti carcinogenic and anti mutagenic effects 17,18 . Flavonoids are considered to be very beneficial compounds due to their potent nature as antioxidants.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Bhandarkar¹,

Bhat²,

Vinodraj³

et al. 2015

Int. Res. J. Pharm.

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Spondias mombin is valued ethno medically in folkloric medicine. This medicinal plant according to traditional claim is said to cure various infectious and inflammatory ailments of gastrointestinal and genitourinary tract. Formation of reactive oxygen species (ROS) in inflammatory conditions is said to result in oxidative stress. The antibacterial and anti-inflammatory properties of Spondias mombin especially its leaves, have been linked to a range of compounds in it viz., anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids. Hence, we aimed at exploring the antioxidant potential of the leaf extract of Spondias mombin by in vitro methods. The ethanolic extract of leaves was subjected to spectrophotometric analysis and DPPH methods to explore its reducing potential. The total phenolic and total flavonoid content was estimated by colorimetric methods. It was observed that ethanolic extract of Spondias mombin demonstrated a dose-dependent increase in the reducing property, with higher potency than the reference compound sodium metabisulphate. Spondias mombin shade dried leaf powder macerated and later extracted with hot water possessed a significantly high content of flavonoids than those extracted with other solvents. The leaf extract of Spondias mombin possesses significant antioxidant activity that may be attributed to its high flavonoid content which could afford protection in inflammatory conditions. This finding strengthens its widespread use in traditional medicine. Animal studies and clinical trials are necessary to validate these beneficial properties and translate them into clinical utility.

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Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Bhandarkar¹,

Bhat²,

Vinodraj³

et al. 2015

Int. Res. J. Pharm.

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“…The increase in LP observed may be due to pulmonary tuberculosis or carcinogenesis induced by ROS. The parallel decrease in SOD could be due to inactivation by ROS (25). Recently, it has been observed that free radicals attack proteins, mainly enzymes (DT-36) (26).…”

Section: Discussionmentioning

confidence: 99%

Serum Malondialdehyde Levels and Superoxide Dismutase Activities in Pulmonary Tuberculosis and Lung Cancers

Güney¹,

Bi̇lgi̇han²,

Çiftçi³

et al. 2004

Ankara Sa

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Objectives: An increasing amount of epidemiological and experimental evidence has been carried out on the relationship between free radical activity and malignancy. The imbalance between free radical production and cellular defense mechanisms has been described in cancers and degenerative diseases like tuberculosis (tb).Methodology: The present investigation has been undertaken to study the levels of lipid peroxide (LP) and antioxidant enzyme superoxide dismutase (SOD) activities in sera of lung cancers (Lc) and tb. Forty-two patients and fourteen healthy cases were enrolled into the study. Group I had seventeen subjects with Lc, group II had twenty-five patients with tb and group III had fourteen healthy cases. The malondialdehide (MDA) and superoxide dismutase (SOD) activities in sera were quantified.Results: Serum MDA levels in the whole group of patients (Lc and tb) were much higher than in healthy controls. The levels of MDA did not change significantly in the group I vs. group II (p>0,05). The SOD activity in sera from patients with Lc was markedly lower than the other two groups. Activities of SOD in group I significantly decreased as compared to the group II (p<0,001). In the present study although LP levels increased in both tb and Lc patients, the activities of SOD in Lc cases were significantly higher than tb patients.

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“…In addition, taxifolin (dihydroquercetin, Figure 1) has been shown to exhibit anti-inflammatory effects and protect against oxidative cellular injury in rat peritoneal macrophages [14] and human endothelial cells [15], possibly by inhibiting the expression of intercellular adhesion molecule-1 (ICAM-1) [16] and Mac-1 (CD11b/CD18), a dominant b2 integrin in activated neutrophils [17]. Expression of ICAM-1 on inflammatory target cells (e.g., endothelial cells) mediates activation and firm adhesion of circulating neutrophils to injured tissue through interaction with b2 integrin expressed on neutrophils [18].…”

Section: Introductionmentioning

confidence: 99%

Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation

Wang¹,

et al. 2005

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SummaryInfarction in adult rat brain was induced by middle cerebral arterial occlusion (MCAO) followed by reperfusion to examine whether taxifolin could reduce cerebral ischemic reperfusion (CI/R) injury. Taxifolin administration (0.1 and 1.0 lg/kg, i.v.) 60 min after MCAO ameliorated infarction (by 42%±7% and 62%±6%, respectively), which was accompanied by a dramatic reduction in malondialdehyde and nitrotyrosine adduct formation, two markers for oxidative tissue damage. Overproduction of reactive oxygen species (ROS) and nitric oxide (NO) via oxidative enzymes (e.g., COX-2 and iNOS) was responsible for this oxidative damage. Taxifolin inhibited leukocyte infiltration, and COX-2 and iNOS expressions in CI/R-injured brain. Taxifolin also prevented Mac-1 and ICAM-1 expression, two key counter-receptors involved in firm adhesion/transmigration of leukocytes to the endothelium, which partially accounted for the limited leukocyte infiltration. ROS, generated by leukocytes and microglial cells, activated nuclear factor-kappa B (NF-jB) that in turn signaled up-regulation of inflammatory proteins. NF-jB activity in CI/R was enhanced 2.5-fold over that of sham group and was inhibited by taxifolin. Production of both ROS and NO by leukocytes and microglial cells was significantly antagonized by taxifolin. These data suggest that amelioration of CI/R injury by taxifolin may be attributed to its antioxidative effect, which in turn modulates NF-jB activation that mediates CI/R injury.

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Quercetin Protects Cutaneous Tissue-Associated Cell Types Including Sensory Neurons From Oxidative Stress Induced By Glutathione Depletion: Cooperative Effects of Ascorbic Acid

Cited by 165 publications

References 65 publications

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Serum Malondialdehyde Levels and Superoxide Dismutase Activities in Pulmonary Tuberculosis and Lung Cancers

Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation

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