Quinone dependent NADH dehydrogenation in mitochondria-like particles from Setaria digitata, a filarial parasite

Flavonoids and Related Compounds in Parasitic Disease Control

“…Its activity again depends on the parasite concerned. Rotenone is active against Setaria cervi and Strongyloides ratti [61][62][63][64] and inactive against Setaria digitata [61].…”

The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

“…The reduction of O 2 in the filarial parasite S. digitata has always fascinated the group ever since it was found out that H 2 O 2 is one of the products formed and that the process is associated with the generation of ATP (13,27). Though the generation of H 2 O 2 in Setaria is relatively high, the activity of scavenger enzyme catalase, designed to neutralize H 2 O 2 , is not proportionately high (12).…”

Setaria digitata in advancing our knowledge of human lymphatic filariasis

“…One such pathway is substrate-dependent, involving a readily auto-oxidizable quinone, Q 6 , which mediates electron transfer from flavoprotein dehydrogenases to oxygen in the electron transport chain (Santhamma & Raj, 1990). The presence of a quinone that links electron transfer from both aerobic and anaerobic pathways was found to be unique to S. digitata (Sivan & Raj, 1992). The reduction of oxygen would produce H 2 O 2 which is detoxified by catalase.…”