Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO2-induced senescent mice

Wang, Peipei; Sun, Hongxiang; Liu, Cejia; Hu, Ming-Hong; He, Xiaohui; Yue, Su; Jiao, Ze-Zhao; Xiang, Lan

doi:10.1016/j.phymed.2016.02.014

Cited by 19 publications

(18 citation statements)

References 21 publications

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“…The dose of D-gal covered a wide range wherein the minimal dose could be 50 mg/kg ( 25 ), while the higher dose could be 1,250 mg/kg ( 26 ). The modeling period usually ranges from 6 to 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose

Zhao¹,

Li²,

Zhao³

et al. 2018

Food & Nutrition Research

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BackgroundMany plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract.ObjectiveTo investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal.Design70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks. Total antioxidant capacity (T-AOC), super dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, liver and brain were determined. The expression of Heme Oxygenase (HO-1), iNOS and Klotho in liver and brain were obtained.ResultsWOC could improve the pathologic lesions caused by oxidative stress and significantly enhance the T-AOC, increase the activities of SOD, GSH-Px and decrease the contents of MDA in serum, liver and brain. Also, the WOC could obviously up-regulate the expression of HO-1 and Klotho and down-regulate the expression of iNOS.ConclusionWOC can be used as an anti-aging food for its effectively eliminating free radicals, enhancing the antioxidant capacity and alleviating the damages of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose

Zhao¹,

Li²,

Zhao³

et al. 2018

Food & Nutrition Research

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“…After 65 days of treatment, all mice were subjected to the water maze task as reported previously, with slight modifications [65]. Briefly, the experimental apparatus was composed of a circular, black pool (100 cm in diameter, 35 cm in height) filled with water (23 ± 1 °C) containing a black, edible pigment.…”

Section: Methodsmentioning

confidence: 99%

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Chen

Zhu

et al. 2019

Aging

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Gut dysbiosis and oxidative stress may trigger senile osteoporosis. Fructus Ligustri Lucidi (FLL) has bone-preserving properties and affects the intestinal microecology. However, the mechanism of the anti-osteoporotic effect of FLL and its link to the gut microbiota remains to be elucidated. Here, we demonstrated that sustained exposure of ICR mice to D-galactose / sodium nitrite for 90 days causes aging-related osteoporosis and reduced cognitive performance. The aging phenotype is also characterized by increased oxidative stress in serum. This is likely triggered by abnormal changes in the gut microbiota population of Bifidobacterium and the ratio of Firmicutes/ Bacteroidetes that resulted in increased levels of flavin-containing monooxygenase-3 and trimethylamine-N-oxide (TMAO). Moreover, the increased oxidative stress further accelerated aging by increasing tumor necrosis factor-α levels in serum and reducing Sirtuin 6 (Sirt6) expression in long bones, which prompted nuclear factor kappa-B acetylation as well as over-expression and activation of cathepsin K. FLL-treated aging mice revealed a non-osteoporotic bone phenotype and an improvement on the cognitive function. The mechanism underlying these effects may be linked to the regulation of gut microbiota diversity, antioxidant activity, and the levels of TMAO and Sirt6. FLL may represent a potential source for identifying anti-senile osteoporotic drug candidates.

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“…Oleracein E ( 403 ) has a rare tetrahydroisoquinoline/pyrrolidone tricyclic skeleton and a catechol moiety 300 . It improved cognitive function, reversed abnormal brain antioxidant biomarkers (GSH, T‐AOC, MDA, and SOD) to normal levels, and inhibited hippocampal neuronal apoptosis in d ‐galactose/NaNO 2 ‐induced senescent mice and in some apoptotic indices induced by AlCl 3 301,302 …”

Section: Bioactivitiesmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

146

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO2-induced senescent mice

Cited by 19 publications

References 21 publications

Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose

Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Biologically active isoquinoline alkaloids covering 2014–2018

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