RADBIOMOD: A simple program for utilising biological modelling in radiotherapy plan evaluation

Chang, Joe H; Gehrke, Christopher; Prabhakar, R; Gill, Suki; Wada, M.; Joon, Daryl Lim; Khoo, Vincent

doi:10.1016/j.ejmp.2015.10.091

Cited by 23 publications

(20 citation statements)

References 32 publications

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“…Figure 3 shows the NTCP distribution for 3D-CRT, IMRT and VMAT. We used RADBIOMOD, a simple program for calculation of complication probabilities 24 Figure 3 Normal tissue complication probabilities (values in %).…”

Section: Resultsmentioning

confidence: 99%

“…RADBIOMOD, a simple program for utilising biological modelling in radiotherapy plan evaluation was used. It has been developed using Visual Basic for Applications for Microsoft Excel that incorporates multiple different biological models for radiotherapy plan evaluation, including modified Poisson tumour control probability (TCP), modified Zaider–Minerbo TCP, Lyman–Kutcher–Burman normal tissue complication probability (NTCP), equivalent uniform dose (EUD), EUD-based TCP, EUD-based NTCP and uncomplicated TCP 24 …”

Section: Introductionmentioning

confidence: 99%

“…It has been developed using Visual Basic for Applications for Microsoft Excel that incorporates multiple different biological models for radiotherapy plan evaluation, including modified Poisson tumour control probability (TCP), modified Zaider-Minerbo TCP, Lyman-Kutcher-Burman normal tissue complication probability (NTCP), equivalent uniform dose (EUD), EUD-based TCP, EUDbased NTCP and uncomplicated TCP. 24 Consequently, we chose tumours of the nasopharynx (cavum) involving the base of the skull, that have been irradiated by 3D-CRT, IMRT and VMAT techniques for curative purpose in the multimodal combined hormoneradiation therapy treatment. We evaluate the integrity of nerve structures belonging to the cervical-cephalic segment (spinal cord, brainstem, optical chiasm, optical nerves, brain) both in terms of structural integrity, dose coverage and of possible clinical complications.…”

Section: Introductionmentioning

confidence: 99%

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Radiation-induced biological changes of neural structures in the base of the skull tumours

et al. 2017

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Background and purposeThe aim of this paper is to compare neural induced changes in three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for nasopharyngeal cancers.Materials and methodsRadiotherapy plans for 10 patients with nasopharyngeal cancer stages III and IV were prospectively developed for 3D-CRT, IMRT and VMAT using Varian Eclipse planning system. The same radiation therapist carried out all planning and the same clinical dosimetric constraints were used. Normal tissue complication probabilities were calculated.ResultsThe mean planning target volume’s (PTVs) conformity index (CI) for 3D-CRT was 1·424, for IMRT 1·1, and for VMAT 1·081. The PTV homogeneity (HI) index was 0·204 for 3D-CRT, 0·124 for IMRT and 0·153 for VMAT. Normal tissue complication probabilities gave complex results for 3D-CRT, IMRT and VMAT and are analysed in detail in this paper. The mean monitor units were 95 (range 9–180) for 3D-CRT; 165 (range 52–277) for IMRT; and 331 (range 167–494) for VMAT (p<0·05).ConclusionsVMAT is associated with similar dosimetric advantages as IMRT over 3D-CRT for nasopharyngeal cancer. VMAT is associated with faster delivery times and greater number of mean monitor units than IMRT. Brain radionecrosis severity and risk, in the past, have been underestimated. By improving the life expectancy of patients with nasopharyngeal cancer to ensure maintenance of the neural structures, recommended dose limits should be considered as a first degree priority (as the spinal cord, brainstem, etc.) when IMRT and VMAT plans are implemented.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiation-induced biological changes of neural structures in the base of the skull tumours

et al. 2017

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“…The computed NTCP values were used in a relative sense for comparisons between IMRT, VMAT, and 3D-PSPBT. All NTCPs were computed from EQD2 DVH's ASCII files by using RADBIOMOD software (28). Reductions in NTCP provided by 3D-PSPBT in comparison with IMRT ( NTCP IMRT−PSPBT ) and VMAT ( NTCP IMRT−PSPBT ) were also computed.…”

Section: Normal Tissue Complication Probability Evaluationmentioning

confidence: 99%

Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

et al. 2020

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Background: Radiobiological model-based studies of photon-modulated radiotherapy for pancreatic cancer have reported reduced gastrointestinal (GI) toxicity, although the risk is still high. The purpose of this study was to investigate the potential of 3D-passive scattering proton beam therapy (3D-PSPBT) in limiting GI organ at risk (OAR) toxicity in localized pancreatic cancer based on dosimetric data and the normal tissue complication probability (NTCP) model. Methods: The data of 24 pancreatic cancer patients were retrospectively analyzed, and these patients were planned with intensity-modulated radiotherapy (IMRT), volume-modulated arc therapy (VMAT), and 3D-PSPBT. The tumor was targeted without elective nodal coverage. All generated plans consisted of a 50.4-GyE (Gray equivalent) dose in 28 fractions with equivalent OAR constraints, and they were normalized to cover 50% of the planning treatment volume (PTV) with 100% of the prescription dose. Physical dose distributions were evaluated. GI-OAR toxicity risk for different endpoints was estimated by using published NTCP Lyman-Kutcher-Burman (LKB) models. Analysis of variance (ANOVA) was performed to compare the dosimetric data, and NTCP IMRT−PSPBT and NTCP VMAT−PSPBT were also computed. Results: Similar homogeneity and conformity for the clinical target volume (CTV) and PTV were exhibited by all three planning techniques (P > 0.05). 3D-PSPBT resulted in a significant dose reduction for GI-OARs in both the low-intermediate dose range (below 30 GyE) and the highest dose region (D max and V 50 GyE) in comparison with IMRT and VMAT (P < 0.05). Based on the NTCP evaluation, the NTCP reduction for GI-OARs by 3D-PSPBT was minimal in comparison with IMRT and VMAT. Raturi et al. Proton vs. Photon-Modulated Radiotherapy in Pancreas Conclusion: 3D-PSPBT results in minimal NTCP reduction and has less potential to substantially reduce the toxicity risk of upper GI bleeding, ulceration, obstruction, and perforation endpoints compared to IMRT and VMAT. 3D-PSPBT may have the potential to reduce acute dose-limiting toxicity in the form of nausea, vomiting, and diarrhea by reducing the GI-OAR treated volume in the low-to-intermediate dose range. However, this result needs to be further evaluated in future clinical studies.

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“…Where TD 50 is the dose which, if the entire organ is uniformly irradiated, would cause a 50% chance of normal tissue complication; m is the slope parameter; and n is the volume effect parameter. All the radiobiological parameters were calculated using the free available RADBIOMOD Visual Basic application-based software in Microsoft Excel [21]. For the TCP and EUD calculation of the tumour, the value of parameters used at different tumour sites were as follows.…”

Section: Analysis Of the Dose Volume Histogram And Radiobiological Pamentioning

confidence: 99%

Analysis of Influence of Errors in Angular Settings of Couch and Collimator on the Dosimetric and Radiobiological Parameters in VMAT Plans

Noufal

Abdullah

Niyas

et al. 2017

Journal of Medical Imaging and Radiation Sciences

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Objective: To evaluate the impact of couch and collimator angular variations on dose volume histogram (DVH), tumour control probability (TCP), and normal tissue complication probability (NTCP) of the volumetric-modulated arc therapy (VMAT) plans. Methods: Stereotactic radiosurgery and stereotactic body radiation therapy VMAT plans were generated for three different hypothetical planning target volumes (PTVs) that mimic brain metastases, single brain lesion, and single spine lesion. Thirty routine VMAT plans (10 prostate, 10 head and neck, and 10 brain cases) treated in our clinic were also selected for this study. The plans were generated using an Eclipse Treatment Planning System and delivered using a Clinac iX linear accelerator equipped with a Millennium 120 multileaf collimator. All the plans were generated using two complementary full arcs (with gantry angle from 179 to 181 and collimator rotation of 30 and 330) except the brain tumour cases, which used single full arc with collimator rotation of 30. In all the cases, the couch angle was zero. Impact of the angular variations in the collimator and couch was studied by varying the collimator and couch angular settings by 1 , 2 , and 3 , and creating six erroneous plans corresponding to the original plans. The variation due to these errors on different DVH and radiobiological parameters (TCP, equivalent uniform dose (EUD), and NTCP) of the PTVs and organs-at-risk (OARs) were observed. The relative percentage of difference in these parameters (DD, DTCP, DEUD, and DNTCP) were analysed, and statistical significance was tested. Results: The variation due to collimator misplacement was observed to be larger than the couch misplacement. Furthermore, in both cases, the variation increased as the degree of error increased. Among the DVH parameters, D 98% , D 95% , and V 95Gy were affected more by the errors than D 2% , D 5% , and D 50% , in both hypothetical and clinical PTVs. In the clinical PTVs, the TCP showed the most variation among all parameters. The DNTCP of the bladder and brain OARs were zero, whereas for head and neck OARs, it was high.

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RADBIOMOD: A simple program for utilising biological modelling in radiotherapy plan evaluation

Cited by 23 publications

References 32 publications

Radiation-induced biological changes of neural structures in the base of the skull tumours

Radiation-induced biological changes of neural structures in the base of the skull tumours

Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

Analysis of Influence of Errors in Angular Settings of Couch and Collimator on the Dosimetric and Radiobiological Parameters in VMAT Plans

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