Radiation Sterilization of Antibiotics in Solid State

Abstract

: Radiation sterilization is a promising method of obtaining sterile active pharmaceutical ingredients (API), excipients and formulations. One of the best methods of sterilization is to use ionizing radiation. The greatest advantage of ionizing radiation is fact that can be conducted at room temperature or lower. Therefore this procedure of sterilization is reserved for drugs sensitive to the high temperature of autoclaving. Solutions of parenterally administered antibiotics must be absolutely aseptic. Most of the antibiotics are susceptible for the degradation at increased temperature and humidity so radiation is often used to obtain sterile bactericidal drugs.

Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

“…There is no need to add any initiator and the product is highly pure. At the same time, irradiation has a bactericidal function, making it more suitable for research in the biomedical field [ 82 , 83 ]. Irradiation cross-linking can be utilized to form polymers from free radicals initiated by electron beams, γ-rays, and X-rays [ 84 ].…”

Electron beam radiation constructed and improved bone repairing performance based on hierarchical thermoplastic polyurethane/graphene oxide/hydroxyapatite hot melt adhesive with high flow ductility

“…Additionally, radiation possesses bactericidal properties, making it particularly suitable for biomedical research. 16,17 Gamma ray radiation refers to high-energy electromagnetic radiation that is emitted from the atomic nucleus during radioactive decay or nuclear reactions, while the electron beam radiation relies on using an electron accelerator to crosslink electrons with substances, inducing ionization and excitation effects. 18 Electron beam radiation provides flexibility in controlling the radiation dose in comparison to gamma rays.…”