Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

Yang, Jiang; Rao, Lu; Wang, Yayang; Zhao, Yuan; Li, Dongliang; Wang, Zhijun; Fu, Lili; Wang, Yifan; Yang, Xiaojie; Li, Yuesheng; Liu, Yi

doi:10.3390/polym14204377

Cited by 14 publications

(8 citation statements)

References 115 publications

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“…The CS/Na‐Alg/PAAc hydrogel in this research was created through copolymerization and chemical cross‐linking via gamma radiation. The utilization of ionizing radiation technology in the gelation and cross‐linking of hydrogels is very impactful 51 . Gamma radiations are well known for their ability to polymerize monomers by generating free radicals.…”

Section: Resultsmentioning

confidence: 99%

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Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel

Mahmoud

Sayed

Abdel-Raouf

et al. 2023

J of Applied Polymer Sci

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This research article aimed to assist the works conducted to save water resources, which are rapidly depleted as a result of climate change by eliminating toxic chromium ions Cr(VI) from simulated solution. In this regard, chitosan/Na‐alginate/polyacrylic acid (CS/Na‐Alg/PAAc) and Ni/chitosan/Na‐alginate/polyacrylic acid (Ni@CS/Na‐Alg/PAAc) were created as eco‐friendly hydrogel composites via gamma radiation. The hydrogel matrix served as a basin for the in‐situ formation of Ni nanoparticles. The prepared composites were characterized by the FTIR and XRD analyses. The surface morphology of the nanocomposite was also verified via the SEM. It exhibited a dense packing of the Ni nanoparticles representing about 2.5% of the atomic percentage depicted by the EDX analysis. The swelling performance was investigated versus different pH values and the maximum swelling percent was attained as a non‐Fickian character at pH = 13 and 5 for CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc, respectively. Furthermore, the surface topographies of CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc loaded with Cr(VI) were examined by AFM at different pH values. The maximum Cr(VI) removal was top achieved at pH 8 (58.06 and 74.5 mg/g for CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc, respectively) and best fit with the Freundlich isotherm model with calculated RL values indicated a favorable adsorption.

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Section: Resultsmentioning

confidence: 99%

“…The utilization of ionizing radiation technology in the gelation and cross-linking of hydrogels is very impactful. 51 Gamma radiations are well known for their ability to polymerize monomers by generating free radicals. In addition, it can proceed with a cross-linking reaction between polymer chains.…”

Section: Preparation Of Ni@cs/na-alg/ Paac Nanocompositementioning

confidence: 99%

Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel

Mahmoud

Sayed

Abdel-Raouf

et al. 2023

J of Applied Polymer Sci

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“…This can be achieved using chemical or radiation-based methods, leading to the formation of functional hydrogels with specific properties. Radiation crosslinking uses sources such as electron beams, gamma radiation, or X-rays to generate free radicals in the polymer, resulting in crosslinking [88,89]. This method is preferred because of its ability to modify biopolymers without the need for chemical additives while ensuring biocompatibility and cost-effectiveness [90][91][92].…”

Section: Hydrogels: Concept Synthesis and Biomedical Applicationsmentioning

confidence: 99%

Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review

De Leon-Oliva,

Boaru,

Perez-Exposito

et al. 2023

Gels

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Bone and cartilage tissue play multiple roles in the organism, including kinematic support, protection of organs, and hematopoiesis. Bone and, above all, cartilaginous tissues present an inherently limited capacity for self-regeneration. The increasing prevalence of disorders affecting these crucial tissues, such as bone fractures, bone metastases, osteoporosis, or osteoarthritis, underscores the urgent imperative to investigate therapeutic strategies capable of effectively addressing the challenges associated with their degeneration and damage. In this context, the emerging field of tissue engineering and regenerative medicine (TERM) has made important contributions through the development of advanced hydrogels. These crosslinked three-dimensional networks can retain substantial amounts of water, thus mimicking the natural extracellular matrix (ECM). Hydrogels exhibit exceptional biocompatibility, customizable mechanical properties, and the ability to encapsulate bioactive molecules and cells. In addition, they can be meticulously tailored to the specific needs of each patient, providing a promising alternative to conventional surgical procedures and reducing the risk of subsequent adverse reactions. However, some issues need to be addressed, such as lack of mechanical strength, inconsistent properties, and low-cell viability. This review describes the structure and regeneration of bone and cartilage tissue. Then, we present an overview of hydrogels, including their classification, synthesis, and biomedical applications. Following this, we review the most relevant and recent advanced hydrogels in TERM for bone and cartilage tissue regeneration.

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“…It has good biocompatibility, excellent flexibility, structural designability, and functional adjustability [ 11 ]. In addition, hydrogels can sense small changes in external stimuli (such as temperature and pH value) and achieve their response to stimuli by swelling and contracting [ 12 ]. The excellent properties of hydrogels have aroused the interest of the majority of scientific research workers and made them widely used in several fields.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

Self Cite

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

Cited by 14 publications

References 115 publications

Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel

Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel

Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

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