Radiation synthesis of pH-sensitive 2-(dimethylamino)ethyl methacrylate/ polyethylene oxide/ZnS nanocomposite hydrogel membrane for wound dressing application

pH-Responsive wound dressings: advances and prospects

“…According to their results, the minimum inhibitory concentration decreased by 2–16 times after adding ZnS, which effectively increased the ability to inhibit infection. 34 Similar results were also presented by Hu et al , where the addition of silver nanoparticles (AgNPs) significantly improved the antibacterial properties of the hydrogel. Compared with the control group, the hydrogel@AgNPs exhibited a better antibacterial effect (survival rates of 17.8 ± 2.2% for S. aureus and 19.7 ± 2.8% for E. coli ), and the antibacterial ability was increased by more than five times.…”

“…The different swelling behaviors are generally attributed to protonation, deprotonation, and charge repulsion of the functional groups in the material components. [33][34][35] For example, pH-sensitive composite hydrogels prepared by Al-Arjan et al showed a high curcumin release at pH 7.4. At this pH, the hydrophilic groups on bacterial cellulose (BC), polyvinyl alcohol (PVA), and graphene oxide (GO) caused swelling owing to hydrogen bonds and electrostatic repulsion forces.…”

pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

“…The strong peak of 3385.07 cm −1 proved the existence of hydroxyl absorption ( Figure 1 A). The FT-IR of PDM showed two characteristic peaks at 1647.21 and 1728.22 cm −1 , which were attributed to –C=C and –C=O, respectively, and 1350 cm −1 was the –CO stretch [ 18 ]. The peak located at 2848.86 cm −1 was attributed to the –CH bond stretching vibration of –N(CH 3 ) 2 .…”

“…Wang et al [ 17 ] used photothermally sensitive polydopamine nanoparticles (NPs) modified with poly[(2-methacryloyloxy)ethyl phosphorylcholine-b-(2-dimethylamino)ethyl methacrylate] diblock copolymers to achieve near-infrared photothermal therapeutic and pH-sensitive drug release. Ghobashy et al [ 18 ] prepared pH-responsive hydrogels using 2-(dimethylamino)ethyl methacrylate, polyethylene oxide, and ZnS NPs and investigated the release behavior of the hydrogels and the cumulative release of drugs increased from 40% at pH 4 to 96% at pH 7. Foss et al [ 19 ] developed nanospheres of crosslinked networks of methacrylic acid grafted with poly(ethylene glycol), and acrylic acid grafted with poly(ethylene glycol) nanospheres for use as oral INS delivery devices.…”

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

“…Gels are semisolid, resilient, soft, pliable, and high-water-content polymers that are ideal for tissue engineering and local compound/transcription factor delivery because to their great adhesiveness, cytocompatibility, and processability [ 85 ]. Hydrogels are often composed of more than 90% water and exhibit typical physical behavior such as dependability and stability, physical strength, uniformity, and processability [ 86 ]. Chitosan may be used to make two types of hydrogels: chemical gels cross-linked using multifunctional agents such as epichlorohydrin [ 87 ], glutaraldehyde [ 88 ], diethyl squarate [ 89 ], and physical gels which are formed from low energy junctions [ 90 ].…”