Radiofrequency ablation as local therapy for early breast carcinomas

Abstract

RF ablation is a safe and promising minimally invasive treatment for small breast carcinomas with pathological tumor size ≤ 2 cm in diameter and without EIC.

Minimally invasive ablative techniques in the treatment of breast cancer: a systematic review and meta-analysis

“…A total of 63 articles matched the selection criteria. The 63 articles included 16 feasibility studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], 12 phase I studies [29][30][31][32][33][34][35][36][37][38][39][40], nine phase II studies [41][42][43][44][45][46][47][48][49], three comparative studies [50][51][52], one retrospective study [53], and four randomised controlled trials [54][55][56]. In 18 studies the type of study was not reported [8,[57][58][59][60][61][62][63][64]…”

“…In five studies [21,24,49,59,63], patients withdrew from the study during or after treatment and in another six studies [15,26,44,48,49,72] patients withdrew before the start of the treatment. The overall STROBE score ranged from four to seven (mean…”

“…Axillary treatment was performed prior to ablative treatment (n=17), after ablative treatment (n=2), along with surgical excision (n=14), or the timing was not specified (n=7). Sentinel lymph node biopsy (SLNB) in immediate surgical excision studies was often performed just prior to the ablative treatment, [14,15,48], five cases of blistering [51], four of coagulative changes to the skin [51], three were cases of ecchymosis [27,46], three cases of nipple retraction, [31] two case of pneumothorax [15,64], two incidences of skin puckering [44], two infections [42,44] and single cases of overreaction [30] and fistula [47] (table 1a). With cryo-ablation 10.9% of patients (20/183) J U S T A C C E P T E D developed a complication, these were skin necrosis (n=5) [61], haematoma (n=5) [22,73], ecchymosis (n=4) [22], skin retraction (n=2) [73], seroma (n=2) [19,20], arterial bleeding (n=1) [20] and skin ulceration (n=1).…”

High Temperature Hyperthermia in Breast Cancer Treatment

“…Currently Takayuki [22] et al treated 49 patients, aged 36 -82 years and tumor size ≤3.0 cm in diameter (range 0.5-3.0 cm) on US examination. Under US guidance, the 17-gauge ValleylabTM RF Ablation System with Cool-tip TM Technology (Covidien, Energy-Based Devices, Interventional Oncology, Boulder, CO) was inserted in the center of the tumor.…”

“…A FEM model was used in this work because it can provide users with quick, accurate solutions to multiple systems of differential equations and therefore, they are well suited to solve heat transfer problems like ablation [27]. Numerous MWA antenna designs specifically targeted for MWA cardiac and hepatic applications have been reported [20][21][22][23][24], but they have not been used to treat breast cancer. These designs have been focused largely on thin, coaxial-based interstitial antennas [28], which are minimally invasive and capable of delivering a large amount of electromagnetic power.…”