Radiopacity in bone cements using an organo-bismuth compound

Deb, Sanjukta; Abdulghani, Saba; Behiri, J.C.

doi:10.1016/s0142-9612(02)00039-x

Cited by 72 publications

(64 citation statements)

References 8 publications

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“…The mechanical properties to some extent follow what was found when the addition of triphenyl bismuth (TPB) as an opacifier to a bone cement was investigated [17,18]. They found that the ultimate tensile strength of bone cement which contained 10 wt% TPB powder, stored in distilled water for two weeks in 37 ºC prior to testing, was 42.95 MPa, similar to our findings.…”

Section: Discussionsupporting

confidence: 89%

Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement

Kjellson

Abdulghani

Tanner

et al. 2007

J Mater Sci: Mater Med

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Section: Discussionsupporting

confidence: 89%

Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement

Kjellson

Abdulghani

Tanner

et al. 2007

J Mater Sci: Mater Med

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“…The system used to demonstrate the approach involved blending a radiolucent polymer (pDTEc) with an iodinated, radiopaque polymer (pI 2 DTEc). The combinatorial approach could also be applied to systems where inclusion of heavy atom salts [2,3] or small organic molecules [4] are used to impart radiopacity. The pure polymer would be loaded in one syringe pump (as shown in Fig.…”

Section: Potential Application To Other Polymer Systemsmentioning

confidence: 99%

“…Approaches for adding heavy atoms include: (1) physical mixture of salts, such as addition of barium sulfate to poly(methylmethacrylate) (PMMA) [2] or poly(D,L-lactic acid) [3], (2) blends with organic compounds, such as blending triphenyl bismuth with PMMA [4], and (3) covalent linkage of heavy atoms to the polymer backbone [5], such as iodinating pDTEc to yield pI 2 DTEc [6,7]. Each approach has its own advantages and disadvantages (reviewed in Ref.…”

Section: Introductionmentioning

confidence: 99%

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X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods

et al. 2008

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We have developed a combinatorial method for determining optimum tissue scaffold composition for several X-ray imaging techniques. X-ray radiography and X-ray microcomputed tomography enable non-invasive imaging of implants in vivo and in vitro. However, highly porous polymeric scaffolds do not always possess sufficient X-ray contrast and are therefore difficult to image with X-ray-based techniques. Incorporation of high radiocontrast atoms, such as iodine, into the polymer structure improves X-ray radiopacity but also affects physicochemical properties and material performance. Thus, we have developed a combinatorial library approach to efficiently determine the minimum amount of contrast agent necessary for X-ray-based imaging. The combinatorial approach is demonstrated in a polymer blend scaffold system where X-ray imaging of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) (pDTEc) scaffolds is improved through a controlled composition variation with an iodinated-pDTEc analog (pI 2 DTEc). The results show that pDTEc scaffolds must include at least 9%, 16%, 38% or 46% pI 2 DTEc (by mass) to enable effective imaging by microradiography, dental radiography, dental radiography through 0.75 cm of muscle tissue or micro-computed tomography, respectively. Only two scaffold libraries were required to determine these minimum pI 2 DTEc percentages required for X-ray imaging, which demonstrates the efficiency of this new combinatorial approach for optimizing scaffold formulations.

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“…Due to this incompatibility with the polymeric matrix, the contrast forms a segregated phase and makes mixing of reagents more difficult during the preparation. For this reason, some authors have suggested the use of alternative contrasts, such as iodine (Almén, 1995;Davy et al, 1997;Davenport et al, 1999;Ginebra et al, 2002;Nakamura et al, 2003;Artola et al, 2004;Kjellson et al, 2004;Van Hooy-Corstjensa et al, 2004) and/or bismuth (Rawls et al, 1996;Deb et al, 2002) based compounds. These compounds are chemically linked to specially designed monomers and are thus automatically incorporated into the BC formulation.…”

Section: Verified That It Is Verymentioning

confidence: 99%

Production of bone cement composites: effect of fillers, co-monomer and particles properties

Santos¹,

Pita²,

Melo³

et al. 2011

Braz. J. Chem. Eng.

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-Artificial bone cements (BCs) based on poly(methyl methacrylate) (PMMA) powders and methyl methacrylate (MMA) liquid monomer also present in their formulation small amounts of other substances, including a chemical initiator compound and radiopaque agents. Because inadequate mixing of the recipe components during the manufacture of the bone cement may compromise the mechanical properties of the final pieces, new techniques to incorporate the fillers into the BC and their effect upon the mechanical properties of BC pieces were investigated in the present study. PMMA powder composites were produced insitu in the reaction vessel by addition of X-ray contrasts to the reacting MMA mixture. It is shown that this can lead to much better mechanical properties of test pieces, when compared to standard bone cement formulations, because enhanced dispersion of the radiopaque agents can be achieved. Moreover, it is shown that the addition of hydroxyapatite (HA) and acrylic acid (AA) to the bone cement recipe can be beneficial for the mechanical performance of the final material. It is also shown that particle morphology can exert a tremendous effect upon the performance of test pieces, indicating that the suspension polymerization step should be carefully controlled when optimization of the bone cement formulation is desired.

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Radiopacity in bone cements using an organo-bismuth compound

Cited by 72 publications

References 8 publications

Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement

Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement

X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods

Production of bone cement composites: effect of fillers, co-monomer and particles properties

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