Radioprotective potential and chelating properties of glycylhistamine, an analog of histamine terminal peptides found in bee venom

Peck, M. Larry; O’Connor, Rod; Johnson, Timothy James; Isbell, A. F.; Martell, Arthur E.; McLendon, George; Neff, Rachel; Wright, David

doi:10.1016/0041-0101(78)90199-x

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Synthetic Components and Analogs1

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1980

2021

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Cited by 7 publications

(1 citation statement)

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“…208 / Journal of Chemical Education oprotective drug (5). The decision to study this particular type of molecule was made on the basis of the known radioprotective properties of histamine, possibly by its action as a freeradical scavenger, and the similar protective properties exhibited by many copper(II) chelating agents.…”

Section: Synthetic Components and Analogsmentioning

confidence: 99%

Bee sting: The chemistry of an insect venom

O’Connor¹,

Peck²

1980

J. Chem. Educ.

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Section: Synthetic Components and Analogsmentioning

confidence: 99%

Bee sting: The chemistry of an insect venom

O’Connor¹,

Peck²

1980

J. Chem. Educ.

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Chemistry and Pharmacology of Honey-bee Venom

Banks

Shipolini

1986

Venoms of the Hymenoptera

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Multinuclear NMR and potentiometric study on tautomerism during protonation and zinc(II) complex formation of some imidazole-containing peptide derivatives

Gajda¹,

Henry²,

Delpuech³

1994

J. Chem. Soc., Perkin Trans. 2

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The acid-base properties and zinc( ti) complexes of glycylhistamine, sarcosyl histamine, carcinine and carnosine have been studied by potentiometric, 13C and 14N N M R methods. Macroscopic species for the three states of protonation (LH;', LH +, L) and the corresponding microspecies involving three protonation sites (terminal amino, N -I and -3 imidazole nitrogens) are quantitatively estimated for the metal-free ligands. Zinc(ii) complexation is shown to reverse the tautomeric preference between 1 -and 3-H tautomeric forms of the imidazole ring (in LH' and L), as compared to the free ligands where the 1 -H tautomer is predominant.

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Radioprotective potential and chelating properties of glycylhistamine, an analog of histamine terminal peptides found in bee venom

Cited by 7 publications

References 7 publications

Bee sting: The chemistry of an insect venom

Bee sting: The chemistry of an insect venom

Chemistry and Pharmacology of Honey-bee Venom

Multinuclear NMR and potentiometric study on tautomerism during protonation and zinc(II) complex formation of some imidazole-containing peptide derivatives

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