Radioprotective role of clinical drug diclofenac sodium

Alok, Amit; Adhikari, Jawahar Singh; Chaudhury, N. K.

doi:10.1016/j.mrgentox.2013.06.015

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…However, in this study as in others (5-7), was chosen to evaluate the NSAID meloxicam as a radiationprotective agent. The great advantage of researching the radioprotective effect of NSAIDs is that these drugs are widely studied, even if not for this specific purpose, and their bioavailability, pharmacokinetics and side effects are well known (10). Moreover, it has been suggested that COX-2 inhibition may contribute to control of cancer progression and prevention of metastasis (25).…”

Section: Discussionmentioning

confidence: 99%

“…In order to mitigate oral complications, many radiationprotective agents have been studied with the aim of reducing the side effects due to radiotherapy on normal cells (5)(6)(7)(8)(9)(10)(11). Possible radioprotective effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been researched recently and positive results have been observed (5,6,10).…”

Section: Introductionmentioning

confidence: 99%

“…Possible radioprotective effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been researched recently and positive results have been observed (5,6,10). The ionizing radiation used in radiotherapy induces inflammation mediators in normal tissues, especially by activation of cyclooxygenase 2 (Cox-2) and damage may occur (5), thus justifying the research on NSAIDs as radiation-protective agents.…”

Section: Introductionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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This study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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“…The hallmark late effect of radiation exposure in several experimental animals is fibrosis, which is often permanent (Han et al, 2006;Lee et al, 2009;Flechsig et al, 2010;Qiu et al, 2011;Gorshkova et al, 2012;Cho et al, 2013;Ding et al, 2013;Horton et al, 2013). A number of chemical agents showed mitigation to radiation-induced injuries in animal models (Gandhi and Nair, 2004;Parihar et al, 2007;Thotala et al, 2009;Brown et al, 2010;Gao et al, 2012;Kma et al, 2012;Peebles et al, 2012;Alok et al, 2013;Copp et al, 2013).…”

Section: Lakhan Kmamentioning

confidence: 99%

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Kma¹

2014

Asian Pacific Journal of Cancer Prevention

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“…Diclofenac sodium (2-[(2,6-dichlorophenyl) amino] benzenacetic acid monosodium salt) is a synthetic non steroidal anti-inflammatory drug, widely employed for relief of pain, fever, inflammation associated to various infirmity processes, such as chronic arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and is sometimes used postoperatively (Alok et al, 2013). This drug shows short biological half-life (1-2h), attributed to a very rapid metabolism and elimination, and has high percentage capacity to bind with plasma protein (Dutta and Sahu, 2012).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Particles Produced From Sericin and Alginate Blend With Incorporated Drug

Silva¹,

Silva²,

Lima³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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-The use of biodegradable polymers for controlled release drug delivery systems are being widely studied, because the therapeutic benefits that can be achieved. Studies have shown that exposure of diclofenac sodium (DS) in acid medium, such as occurring after oral ingestion of the drug, decreases the antiinflammatory activity. Thus, the incorporation of the drug into biopolymer particles becomes an alternative and the therapeutic effect is maintained due to the protection offered by the biomaterials. The objective of this study is to evaluate the incorporation of diclofenac sodium in particles formed from the blend of sericin and alginate subjected to gelation process with CaCl 2 . Incorporation efficiency measurement, interaction and morphology of the drug with mixtures of biopolymers were made. Also, the particle characterization was carried out to analyze the physical-chemical parameters, such as the determination of the property pH ZPC.

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Radioprotective role of clinical drug diclofenac sodium

Cited by 18 publications

References 22 publications

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Preparation and Characterization of Particles Produced From Sericin and Alginate Blend With Incorporated Drug

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