Radiotherapy for liver cancer

Fukumitsu, Nobuyoshi; Okumura, Toshiyuki; Sakurai, Hideyuki

doi:10.1002/jgf2.19

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…In addition, chemotherapy, radiotherapy, molecular targeted therapy, immunotherapy, antiviral therapy, traditional Chinese medicine, and other adjuvant sexual therapy can effectively inhibit liver cancer. Among them, radiotherapy is not a first-line treatment plan for liver cancer, but it can be used as an effective means for local treatment of liver cancer [ 10 – 12 ]. Chemotherapy is a common treatment method in traditional cancer treatment, but it is more harmful to the liver, and it is easy to aggravate the symptoms of liver cirrhosis and hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Wang

Liang

Shi

et al. 2022

Applied Bionics and Biomechanics

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Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Wang

Liang

Shi

et al. 2022

Applied Bionics and Biomechanics

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“…Radiation therapy provides a non-invasive local treatment effect achieved through ionizing radiation. With time, X-ray radiation therapy has emerged, which is represented by three-dimensional conformal radiation therapy, stereotactic body radiation therapy, proton beam and particle beam therapies, which have rendered radiation therapy a safe and effective treatment option for liver cancer [42].…”

Section: Treatment Of Liver Cancermentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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Liver cancer has high incidence and mortality rates and its treatment generally requires the use of a combination treatment strategy. Therefore, the early detection and diagnosis of liver cancer is crucial to achieving the best treatment effect. In addition, it is imperative to explore multimodal combination therapy for liver cancer treatment and the synergistic effect of two liver cancer treatment drugs while preventing drug resistance and drug side effects to maximize the achievable therapeutic effect. Gold nanoparticles are used widely in applications related to optical imaging, CT imaging, MRI imaging, biomarkers, targeted drug therapy, etc., and serve as an advanced platform for integrated application in the nano-diagnosis and treatment of diseases. Dual-drug-delivery nano-diagnostic and therapeutic agents have drawn great interest in current times. Therefore, the present report aims to review the effectiveness of dual-drug-delivery nano-diagnostic and therapeutic agents in the field of anti-tumor therapy from the particular perspective of liver cancer diagnosis and treatment.

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“…Surgery, radiation, and chemotherapy are currently the most widely used treatments for malignant tumors. [1,2] However, after a longer period of clinical treatment, researchers discovered that these therapies do not always completely cure cancer, and even some patients still experience a variety of issues linked to subpar treatment outcomes, severe side effects, and a high risk of recurrence, which frequently result in more severe complication and may even be followed by bacterial infections after surgical resection. [3,4] A significant obstacle has always been the overcoming infection resistance, wound healing following tumor excision and cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Enzyme Activity of MIL‐101 (Fe)‐Derived Cascade Nano‐Enzymes for Antitumor and Antimicrobial Therapy

Sun,

Wang,

Zhuo

et al. 2023

Small

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The clinical application of oncology therapy is hampered by high glutathione concentrations, hypoxia, and inefficient activation of cell death mechanisms in cancer cells. In this study, Fe and Mo bimetallic sulfide nanomaterial (FeS2@MoS2) based on metal‐organic framework structure is rationally prepared with peroxidase (POD)‐, catalase (CAT)‐, superoxide dismutase (SOD)‐like activities and glutathione depletion ability, which can confer versatility for treating tumors and mending wounds. In the lesion area, FeS2@MoS2 with SOD‐like activity can facilitate the transformation of superoxide anions (O2−) to hydrogen peroxide (H2O2), and then the resulting H2O2 serves as a substrate for the Fenton reaction with FMS to produce highly toxic hydroxyl radicals (∙OH). Simultaneously, FeS2@MoS2 has an ability to deplete glutathione (GSH) and catalyze the decomposition of nicotinamide adenine dinucleotide phosphate (NADPH) to curb the regeneration of GSH from the source. Thus it can realize effective tumor elimination through synergistic apoptosis‐ferroptosis strategy. Based on the alteration of the H2O2 system, free radical production, glutathione depletion and the alleviation of hypoxia in the tumor microenvironment, FeS2@MoS2 NPS can not only significantly inhibit tumors in vivo and in vitro, but also inhibit multidrug‐resistant bacteria and hasten wound healing. It may open the door to the development of cascade nanoplatforms for effective tumor treatment and overcoming wound infection.

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Radiotherapy for liver cancer

Cited by 10 publications

References 19 publications

Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Multi‐Enzyme Activity of MIL‐101 (Fe)‐Derived Cascade Nano‐Enzymes for Antitumor and Antimicrobial Therapy

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