Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy

Yang, Lin; Chen, Xiangwu; Yu, Cancan; Xu, Guanghua; Nie, Xinxin; Cheng, Yu‐Fan; Luan, Yuxia; Song, Qingxu

doi:10.1016/j.actbio.2023.01.022

Cited by 58 publications

(31 citation statements)

References 31 publications

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“…While modern imaging techniques have made significant advances in diagnosing cancer, the accurate early detection of precancerous lesions and tumors remains challenging because of the inherent limitations of most imaging agents, including the inability to bypass biological barriers, poor biocompatibility, and instability . Most cancer treatments are limited to chemotherapy, radiotherapy, and surgery. − Of these, chemotherapy is used most frequently in treating various types of cancer. However, the nontarget tissue toxicity of conventional chemotherapeutic agents and multiple drug resistance severely restrict their efficacy in vivo. − Due to the disadvantages of traditional anticancer medications, there is a need to develop novel and efficient therapies that target the molecular modifications in tumor cells …”

Section: Cds In the Delivery Of Anticancer Drugsmentioning

confidence: 99%

Carbon Dots as Advanced Drug-Delivery Nanoplatforms for Antiinflammatory, Antibacterial, and Anticancer Applications: A Review

Zhang

Liu

et al. 2023

ACS Appl. Nano Mater.

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Carbon dots (CDs), as rapidly developing nanomaterials, give new prospects for the treatment of various diseases. Their great biocompatibility and wide specific surface area make CDs excellent drug-delivery vehicles because they improve cellular uptake and absorption and allow for medications to bind more easily. CDs offer enormous potential as delivery systems for antiinflammatory medications. The activities of antiinflammatory drugs delivered by CDs are higher than those of free drugs. They also have controlled release, thus enhancing the cumulative effect at the inflammation site and improving pharmacokinetics. Compared with free small-molecule antibacterial medicines, CD-based drugdelivery systems have higher antibacterial efficacies, better targeting, increased cellular uptake and internalization efficiency, and decreased systemic side effects. The benefits of using CDs as anticancer drug carriers include high drug loading, increased targeting, lower drug dosage, regulated drug release, and synergistic photothermal therapy, which offers a novel approach to the diagnosis and treatment of cancer in clinical settings. However, it is important to consider the biosafety, toxicity, and impact of CDs on the immune system of an organism before using them as drug-delivery vehicles for clinical diagnosis and therapy. This review discusses the use of CDs in the delivery of antiinflammatory, antibacterial, and anticancer drugs and summarizes the current advantages and challenges of using CDs for drug delivery.

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Section: Cds In the Delivery Of Anticancer Drugsmentioning

confidence: 99%

Carbon Dots as Advanced Drug-Delivery Nanoplatforms for Antiinflammatory, Antibacterial, and Anticancer Applications: A Review

Zhang

Liu

et al. 2023

ACS Appl. Nano Mater.

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“…Based on these, ROS-modulating therapies (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy) have been proposed to disrupt either the intracellular or tumor microenvironment (TME) ROS. 10–12 Despite having the advantage of yielding ROS accurately in tumor sites, these therapies are still suffering from the lack of oxygen to generate abundant ROS effectively.…”

Section: Introductionmentioning

confidence: 99%

Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer

Liu¹,

Ye²,

Peng³

et al. 2023

J. Mater. Chem. B

110

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“…The employment of bifunctional monomers enhances the interaction between the template molecules and the substrate, which is beneficial for specific recognition of target molecules. The crosslinking agent BAC, which contains disulfide bonds in the imprinted polymers, is reduced when exposed to the high concentrations of glutathione (GSH) in tumor cells, , resulting in the preliminary degradation of the imprinting layer and exposure of the internal ZIF-8/DOX-HA. However, hyaluronidase (HAase) in the tumor microenvironment decomposes the HA chain .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

Song

Shuang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Improving the drug loading and delivery efficiency of biodegradable nanomaterials used for targeting prostate cancer (PCa) remains a challenging task. To accomplish this task, herein, a new surface molecularly imprinted polymer (ZIF-8/DOX-HA@MIP) was designed and constructed with a hyaluronic acid (HA)-modified zeolitic imidazolate framework-8 (ZIF-8) metal–organic framework loaded with doxorubicin (DOX) as a substrate and a responsive molecularly imprinted polymer film as a shell. Owing to the large surface area of ZIF-8, DOX was successfully loaded into the ZIF-8/DOX-HA@MIP with a high drug loading efficiency (more than 88%). In vitro cell experiments have shown that the strengthened targeting ability of ZIF-8/DOX-HA@MIP to PCa cells was realized through the synergistic effect of HA and the molecularly imprinted membrane. Under the condition of simulated tumor microenvironment solution, Zn species were released and the particle size of ZIF-8/DOX-HA@MIP decreased gradually by the synergistic effect of hyaluronidase, pH, and glutathione, showing excellent biodegradability. In vivo antitumor research indicated the excellent antitumor activity and biocompatibility of ZIF-8/DOX-HA@MIP. The multifunctional ZIF-8/DOX-HA@MIP constructed herein provides a novel impetus for the development of targeted drug delivery in PCa treatment and a new strategy for treating other tumors.

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Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy

Cited by 58 publications

References 31 publications

Carbon Dots as Advanced Drug-Delivery Nanoplatforms for Antiinflammatory, Antibacterial, and Anticancer Applications: A Review

Carbon Dots as Advanced Drug-Delivery Nanoplatforms for Antiinflammatory, Antibacterial, and Anticancer Applications: A Review

Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

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