Radiotherapy of morphea‐type basal cell carcinoma: results in 127 cases

Caccialanza, M.; Piccinno, R.; Çuka, Ermira; Violetti, Silvia Alberti; Rozza, M

doi:10.1111/jdv.12404

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…Superficial and nodular BCCs are considered low-risk tumors, whereas infiltrative BCCs have a higher risk of progression 14 . The latter is associated with a higher recurrence rate after surgery 15 , lower response to radiotherapy 16 , 17 , and rare but fatal metastatic dissemination 18 , 19 . Classically, nodular and infiltrative BCCs are primarily distinguished by the histological morphology of their respective tumor-stroma interface.…”

Section: Introductionmentioning

confidence: 99%

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

et al. 2022

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Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insight required for efficient therapeutic targeting. Here, combining single-cell and spatial transcriptomics on human basal cell carcinomas, we define the cellular contributors of tumor progression. In the invasive niche, tumor cells exhibit a collective migration phenotype, characterized by the expression of cell-cell junction complexes. In physical proximity, we identify cancer-associated fibroblasts with extracellular matrix-remodeling features. Tumor cells strongly express the cytokine Activin A, and increased Activin A-induced gene signature is found in adjacent cancer-associated fibroblast subpopulations. Altogether, our data identify the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche. They also demonstrate the power of integrated spatial and single-cell multi-omics to decipher cancer-specific invasive properties and develop targeted therapies.

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Section: Introductionmentioning

confidence: 99%

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

et al. 2022

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“…However, despite this molecular homogeneity, BCC can display very different morphological aspects and have varying clinical prognoses (Kasper et al, 2012, Telfer et al, 2008). Whereas superficial, micro-nodular and even thick nodular BCC are considered as low-risk tumors, infiltrative BCC are associated with higher tumor recurrence after surgery and lower response to radiotherapy (Breuninger and Dietz, 1991, Caccialanza et al, 2014, Piccinno et al, 2017). Consequently, a better understanding of the functional determinants of nodular and infiltrative phenotypes is of high clinical relevance.…”

Section: Introductionmentioning

confidence: 99%

TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma

Kuonen

Surbeck

Sarin

et al. 2018

Journal of Investigative Dermatology

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Basal cell carcinoma (BCC) is the most frequent human cancer and is becoming an important health problem in an aging population. Based on their clinical and histological characteristics, thick BCC are typically divided into low-risk nodular and high-risk infiltrative subtypes, although the underlying mechanisms are poorly understood. We have identified molecular mechanisms that explain the aggressiveness of high-risk infiltrative BCC, with a potential direct clinical impact. In this study, we first show that fibroblasts, transforming growth factor-β, and fibronectin are found preferentially in infiltrative human BCC. This allowed us to develop in vivo models for the study of infiltrative BCC, which in turn let us confirm the role of transforming growth factor-β in inducing peritumoral fibronectin deposition and tumor infiltration. We then show that fibronectin promotes adhesion and migration of BCC cell lines through integrin α5β1-mediated phosphorylation of focal adhesion kinase. Fittingly, both inhibition of integrin α5β1 and phospho-focal adhesion kinase prevent fibronectin-induced migration of BCC cells in vitro as well as BCC infiltration in vivo. Altogether, our results open important insights into the pathogenesis of aggressive infiltrative BCC and identify integrin α5β1 or focal adhesion kinase inhibition as promising strategies for the treatment of advanced BCC.

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“…In such instances, radiotherapy becomes an alternative approach for the treatment of invasive or inoperable BCCs, with 5 year tumor control rates of 89–100% (87–89). Also, radiotherapy plays an important role in the therapeutic strategy of recurrent BCC (90, 91) or morphea-type basal cell carcinoma (MBCC), which is a rare form of BCC with lower response to treatment than other histologic types (92). …”

Section: Introductionmentioning

confidence: 99%

Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis

Athar

2016

Radiation Research

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This commentary summarizes studies showing risk of basal cell carcinoma (BCC) development in relationship to environmental, occupational and therapeutic exposure to ionizing radiation (IR). BCC, the most common type of human cancer, is driven by the aberrant activation of hedgehog (Hh) signaling. Ptch, a tumor suppressor gene of Hh signaling pathway, and Smoothened play a key role in the development of radiation-induced BCCs in animal models. Epidemiological studies provide evidence that humans exposed to radiation as observed among the long-term, large scale cohorts of atomic bomb survivors, bone marrow transplant recipients, patients with tinea capitis and radiologic workers enhances risk of BCCs. Overall, this risk is higher in Caucasians than other races. People who were exposed early in life develop more BCCs. The enhanced IR correlation with BCC and not other common cutaneous malignancies is intriguing. The mechanism underlying these observations remains undefined. Understanding interactions between radiation-induced signaling pathways and those which drive BCC development may be important in unraveling the mechanism associated with this enhanced risk. Recent studies showed that Vismodegib, a Smoothened inhibitor, is effective in treating radiation-induced BCCs in humans, suggesting that common strategies are required for the intervention of BCCs development irrespective of their etiology.

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Radiotherapy of morphea‐type basal cell carcinoma: results in 127 cases

Cited by 10 publications

References 19 publications

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma

Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis

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