Radiotherapy of squamous cell carcinoma of the nasal vestibule

Radiotherapy for Squamous Cell Carcinoma of the Nasal Vestibule

“…Cosmetic results were poor in 6 patients and good in 2 patients treated with surgery and RT. A neck failure rate of 13% was reported by Langendijk et al, 5 with the majority seen in patients with local recurrence. Salvage attempts lead to an ultimate 5-year regional control rate of 97%.…”

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

“…In historic series on cohorts treating nasal vestibule tumors with conventional RT or brachytherapy, local control and overall survival rates range from 67% to 92% and 50% to 90%, respectively [2,4,6,14]. The largest series of the DAHANCA study group including 174 patients with nasal vestibule cancer reports a local control rate and an overall survival rate of 67% and 50% at 5 years, respectively [14] (Table 3).…”

“…In the latter series RT was delivered in opposed lateral fields (KV or MV) or with an anterior electron field +/-brachytherapy boost. Doses range from 54 Gy in 3 Gy single doses to 62-69 Gy in 2 Gy or 2.5 Gy doses [2,4,14]. Langendijk et al observed rhinorrhoe in 45%, nasal dryness in 39% and epistaxis in 15% of the patients as late toxicity (4).…”

“…Larger studies including nasal tumors executively are mostly not applying chemotherapy [2,4,6,14]. IMRT studies dealing with a heterogeneous patient collective including paranasal sinus cancers were applying systemic therapy in 0 to and 17% [7][8][9][10][11]15].…”

“…Surgical removal often implies complex reconstruction which may end in disfiguring results and consecutively essential impairment of quality of life. Radiation therapy (RT) can be carried out as external beam or brachytherapy, with good local control rates of 67-92% after 5 years [2][3][4][5][6].…”