Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from <i>Penicillium raistrickii</i> IMB17-034

Li, Jiao; Hu, Yuanyuan; Hao, Xiuhong; Tan, Jiali; Li, Fang; Qiao, Xinran; Chen, Shuzhen; Xiao, Chunling; Chen, Minghua; Peng, Zong–Gen; Gan, Maoluo

doi:10.1021/acs.jnatprod.9b00259

Cited by 62 publications

(52 citation statements)

References 26 publications

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“…Extrolites : Atrovenetins, chrysogine, griseofulvins, penicillic acid, peniciketals, peniciraistrins, pestafolide and desmethylcandidusins are produced by ser. Raistrickiorum species ( Belofsky et al., 1998 , Ma et al., 2012 , Ma et al., 2017b , Liu et al., 2014a , Liu et al., 2018a , Li et al., 2019b ).…”

Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

402

458

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The Eurotiales is a relatively large order of Ascomycetes with members frequently having positive and negative impact on human activities. Species within this order gain attention from various research fields such as food, indoor and medical mycology and biotechnology. In this article we give an overview of families and genera present in the Eurotiales and introduce an updated subgeneric, sectional and series classification for Aspergillus and Penicillium . Finally, a comprehensive list of accepted species in the Eurotiales is given. The classification of the Eurotiales at family and genus level is traditionally based on phenotypic characters, and this classification has since been challenged using sequence-based approaches. Here, we re-evaluated the relationships between families and genera of the Eurotiales using a nine-gene sequence dataset. Based on this analysis, the new family Penicillaginaceae is introduced and four known families are accepted: Aspergillaceae , Elaphomycetaceae , Thermoascaceae and Trichocomaceae . The Eurotiales includes 28 genera: 15 genera are accommodated in the Aspergillaceae ( Aspergillago , Aspergillus , Evansstolkia , Hamigera , Leiothecium , Monascus , Penicilliopsis , Penicillium , Phialomyces , Pseudohamigera , Pseudopenicillium , Sclerocleista , Warcupiella , Xerochrysium and Xeromyces ), eight in the Trichocomaceae ( Acidotalaromyces , Ascospirella , Dendrosphaera , Rasamsonia , Sagenomella , Talaromyces , Thermomyces , Trichocoma ), two in the Thermoascaceae ( Paecilomyces , Thermoascus ) and one in the Penicillaginaceae ( Penicillago ). The classification of the Elaphomycetaceae was not part of this study, but according to literature two genera are present in this family ( Elaphomyces and Pseudotulostoma ). The use of an infrageneric classification system has a long tradition in Aspergillus and Penicillium . Most recent taxonomic studies focused on the sectional l...

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Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

402

458

View full text Add to dashboard Cite

show abstract

“…After incubation at 37 °C for 48 h, 10 μL of CCK-8 reagent was added to the cells and they were incubated for another 4 h. Then, the absorbance of each well was recorded at 450 nm. A cytotoxicity assay for Huh7.5 cells was carried out using the MTT method as described previously [5]. The 50% cytotoxicity concentration (CC 50 ) was calculated by Origin 8.0 software.…”

Section: Methodsmentioning

confidence: 99%

“…The antibacterial activities against H. pylori , S. aureus , B. subtilis , P. aeruginosa, and K. pneumonia were assayed by examining the MIC using the broth micro-dilution method as previously described [5,35].…”

Section: Methodsmentioning

confidence: 99%

“…Marine fungi are prolific sources of new structurally diverse compounds, and have yielded more than 1000 new metabolites, many of them displaying interesting biological activities, such as antibacterial, antifungal, antiviral, cytotoxic, and antiprotozoal properties [3,4]. During our ongoing program screening for new bioactive natural products from marine-derived microorganisms [5,6,7,8,9], the extracts from the solid cultures of the marine-derived strain Penicillium sp. IMB17-046 were shown to possess inhibitory activity against HIV-1 replication and antibacterial activities against Gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

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Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

Wang

Hao

et al. 2019

Molecules

Self Cite

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A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC50 values ranging from 0.5 to 7.7 μM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL.

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“…Raistrickindole A ( 7 ) and raistrickin ( 8 ) (Li et al 2019a ) were isolated from the marine-derived fungus Penicillium raistrickii . Both 7 and 8 showed anti-HCV activity in vitro with EC 50 values of 5.7 and 7.0 µM, respectively (as compared to 0.05 µM of the positive control VX-950).…”

Section: Marine Microbial-derived Antiviral Compoundsmentioning

confidence: 99%

Recent progresses in marine microbial-derived antiviral natural products

Teng

Wei

et al. 2020

Arch. Pharm. Res.

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Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034

Cited by 62 publications

References 26 publications

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

Recent progresses in marine microbial-derived antiviral natural products

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