Ralstonia pickettii: a persistent Gram-negative nosocomial infectious organism

Ryan, Michael P.; Pembroke, J. Tony; Adley, Catherine C.

doi:10.1016/j.jhin.2005.08.015

Cited by 165 publications

(161 citation statements)

References 57 publications

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“…While other nonfermenting Gram-negative bacilli, including P. aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia, and Burkholderia cepacia complex, have been recognized as common causes of respiratory infection, the role of Ralstonia species is less well understood. Some Ralstonia species have, however, previously been recovered from a range of infection contexts (27), including the CF airway, most commonly from the species R. mannitolilytica, R. pickettii, and R. respiraculi (23). Here, the relative abundance of Ralstonia species was significantly higher in BAL fluid samples than in sputum samples (P ϭ 0.01, one-way analysis of variance [ANOVA]).…”

Section: Resultsmentioning

confidence: 78%

Complexity, Temporal Stability, and Clinical Correlates of Airway Bacterial Community Composition in Primary Ciliary Dyskinesia

et al. 2013

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g Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormalities in ciliary function, leading to compromised airway clearance and chronic bacterial infection of the upper and lower airways. The compositions of these infections and the relationships between their characteristics and disease presentation are poorly defined. We describe here the first systematic culture-independent evaluation of lower airway bacteriology in PCD. Thirty-three airway samples (26 from sputum, 7 from bronchoalveolar lavage [BAL] fluid) were collected from 24 PCD patients aged 4 to 73 years. 16S rRNA quantitative PCR and pyrosequencing were used to determine the bacterial loads and community compositions of the samples. Bacterial loads, which ranged from 1.3 ؋ 10 4 to 5.2 ؋ 10 9 CFU/ml, were positively correlated with age (P ‫؍‬ 0.002) but not lung function. An analysis of ϳ7,000 16S rRNA sequences per sample identified bacterial species belonging to 128 genera. The concurrently collected paired samples showed high bacterial community similarity. The mean relative abundance of the dominant genera was 64.5% (standard deviation [SD], 24.5), including taxa reported through standard diagnostic microbiology (members of the genera Pseudomonas, Haemophilus, and Streptococcus) and those requiring specific ex vivo growth conditions (members of the genera Prevotella and Porphyromonas). The significant correlations observed included a positive relationship between Pseudomonas aeruginosa relative abundance and age and a negative relationship between P. aeruginosa relative abundance and lung function. Members of the genus Ralstonia were also found to contribute substantially to the bacterial communities in a number of patients. Follow-up samples from a subset of patients revealed high levels of bacterial community temporal stability. The detailed microbiological characterization presented here provides a basis for the reassessment of the clinical management of PCD airway infections.

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Section: Resultsmentioning

confidence: 78%

Complexity, Temporal Stability, and Clinical Correlates of Airway Bacterial Community Composition in Primary Ciliary Dyskinesia

et al. 2013

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“…sepsis contaminating injection solutions and aqueous chlorhexidine solutions. 19 These bacteria were also documented to be related to infection in cystic fibrosis patients. 19 R. paucula and R. gilardii have only been isolated from human clinical samples including cerebrospinal fluid, bone marrow, wounds, and the respiratory tract.…”

Section: (10%)mentioning

confidence: 99%

“…19 These bacteria were also documented to be related to infection in cystic fibrosis patients. 19 R. paucula and R. gilardii have only been isolated from human clinical samples including cerebrospinal fluid, bone marrow, wounds, and the respiratory tract. 21 Previous studies stated that the majority of the Ralstonia isolates showed susceptibility to most of the tested antibiotics.…”

Section: (10%)mentioning

confidence: 99%

The microbial profiles of dental unit waterlines in a dental school clinic

Alkhabuli¹,

Belkadi²,

Tattan³

2017

EDUJ

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“…Therefore, while it is very rare for a healthy person to develop an infection caused by these bacteria, those with an immune deficiency or reduced resistance may develop respiratory infections or blood poisoning due to these organisms Woo et al, 2002;Van der beek et al, 2005 . It has also been reported that these bacteria function as pathogens of healthcare-assoc iated infections Ryan et al, 2006 . Furthermore, due to their ability to pass through membrane filters, cases of infection spread by the consumption of purified water c o n t a m i n a t e d w i t h t h e s e b a c t e r i a h a v e b e e n documented Kendirli et al, 2004 .…”

Section: Proposed Using a C E T I C A C I D O R H Y D R O G E N P E Rmentioning

confidence: 99%