2016
DOI: 10.1039/c5an01786f
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Raman technologies in cancer diagnostics

Abstract: Despite significant effort, cancer still remains a leading cause of death worldwide. In order to reduce its burden, the development and improvement of noninvasive strategies for early detection and diagnosis of cancer are urgently needed. Raman spectroscopy, an optical technique that relies on inelastic light scattering arising from molecular vibrations, is one such strategy, as it can noninvasively probe cancerous markers using only endogenous contrast. In this review, spontaneous, coherent and surface enhanc… Show more

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Cited by 157 publications
(118 citation statements)
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“…The unsaturated‐to‐saturated lipids ratio was obtained by calculating the intensity ratio of (1303 cm −1 /1267 cm −1 )/(1654 cm −1 /1445 cm −1 ). The ratios of Raman intensities at 854 cm −1 to 1124 cm −1 , 814 cm −1 to 722 cm −1 , and 481 cm −1 to 701 cm −1 were respectively used to measure the ratios of protein‐to‐lipid, RNA‐to‐DNA, and glycogen‐to‐cholesterol .…”
Section: Methodsmentioning
confidence: 99%
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“…The unsaturated‐to‐saturated lipids ratio was obtained by calculating the intensity ratio of (1303 cm −1 /1267 cm −1 )/(1654 cm −1 /1445 cm −1 ). The ratios of Raman intensities at 854 cm −1 to 1124 cm −1 , 814 cm −1 to 722 cm −1 , and 481 cm −1 to 701 cm −1 were respectively used to measure the ratios of protein‐to‐lipid, RNA‐to‐DNA, and glycogen‐to‐cholesterol .…”
Section: Methodsmentioning
confidence: 99%
“…In combination with chemometric methods, such as principal component analysis plus linear discriminant analysis (PCA‐LDA), FTIR and Raman spectroscopic analyses have recently shown great promise as a means to facilitate biomarker discovery, sample clustering and classification from spectral datasets . In particular, both FTIR and Raman spectroscopies have been successfully applied in the field of biological and clinical researches, such as environmental toxicology, epigenetics, pathology, laboratory diagnosis and cytology .…”
Section: Introductionmentioning
confidence: 99%
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“…FBE provides microscopic images using fluorescent dyes at the subcellular level although its use is limited to only one fluorescent dye at a time, which has limited the identification of potential multiple targets of a cancer 8 . Another technique, Raman spectroscopy, has also been introduced to discover the molecular characteristics of a cancer by distinguishing the inherent vibrational fingerprints of the cancer cells 9, 10 . Multiplex molecular imaging has been performed by utilizing the nanotags of surface-enhanced Raman scattering (SERS) with high sensitivity 1114 , while its clinical applicability is under evaluation 5, 15 .…”
Section: Introductionmentioning
confidence: 99%
“…As the Raman fingerprint contains rich biological information, variations due to disease or inflammatory processes can be readily observed in the spectral profile [10]. Applications for Raman spectroscopy are rapidly growing, as a tool for disease diagnosis, monitoring disease progression post-treatment, and evaluating treatment effectiveness [11,12]. …”
Section: Introductionmentioning
confidence: 99%