Pipes are used as a means of fluid transportation from a reservoir to a destination. In a piping system, flow loss or head loss is always found, both head loss due to pipe size and head loss due to bends, one of which is the knee. The purpose of this study was to determine the effect of knee diameter on flow headloss. The method used is simulation and monogram calculation. Based on the standard ASME B16.9 B16.28 used knees with a diameter of 1, 2, 4 and inch. The experimental results show the same behavior between the simulation and the monogram calculation. The larger the knee diameter, the smaller the head loss. Headloss simulation results for knee diameters 1,2,4 and 6 inches are 0,012 m, 0,0093 m, 0,00063 m and 0,00426 m, respectively. Meanwhile, the headloss calculated by the monogram is 0.006 m, 0.0024 m, 0.0007 m and 0.004 m, respectively. The smallest headloss occurred at 4 inches in diameter indicating that the knee with this diameter is the best knee among the other four knees