Randomised controlled trial of metronidazole to reduce pain after day case haemorrhoidectomy

Carapeti, EA; Kamm, MA; McDonald, P.J.; Phillips, Rks

doi:10.1016/s0016-5085(98)80028-0

Cited by 18 publications

(28 citation statements)

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“…A recent randomized, controlled trial demonstrated significant reductions in postoperative pain in the first week and in the need for additional analgesia. 4 Patients returned to work earlier and reported greater satisfaction in the metronidazole group than the placebo group. However the use of metronidazole in our study did not result in a significant reduction in pain after closed hemorrhoidectomy.…”

Section: Discussionmentioning

confidence: 93%

“…3 In addition they will require medication, which includes laxatives, and effective, nonconstipating analgesics. 4,5 There have been several studies that have attempted to identify approaches to reduce the pain experienced after hemorrhoidectomy. A variety of preoperative and perioperative regimens have shown mixed benefit.…”

mentioning

confidence: 99%

“…A variety of preoperative and perioperative regimens have shown mixed benefit. [4][5][6][7][8][9][10][11][12] The choice of surgical technique is a subject of great debate. In the United Kingdom, open hemorrhoidectomy is performed most often, in contrast to the United States where closed hemorrhoidectomy is more popular.…”

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confidence: 99%

“…16 Metronidazole has been shown to reduce postoperative pain on days 5, 6, and 7 after open (MilliganMorgan) hemorrhoidectomy. 4 This is thought to be because of the prevention of secondary infection of the wounds. Closed (Ferguson Clinic) hemorrhoidectomy, 17 where the wound edges are sutured, facilitates more rapid healing and may cause less pain than open hemorrhoidectomy.…”

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confidence: 99%

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A Randomized, Double-Blind Trial of the Effect of Metronidazole on Pain After Closed Hemorrhoidectomy

Balfour¹,

Stojkovic²,

Botterill³

et al. 2002

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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A Randomized, Double-Blind Trial of the Effect of Metronidazole on Pain After Closed Hemorrhoidectomy

Balfour¹,

Stojkovic²,

Botterill³

et al. 2002

Diseases of the Colon &Amp; Rectum

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“…However, two recent meta-analyses, comparing the results of hemorrhoidopexy and conventional hemorrhoidectomy with radiofrequency scalpel, did not find any relevant difference in reduction of postoperative pain [18,19]. Metronidazole administration was found to be effective in reducing postoperative pain [20,21]. Local anesthetic infiltration after induction of anesthesia and before the surgical incision contributes to the improvement in pain control after hemorrhoidectomy [22].…”

Section: Complicationsmentioning

confidence: 99%

Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review

Picchio¹,

Greco²,

Filippo

et al. 2014

Indian J Surg

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Surgical therapy guaranties satisfactory results, which are significantly better than those obtained with conservative therapies, especially for Grade III and IV hemorrhoids. In this review, we present and discuss the results of the most diffuse surgical techniques for hemorrhoids. Traditional surgery for hemorrhoids aims to remove the hemorrhoids, with closure (Fergusson's technique) or without closure (Milligan-Morgan procedure) of the ensuing defect. This traditional approach is effective, but causes a significant postoperative pain because of wide external wounds in the innervated perianal skin. Stapled hemorrhoidopexy, proposed by Longo, has gained a vast acceptance because of less postoperative pain and faster return to normal activities. In the recent literature, a significant incidence of recurrence after stapled hemorrhoidopexy was reported, when compared with conventional hemorrhoidectomy. Double stapler hemorrhoidopexy may be an alternative to simple stapled hemorrhoidopexy to reduce the recurrence in advanced hemorrhoidal prolapse. Transanal hemorrhoidal deartertialization was showed to be as effective as stapled hemorrhoidopexy in terms of treatment success, complications, and incidence recurrence. However, further high-quality trials are recommended to assess the efficacy and safety of this technique.

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Clinical Use of Micronized Purified Flavonoid Fraction for Treatment of Symptoms After Hemorrhoidectomy: Results of a Randomized, Controlled, Clinical Trial

Torre¹,

Nicolai²

2004

Diseases of the Colon &Amp; Rectum

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Randomised controlled trial of metronidazole to reduce pain after day case haemorrhoidectomy

Cited by 18 publications

References 0 publications

A Randomized, Double-Blind Trial of the Effect of Metronidazole on Pain After Closed Hemorrhoidectomy

A Randomized, Double-Blind Trial of the Effect of Metronidazole on Pain After Closed Hemorrhoidectomy

Clinical Outcome Following Hemorrhoid Surgery: a Narrative Review

Clinical Use of Micronized Purified Flavonoid Fraction for Treatment of Symptoms After Hemorrhoidectomy: Results of a Randomized, Controlled, Clinical Trial

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