Randomized Controlled Trial of Resistance or Aerobic Exercise in Men Receiving Radiation Therapy for Prostate Cancer

Segal, Roanne; Reid, Robert D.; Courneya, Kerry S.; Sigal, Ronald J.; Kenny, Glen P.; Prud'Homme, Denis G.; Malone, Shawn; Wells, George A.; Scott, Christopher G.; D’Angelo, Monika E. Slovinec

doi:10.1200/jco.2007.15.4963

Cited by 494 publications

(605 citation statements)

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“…Of these, three trials used aerobic exercise (AE) alone { [29];Mello, 2003 #17;Monga, 2007 #7}, while seven trials used AE and resistance exercise (RE) in a combined intervention (CAE) [30][31][32][33][34][35][36]. Four trials compared AE or RE against UC [37][38][39][40].One trial compared two different RE interventions (three or five days per week) against usual care [41]. One trial compared RE alone or together with a low fat vegetable diet against a control group.…”

Section: Search Results and Selection Of Studiesmentioning

confidence: 99%

“…Better effects of AE than UC on muscle strength was reported in five studies; Baumann and colleagues [29] for isometric quadriceps muscle strength (10 % ↓ versus 24 % ↓; p=0.002); Monga and colleagues [43] for time to complete a five repetition sit to stand test (1.3 sec ↓ versus 0.4 sec ↑; p<0.001); Segal and colleagues [40] for 8RM chest press (1.3 kg ↑ versus 2.5 kg ↓; p=0.006);…”

Section: Effect On Muscle Strengthmentioning

confidence: 95%

“…Effect sizes in favour of AE compared to UC were small in two trials by Courneya and colleagues [37] and Segal and colleagues [40] for the outcomes chest press (SMD 0.0; CI -0. Effect sizes were moderate to small both for upper and lower body strength in favour of CAE compared with UC in three trials [30,33,36].…”

Section: Effect On Muscle Strengthmentioning

confidence: 96%

“…In Courneya and colleagues [37], patients in the RE group exercised three days per week for 17 weeks (chest press: 3.3 kg ↑ versus 1.5 kg ↑; p<0.001 and leg press: 8.2 kg ↑ versus 1.4 kg ↑; p=0.001). In a trial by Segal and colleagues [40], patients in the RE group exercised three days a week for 24 weeks (chest press: 10.9 kg ↑ versus 2.5. kg ↓; p<0.001 and leg press 25.6 kg ↑ versus 0.4 kg ↑; p<0.001). In the two trials by Schwartz et al [38,39], better effects for RE than UC was only reported in the most recent study [38] for 1RM overhead press (1.3 kg ↑ versus 0.9 kg ↓; p<0.05), seated row (31.7 kg ↑ versus 1.4 kg ↓; p<0.05) and for leg extension (21.1 kg ↑ versus 1.8 kg ↑; p<0.05).…”

Section: Effect On Muscle Strengthmentioning

confidence: 99%

“…For muscle strength outcomes, moderate to large effects were demonstrated in the trials on breast and prostate cancer patients [30,31,[37][38][39][40] and in trials on HSCT patients [29,32,33,36] but not in patients with advanced stage IV cancer [35], where effects on grip strength were small.…”

Section: Comparing Effects Across Patient Cohortsmentioning

confidence: 99%

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Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene¹,

Helbostad²,

Balstad³

et al. 2013

Critical Reviews in Oncology/Hematology

176

105

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Section: Search Results and Selection Of Studiesmentioning

confidence: 99%

Section: Effect On Muscle Strengthmentioning

confidence: 95%

Section: Effect On Muscle Strengthmentioning

confidence: 96%

Section: Effect On Muscle Strengthmentioning

confidence: 99%

Section: Comparing Effects Across Patient Cohortsmentioning

confidence: 99%

See 3 more Smart Citations

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene¹,

Helbostad²,

Balstad³

et al. 2013

Critical Reviews in Oncology/Hematology

176

105

View full text Add to dashboard Cite

Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active Surveillance

et al. 2021

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IMPORTANCEMen with prostate cancer who are undergoing active surveillance are at an increased risk of cardiovascular death and disease progression. Exercise has been shown to improve cardiorespiratory fitness, physical functioning, body composition, fatigue, and quality of life during and after treatment; however, to date only 1 exercise study has been conducted in this clinical setting.OBJECTIVE To examine the effects of exercise on cardiorespiratory fitness and biochemical progression in men with prostate cancer who were undergoing active surveillance. DESIGN, SETTING, AND PARTICIPANTSThe Exercise During Active Surveillance for Prostate Cancer (ERASE) trial was a single-center, 2-group, phase 2 randomized clinical trial conducted at the

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Neoadjuvant Exercise Therapy in Prostate Cancer

Jones,

Moskowitz,

Lee

et al. 2024

JAMA Oncol

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ImportanceObservational data have shown that postdiagnosis exercise is associated with reduced risk of prostate cancer death. The feasibility and tumor biological activity of exercise therapy is not known.ObjectiveTo identify recommended phase 2 dose of exercise therapy for patients with prostate cancer.Design, Setting, and ParticipantsThis single-center, phase 1a dose-finding trial was conducted at a tertiary cancer center using a patientcentric, decentralized platform and included 53 inactive men with treatment-naive localized prostate cancer scheduled to undergo surgical resection between June 2019 and January 2023. Data were analyzed in June 2024.InterventionSix escalated exercise therapy dose levels ranging from 90 to 450 minutes per week of individualized, moderate-intensity treadmill walking, allocated using adaptive continual reassessment. All exercise therapy sessions were conducted remotely with real-time monitoring.Main Outcomes and MeasuresFeasibility was evaluated by relative exercise dose intensity (REDI). A dose level was considered feasible if 70% or more of patients achieved an REDI of 75% or greater. Activity end points were changes in tumor cell proliferation (Ki67) and plasma prostate-specific antigen levels between pretreatment and postintervention. Safety and changes in patient physiology were also assessed.ResultsA total of 53 men were enrolled (median [IQR] age, 61 [56-66] years). All dose levels were feasible (≥75% REDI). The mean (95% CI) changes in Ki67 were 5.0% (–4.3% to 14.0%) for 90 minutes per week, 2.4% (–1.3% to 6.2%) for 150 minutes per week, –1.3% (–5.8% to 3.3%) for 225 minutes per week, –0.2% (–4.0% to 3.7%) for 300 minutes per week, –2.6% (–9.2% to 4.1%) for 375 minutes per week, and 2.2% (−0.8% to 5.1%) for 450 minutes per week. Changes in prostate-specific antigen levels were 1.0 ng/mL (–1.8 to 3.8) for 90 minutes per week, 0.2 ng/mL (–1.1 to 1.5) for 150 minutes per week, –0.5 ng/mL (–1.2 to 0.3) for 225 minutes per week, –0.2 (–1.7 to 1.3) for 300 minutes per week, –0.7 ng/mL (–1.7 to 0.4) for 375 minutes per week, and –0.9 ng/mL (–2.4 to 0.7) for 450 minutes per week. No serious adverse events were observed. Overall, 225 minutes per week (approximately 5 minutes per treatment at 5 times weekly) was selected as the recommended phase 2 dose.Conclusions and RelevanceThe results of this nonrandomized clinical trial suggest that neoadjuvant exercise therapy is feasible and safe with promising activity in localized prostate cancer.Trial RegistrationClinicalTrials.gov Identifier: NCT03813615

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Randomized Controlled Trial of Resistance or Aerobic Exercise in Men Receiving Radiation Therapy for Prostate Cancer

Abstract: In the short term, both resistance and aerobic exercise mitigated fatigue in men with PCa receiving radiotherapy. Resistance exercise generated longer-term improvements and additional benefits for QOL, strength, triglycerides, and body fat.

Cited by 494 publications

References 21 publications

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active Surveillance

Neoadjuvant Exercise Therapy in Prostate Cancer

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